Thomas Stoop

MD, PhD candidate HPB Surgery Amsterdam UMC 🇳🇱| Former Research Fellow Karolinska University Hospital 🇸🇪 & University of Colorado 🇺🇸

[Thomas Stoop @TFStoop]

Published in @TheLancet, our review on #PancreaticCancer
📎Epidemiology🌎
📎Pathogenesis🔬
📎Risk factors & surveillance🕵️
📎Diagnostics🩺
📎Treatment💊
📎Future directions🔍
… by @ammar_asrar, @ObaAtsushi, T. Seufferlein, JW Wilmink, @BasGrootKoerkam & @MarcBesselink

[BJS @BJSurgery]

Surgical outcomes from nationwide implementation of the international best practice for locally advanced pancreatic cancer (PREOPANC-4) study
➡️ https://t.co/Of91znqIgn

Nationwide implementation of the international best practice for LAPC was feasible with nearly three times more resections performed than expected, while morbidity and mortality remained well within predefined safety benchmarks

Work by Thomas F Stoop , Leonard W F Seelen , Freek R van ‘t Land , Jacobien C M Scheepens , Mahsoem Ali , Anna C van der Hout , B Marion van der Kolk , Bert A Bonsing , Daan J Lips , Eric R Manusama , François E J A Willemsen , Freek Daams , Geert Kazemier , Gijs A Patijn , Ignace H de Hingh , Jan H Wijsman , Jennifer Schreinemakers , Joris I Erdmann , J Sven D Mieog , Joost M Klaase , Judith A C Rietjens , Koop Bosscha , Lysanne P M Beuk , Maarten W Nijkamp , Marcel den Dulk , Marnix P M Kop , Mike S L Liem , Misha Luyer , Martijn W J Stommel , Olivier R Busch , Sebastiaan Festen , Stefan Bouwense , Tom M Karsten , Tom W van Ravens , Ulff P Neumann , Vincent E de Meijer , Vincent B Nieuwenhuijs , Werner A Draaisma , Wouter Derksen , Thomas L Bollen , Bas Groot Koerkamp , Casper H J van Eijck , I Quintus Molenaar , Christopher L Wolfgang , Marco Del Chiaro , Matthew H G Katz , Thilo Hackert , Johanna W Wilmink , Hjalmar C van Santvoort , Roeland F de Wilde , Marc G Besselink , the Dutch Pancreatic Cancer Group

#SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol @ksoreide #some4hpb #some4tpl @DPCG_official @pancreatitis_nl @PancreasClub #PancreasClub2023 #PancreaticCancer #Pancreatitis #HCC @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe #PancreaticCancer #cholangiocarcinoma #HPBSurgery #GallbladderCancer #Oncology #LiverSurgery

[Thomas Stoop @TFStoop]

Open access 🗞️: https://t.co/jAlBBu2hEq

[Thomas Stoop @TFStoop]

In @BJSurgery, #LAPC surgical outcome #PREOPANC4 implementation of best-practice LAPC care in #DPCG 🇳🇱 with help of 🇩🇪🇺🇸 experts.

📎 154 LAPC resections 🇳🇱
📎~3x ⬆️ resections than expected

🕵️ in-hosp/30d benchmarks✅:
📍44% major morbidity (<50%)
📍0.6% mortality (<=5%)

👇

[BJS Open @BjsOpen]

Neurogenic diarrhoea after superior mesenteric artery divestment or resection for pancreatic adenocarcinoma following preoperative chemotherapy: international multicentre retrospective study
➡️https://t.co/XILytX2HrP

In this international multicentre study including 291 patients with superior mesenteric artery (SMA) divestment/resection during surgery for pancreatic adenocarcinoma after preoperative chemotherapy, postoperative neurogenic diarrhoea occurred in 66% of patients, particularly after > 180° SMA divestment or resection. Although challenging to manage, neurogenic diarrhoea was not associated with impaired survival.

👏👏👏@TFStoop , Chiara Croce , Hiroyuki Ishida , Mahsoem Ali , Ammar A Javed , Asif Halimi , Atsushi Oba , Bas Groot Koerkamp , Carl-Stephan Leonhardt , Cornelius A Thiels , Elena Rangelova , Ernesto Sparrelid , Ira Sotirova , Jennifer L Leiting , Jun Tauchi , Kosuke Kobayashi , Marit Klos , Lysanne P M Beuk , Luana Genova , Manuela Mastronardi , Michael L Kendrick , Nabiha A Mughal , Olivier R Busch , Oskar Franklin , Patrik Larsson , Ulla Klaiber , Richard D Schulick , Rutger T Theijse , Oliver Strobel , Poya Ghorbani , Roeland F de Wilde , Salvador Rodriguez Franco , Toshitaka Sugawara , Johanna W Wilmink , Wells Messersmith , @MarcBesselink , Christopher Wolfgang , Yosuke Inoue , Mark J Truty , @chiaro_del on behalf of the , International Collaboration on Advanced Pancreatic Cancer
#SoMe4Surgery #MedTwitter #SurgEd #Surgery @BJSAcademy @BJSurgery #some4hpb #some4tpl @hpb_so #PancreaticCancer #PancreaticSurgery @YouppiePancreas @German_PancClub @surgery_hps #PancreasClub2023 @PancreasClub @DPCG_official @pancreatitis_nl @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe

