$KNSA seems like a no brainer to me. What is it worth with derisked next gen antibody for RP after phase 2 later this year? Validated MoA, HLE with more convenient dosing will accelerate market penetration. Also wholly owned so 100% of revenues. What are the bear arguments?
@forfourfun4 hmmm 5x seems high to me. with 387 launch, i would put KNSA at $10B EV. conservatively assuming $2.5B peak sales with 50% market penetration
MAPLE-HCM showed that metoprolol as a BB is harmful. In this complementary analysis presented by @dr_pavia#Heartfailure2026#HFA2026 we showed that the lack of benefit was not a dose dependent finding. More in the slides
#CardioTwitter
@ohadhammer Blina not ideal for I&I. Next gen detune CD3 potency to help with CRS and ICANS. TBD as you said, but experience from cancer trials suggests next gen TCEs will improve on safety