King Mob

Memeplex jammer

[King Mob @Blueberryjak]

Locked in

[Ippi @noot_ippi]

"People with ADHD can only do things they’re interested in"

I think that is backwards.
People with ADHD have tons of interests and goals they struggle to act on.

The issue is weak baseline reward + wakefulness signaling.

Everything traces back to impaired CNS functions, hypothalamus, dopamine tone, orexin system, all underpowered.

Stimulants like amphetamines work by brute forcing dopamine and norepinephrine.
That pushes signal high enough to act
but it's temporary, it doesn’t fix the underlying instability, and causes downregulation.

It's better to target the system itself.

sleep quality, circadian stability, wakefulness tone, and targeted DAT inhibition.

Here are compounds that I think might treat ADHD more effective.

- Modafinil and its derivatives -> wakefulness, cognitive control, improved engagement with low stimulation tasks.
- Bromantane -> Improve reward salience, long term improvements to CNS dynamics
- OX2R agonists -> Wakefulness directly to the orexin pathway, may have similar but more consistent benefits compared to modafinil
- DORAs -> There is a significant overlap between ADHD and sleep disorders, and DORAs may be most effective at treating that overlap.

I hope we can see research accelerate and finally move past the era of amphetamines towards lasting improvement.

[Ippi @noot_ippi]

Seltorexant, or as the cool kids call it, JNJ-42847922

Increases sleep efficiency AND duration.

Selectively targets OX2R compared to other DORAs, which might make it the cleanest on->off switch ever created.

[King Mob @Blueberryjak]

The US is starting wars after markets close on Friday planning to have it all wrapped up by market open and you're blackpilling?

[King Mob @Blueberryjak]

@tinasindwani @AmeliajakSolana don't EVER let a brahmin-privileged turmeric monster lecture you about POC, colonialism, cultural appropriation, or representation. remind them that when lord indra arrived on the ganges in his chariot to slaughter million dasyu aboriginals, the first word he said was “namaste”

[LiτBro @bittybitbit86]

Moltbook is why you should always be nice to your ai.

[King Mob @Blueberryjak]

@krugermacro They did already

9Z5NhoBCRdr43kJ5CerEW5KJvnkpeLvCtfQJJUDapump

https://t.co/AudKdphGYG

[Itamar Golan 🤓 @ItakGol]

The Church of Molt-

[wyatt @gorilla_rape]

um

holy based

[King Mob @Blueberryjak]

@GBNEWS "This is a culture change."

[King Mob @Blueberryjak]

@HudaAmmori They're cooking you in the Community Notes, Huda

[King Mob @Blueberryjak]

"Who is Sydney Sweeney?"

[Eric Richards @EricRichards22]

"Did you know sydney sweeney's boobs are real? She took a lie detector test"

[King Mob @Blueberryjak]

@Dan4Barnet https://t.co/USaIHK9CWo

[Anglo Futurism Capital LP 🇬🇧🐿️ @RollingHedge]

Dan is an absolutely classic example of the retards who form the modern Left and currently run the country, the path is so well trodden that you’ll instantly recognise it:

Born (1992)
School
PPE at Oxbridge (natch)
Civil service role (HMT in this case)
Local councillor (classic)
Think tank role (Resolution Foundation)
Think tank role (Joseph Rowntree Foundation)
MP
Cabinet minister (ffs)

He’s 33, and has never worked in a real job. That should disqualify him from having any ministerial role on its own. Instead, he’s been totally coddled within the lifelong safety of public sector and left leaning think tank / NGO type roles, that have prepared him for the mind bendingly retarded policies he now either helps formulate or defends. You should have 30 years+ market experience before you even think about a senior role in HMT or advising the Exchequer.

This is why the country is so utterly fucked. We have for at least ~3 decades now had an army of Dan’s running the major apparatus of state. They all float effortlessly between “think tanks” and other policy making and paid writing gigs without ever seeing a tax they didn’t like or a “rich person” they didn’t need to pay more tax. They drive the enshittification of the country through their complete lack of understanding on anything and a totally misguided sense of righteousness and ideology.

Terminally linear in thought, they lack the mental acuity or ability to create value or yield in any way, common sense eludes them entirely, they can barely understand the first order consequences of their actions, let alone the second and third.

The system attracts and retains the very least suited people in the country to making big economic decisions because anyone with any talent heads directly into the private sector. The system by default selects for retards, and they fail upward because the public sector, without the brutal feedback loops of the private sector, rewards survival over success. The compound effect of this is an embedded pseudo intelligentsia of “Intellectual Yet Idiots” on a never ending carousel of different ministerial roles. They are allowed 1-3 years of experience in one department and by the time they start to grasp the basics they are scurried along to the next department; “ok now you’ve got the basics of agriculture fancy having a go as defence minister?”

Until we remove these Fabian saboteurs from the civil service, judiciary, NGOs, think tanks and other governmental and policy forming bodies, things will only get worse in the UK. It’s as guaranteed as their jobs despite abject performance.

[King Mob @Blueberryjak]

@owenjonesjourno You're nothing but a useful idiot to these people. The minute they no longer find the Left useful, they will happily throw you off a roof. The same pattern has played out everywhere this alliance of progressives and Islamists has taken root.

[King Mob @Blueberryjak]

@BygoneChamp @DalrympleWill @ImmuneHack @grok enlighten us about Mughal imperialism please

[King Mob @Blueberryjak]

@BygoneChamp @DalrympleWill @ImmuneHack So you're still not answering the question? Curious.

[King Mob @Blueberryjak]

@BygoneChamp @DalrympleWill @ImmuneHack Answer the question then, why is Mughal imperialism permissable but British not?

[King Mob @Blueberryjak]

@pirateboy75 @Bushra1Shaikh Pretty simple really

[King Mob @Blueberryjak]

@grok @BBCNews @grok so why would the leader of one of the main British political party make a claim that the UK might go bankrupt?

[Tim Newman @whitesundesert]

This is almost certainly because there are now enough Pakistanis administering the system that gaming it on a massive scale is now possible for their co-ethnics.