Rafael Lira

🇧🇷 - 🇩🇪 - 🇳🇱
Biophysicist and music enthusiast

[Rafael Lira @BiophysLira]

@EmbaixadaEUA @grok, isso nao eh interferencia na politica externa?

[Rafael Lira @BiophysLira]

By following GUV growth and bud size in real-time, it is possible to determine the changes in reduced volume (v) and spontaneous curvature (m) and locate the growing vesicles in the shape diagram, with flip flop resulting in a milder increase in m for a given v.

[Rafael Lira @BiophysLira]

The reconstitution of growth and division in synthetic cells faces many challenges. Here, we show one of the most efficient growth system ever described, followed by division, with lipid flip flop as a key regulator of membrane shape

https://t.co/xVuCn9NlvG

[Rafael Lira @BiophysLira]

The addition of CerC6, a molecule that quickly undergoes flip flop, relaxes curvature stresses and lead to the generation of much wider buds

[Rafael Lira @BiophysLira]

The work was done at @tudelft under the excellent supervision of @cees_dekker

[Rafael Lira @BiophysLira]

Fusion of small liposomes to GUV model membranes result in a substantial increase in GUV area. Growth is, nonetheless, accompanied by budding due to curvature effects

[Rafael Lira @BiophysLira]

The buds do not share aqueous connectivity with the main GUV membrane. Photobleaching of an water-soluble probe in the GUV lumen does not result in exchange with the bud content

[Rafael Lira @BiophysLira]

Fusogenic liposomes are an excellent alternative to internalization-based particles for intracellular delivery of cargos. But they don't come without effects.
Here we show how
https://t.co/ly1X3qGKe1
@univgroningen, @FLIM, @GUVs, @drugdelivery

[Rafael Lira @BiophysLira]

@js_neuro It's possible he/she didn't even realize you needed to be acknowledged. Did you try to talk to them? Something similar once happened to me during the proofs (my former boss and I had a great relationship) and I joined the final version of the paper

[Rafael Lira @BiophysLira]

@avioesemusicas High Carbon Footprint

[Rafael Lira @BiophysLira]

@antoniotabet O q mata é o sotaque

[Rafael Lira @BiophysLira]

@PablZambrano @J_A_C_S @BoekhovenLab Looks really cool! Definitely on the list of papers to read

[Rafael Lira @BiophysLira]

https://t.co/tprXYoJb67
@schmidtpolylab @univgroningen @alex_pski @UofGlasgow

[Rafael Lira @BiophysLira]

Polymer droplets exhibit a set of material properties. Small polymers require high concentrations for phase separation. Ultralarge polymers achieve it at much lower concentrations. Are their properties characterized by polymer size, concentration, or both?
Here we address this:

[Rafael Lira @BiophysLira]

@AnnaLinard @neutrophil2024 @CRC_TRR332 This looks amazing

[Rafael Lira @BiophysLira]

@KurisuMinoru Nice, thanks. In my list of papers to read

[Rafael Lira @BiophysLira]

@ja_steinkuehler @Kiel_Nano @JPhysChem Hi Jan, super cool and a hell of a team!
I wonder if there's experimental data on this, from you or anything similar that you may be aware of. Congrats

[Rafael Lira @BiophysLira]

@LeventalLab Thanks, Ilya. There will be more stuff coming in this direction - hopefully soon - that may seem not so unfamiliar to you =)

[Rafael Lira @BiophysLira]

@nadlerlab Thank you Andre

[Rafael Lira @BiophysLira]

Liposomal drug-delivery vehicles that fuse with cells and directly and quickly deliver their cargos in the cytosol can be extremely efficient, but this efficiency may come with a price. Here we show how.

https://t.co/pXfd4scc7a