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New in JBC press: "Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission."
Learn more:
https://t.co/WrY9brJcIQ
Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. https://t.co/iWp8RERYFu
🧵a thread
Ultimately, our data support a direct Fis1-Drp1 interaction, in which the Fis1 arm may (via a kinetic effect) occlude the binding site. This interaction promotes mitochondrial fission and suggests the yeast and human proteins are more similar than previously thought. (10/10)
New Hill lab publication from @kanolden and @M_Cleland out in @jbiolchem investigating a long-standing question in mitodynamics in which they show that human Fis1 directly interacts with Drp1 to promote mitochondrial fission! https://t.co/WW87xTDn0U
These results suggest reciprocal interactions between the Fis1 arm and conserved surface are important for Drp1 recruitment and mitochondrial fission. (9/10)
Excited to share that my thesis work and the latest from @Blake_Hill_Lab in which we found human Fis1 maintains an evolutionarily conserved, direct interaction with Drp1 is now out on JBC! #mitochondria https://t.co/z4dHWKAbr0
Had such a great week at @StJudeResearch learning about their facilities, programs, and ongoing research as well as sharing some of our lab's own research! #StJudeNGSS