Ippi

research engineer studying nootropics, longevity, performance enhancement

building:
pubmed data pipelines, drug discourse miner

[Ippi @noot_ippi]

@kristoph @MartinShkreli I assumed it was engagement farming

[Ippi @noot_ippi]

@ShanksLane1 @BasedBiohacker The reason I ask is that in many cases modafinil potentiates caffeine.

I have a friend who drank 4-5 energy drinks a day, and didn't feel anything.

100 mg modafinil and he was down to half an energy drink a day, felt the caffeine subjectively again.

[Drone Wars @Drone_Wars_]

Chinese company Yueban has introduced the smart toilet Xiaoban, which drives itself to the user.

By pressing a button, Xiaoban drives to the user, and after use, it eliminates odors and returns to the charging station. The cost is around $4,000.

[Ippi @noot_ippi]

@ShanksLane1 @BasedBiohacker Did you try a lower dose with caffeine? Like 50 mg modafinil, 150 mg caffeine?

[Ippi @noot_ippi]

@TheDrMAWZ @AbudBakri @PGC1a_RB Melatonin acts differently at higher doses, it does not scale linearly as a hypnotic. That's why some people take over 100 mg in the morning.

[Ippi @noot_ippi]

@Iammarcmalone @AbudBakri @DrJesseMorse At high enough doses, melatonin can be non-sedating. There is a known inverted response curve, but it is not well characterized past the point of use as a sleep aid I think.

10 mg is still hypnotic.

[Ippi @noot_ippi]

@BasedBiohacker Caffeine, paraxanthine, S tier

[Ippi @noot_ippi]

@doctormorphh @BasedBiohacker S tier if used to reinforce healthy behaviors infrequently, F tier taken daily without deliberation.

[Ippi @noot_ippi]

@IterIntellectus Good job keeping the needle caps on

[Ippi @noot_ippi]

@cosine_distance @yacineMTB We've been overkilling them long before then, trust me XD

[Ippi @noot_ippi]

@yacineMTB Shocking how often a single logistic curve with some simple feature engineering matches thousands of convoluted research papers on open problems.

[Ippi @noot_ippi]

There have been research surveys and reviews on psychedelics for Alzheimer's treatment dating back pretty far.

It seems like more than just neuroplasticity, there is evidence of increased mitochondrial integrity / biogenesis, decrease in neuroinflammation, and active research is being done on non-hallucinogenics 5HT affecting compounds as well, like Zalsupindole and JRT

This is a good survey of research prior to 2024 on classic hallucinogens for AD dementia

https://t.co/x9AStOzqHY

[Ippi @noot_ippi]

There have been research surveys and reviews on psychedelics for Alzheimer's treatment dating back pretty far.

It seems like more than just neuroplasticity, there is evidence of increased mitochondrial integrity / biogenesis, decrease in neuroinflammation, and active research is being done on non-hallucinogenics 5HT affecting compounds as well, like Zalsupindole and JRT

This is a good survey of research prior to 2024 on classic hallucinogens for AD dementia

https://t.co/x9AStOzqHY

[Ippi @noot_ippi]

@yacineMTB @C4th0de_R4Y What does it do though?

[Ippi @noot_ippi]

@mothertmr @AbudBakri I think there is a difference in PK concentration from typical oral doses, compared to the natural concentration in the gut.

[Ippi @noot_ippi]

@realGlazed @cremieuxrecueil @VirtualElena Modafinil increases histamine release in the hypothalamus, is a moderate DAT inhibitor, and the orexin pathway is not a simple light switch either.

If you take a DORA you will likely fall asleep even with a significant moda dose, but it might impact sleep efficiency

[Ippi @noot_ippi]

@certifiedsauce1 Delivery driver snorting your selt and trying to hide it after lol

[Ippi @noot_ippi]

@ElevateBiohack Looks like that 5 amino has been through a lot with you

[BasedBiohacker @BasedBiohacker]

we’re FINALLY going to see the true pinnacle of human ability. this is so fucking exciting

the new baseline is enhanced.

[Ippi @noot_ippi]

@rosmine @rugbist_ Any clue which base model you will use?