Akseli Bonsdorff

MD PhD, Helsinki University Hospital.

[Akseli Bonsdorff @BonsdorffA]

❗️DISPAIR + D-FRS, a thread❗️

1/7

2284 patients undergoing left pancreatectomy at 9 different high-volume centers 🏥

497 developed POPF. How well did the D-FRS and the DISPAIR models predict POPF?

D-FRS: AUC = 0.62
DISPAIR: AUC = 0.62

Calibration⬇️

https://t.co/0L4iitbnQY

[Ville Sallinen @villesallinen]

At European Surgical Association (ESA) meeting in Rome, @BonsdorffA presenting our work, GALL-PAL score for predicting pain alleviation after cholecystectomy for uncomplicated cholecystitis. Hope to have this fully out soon!

[Journal of the American College of Surgeons (JACS) @acsJACS]

Compared with stapler closure, hand-sewn closure is associated with worse short-term outcomes, including increased postoperative pancreatic fistula incidence.

📑:https://t.co/qPDYcOxMlj

[Ville Sallinen @villesallinen]

I just received the news that I have been awarded 1.25milEUR grant for the @SigridJuselius professorship! Deeply grateful for all the support from so many during my path! I need to sit down for a while…

[Ville Sallinen @villesallinen]

New study from the DISPAIR consortium @BjsOpen!

Refined classification of postoperative pancreatic fistula after left pancreatectomy based on cumulative morbidity.

Open Access: https://t.co/WrnHwaFrhb

[Ville Sallinen @villesallinen]

Great and inspiring talk by @sparrelid from @HpbKarolinska at Finnish Surgical Society’s Operative Days in Helsinki - Clear benefit of fellowships both for the fellow and the host - win-win! Congrats @KarolinskaUnsju for the huge work!

[Ville Sallinen @villesallinen]

All good things come to an end! Hugely successful #NordicHPB meeting wrapped up!

Spectacular presentations on minimally & maximally invasive HPB, endoscopic methods, oncology, diagnostics and more!

Grateful to all presenters and participants for discussion!

Some highlights👇🧵

[Ville Sallinen @villesallinen]

Assessment of D-FRS on external cohort in San Raffaele, Milan, Italy

AUC 0.49, discrimination and calibration poor.

👉 Shows nicely why external validation is so important!

Would love to see DISPAIR-FRS to be further validated externally!

https://t.co/tHshttMZ0O @spartelli

[Ville Sallinen @villesallinen]

Another 💎 from DISPAIR consortium @SurgJournal: Does neoadjuvant therapy reduce complications after left pancreatectomy?

9 high-volume centers, propensity score matched

Pancreatic fistula: neoadjuvant 20% vs 24%, p=0.7

No diff in other complications.

https://t.co/1EV9bOZ9vB

[Ville Sallinen @villesallinen]

From the DISPAIR consortium group presented by @BonsdorffA at @EAHPBA 2025 Dublin.

Extremely high morbidity heterogeneity within grade B pancreatic fistula (from ab to invasive treatment).

Should we update the postop pancreatic fistula classification?

Here’s a proposal (A-B-C)

[Giovanni Marchegiani @Gio_Marchegiani]

🔵 Pancreas2000 is the young talent group of the @EurPancClub and is aimed at shaping the nextgen of pancreas experts

🙏 I feel very privileged to coordinate this program, our future is in good hands! 💙

[Ville Sallinen @villesallinen]

Relationship between resection rate and survival in pancreatic cancer *at population-level* by @elockie18&al @BjsOpen

👉The more you resect the better survival for the whole population

👉Efforts to increase the resection rate

Commentary by @chiaro_del&al

Links👇

[Akseli Bonsdorff @BonsdorffA]

7/7

This was a huge team effort and I want to extend my heartfelt thanks to everyone from our 30 person collaboration participating! Special thanks of course to @villesallinen for guidance and mentorship🤝

@BJSurgery @BJSAcademy @me4_so @hpb_so

[Akseli Bonsdorff @BonsdorffA]

❗️DISPAIR + D-FRS, a thread❗️

1/7

2284 patients undergoing left pancreatectomy at 9 different high-volume centers 🏥

497 developed POPF. How well did the D-FRS and the DISPAIR models predict POPF?

D-FRS: AUC = 0.62
DISPAIR: AUC = 0.62

Calibration⬇️

https://t.co/0L4iitbnQY

[Akseli Bonsdorff @BonsdorffA]

6/7

Final model, the DISPAIR-FRS, can be accessed at https://t.co/d88P7kpzBC.

⚙️AUC = 0.72
⚙️Calibration slope = 0.93
⚙️Calibration intercept = -0.02

The user has an option to ”calibrate” predictions with institutional baseline risk for POPF.

[Ville Sallinen @villesallinen]

Link to article @BJSurgery (open access): https://t.co/Jtz26OMPPs

Link to calculator: https://t.co/kvT4xdjRJw

[Ville Sallinen @villesallinen]

Predicting risk for pancreatic fistula after left pancreatectomy:

2 risk scores were assessed in international cohort of 2284 patients from 🇫🇮🇬🇧🇸🇪🇫🇷🇳🇴🇨🇦🇩🇰

DISPAIR and D-FRS performed poorly

👉 We combined and validated new DISPAIR-FRS score with better performance

Links 👇