[Thomas Stoop @TFStoop]

Full text 🗞️: https://t.co/NFoUzaMDiX

[Thomas Stoop @TFStoop]

In @BjsOpen, study 🇳🇱🇩🇪🇸🇪🇺🇸🇮🇹 on surgery risks in #pancreascancer #LAPC after preop RTx ☢️:

⬆️ major morb after RT (38% vs 24%)
📎especially if arterial resection
📎especially if EBRT

🖇️no significant association of RT with PPH 🩸 (11% vs. 5%)

🚨selection & counselling

[Thomas Stoop @TFStoop]

Full text 🗞️: https://t.co/ll5SuHlK0Y

[Thomas Stoop @TFStoop]

In @BjsOpen, study 🇳🇱🇦🇹🇺🇸🇯🇵🇸🇪 on #neurogenic #diarrhea after #pancreaticcancer surgery with SMA divestment/resection:

📎66% rate, mostly if >180° SMA divestment/resection
🚨large treatment heterogeneity ➡️ 51% normalized
👍 no ⬇️ OS

🔎definition & evidence-based strategies⚠️

[NEJM @NEJM]

Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) https://t.co/y4G27hfORg

#ASCO26 | @ASCO

[Marc Besselink @MarcBesselink]

#HoraEst 🎓 @IngmarFRompen today @UvA_Amsterdam “Extended indications for #pancreatic #surgery (#promotie). Well done Ingmar!!

➡️ https://t.co/PP3AWsqBwk

🎯Amazing thesis including 14 chapters, all published, including 9x(!!) @AnnalsofSurgery. Thanks to all 99 co-authors from 🇩🇪🇺🇸🇳🇱 🇮🇹🇳🇴🇸🇪🇫🇮🇩🇰🇬🇧🇯🇵

✅ Wonderful collaborative PhD team @MarcBesselink @cw_michalski 🇩🇪 @cwolfga2 🇺🇸 @ammar_asrar 🇺🇸 @DPCG_official

Thanks to the excellent committee including @Gio_Marchegiani @TFStoop @i_verpalen @HenrikNien

[Marc Besselink @MarcBesselink]

#PELICAN randomized trial @DPCG_official 🇳🇱 published @JAMANetworkOpen:

❓Can #RFA following induction chemoth improve survival vs chemoth only in 188 pts with nonprogressive but nonoperable locally advanced #pancreaticcancer (#LAPC)?

🔑 No. Moreover QoL ⤵️ 👀

#PREOPANC4 coming up.

▶️ https://t.co/Gjrsnxlap0

[Marc Besselink @MarcBesselink]

#Horaest 🎓 @TFStoop #CumLaude PhD ceremony today 🙌 (best 3% thesis)
“A #paradigm #shift in localized #PancreaticCancer” @DPCG_official, @UvA_Amsterdam

⏩️ https://t.co/jNoVkQwpE6

✅#PREOPANC4 nationwide 🇳🇱 implementation LAPC surgery
✅International, national studies on #neoadjuvant #adjuvant treatment #quality of life and #surgery in #PancreaticCancer
✅543 pages, 19 chapters (incl @TheLancet), 150 co-authors, 20 countries, 286 impact factor points; median 10+.

Thank you @sparrelid🇸🇪 for the excellent discussion!

[CUpancreas @CUpancreas]

Proud to have Dr.Oba in our Division! Dive into the story below.

[Marc Besselink @MarcBesselink]

Bihormonal Artificial Pancreas after #Total #Pancreatectomy?
✅Protocol #PANORAMA trial published @BjsOpen @DPCG_official 🇳🇱 >> results coming up….

⏩️ https://t.co/PjhhEFmcLj

[Thomas Stoop @TFStoop]

@CUpancreas @CUDeptSurg @RichSchulickMD @chiaro_del Thank you @RichSchulickMD. It has been an honor working for you at @CUAnschutz, inspired by your expertise, leadership, and kindness 🙏🏻.

[CUpancreas @CUpancreas]

We extend our sincerest gratitude to Dr. Schulick for his exceptional service as Chair of the @CUDeptSurg, during which he guided significant growth and innovation. His vision and dedication leave an extraordinary impact. #ImproveEveryLife @RichSchulickMD @chiaro_del

[Marc Besselink @MarcBesselink]

#HoraEst today for @annegehrels om #PancreaticCancer with
@DPCG_official 🇳🇱 @UvA_Amsterdam

⏩️ https://t.co/OkVnQkROVT

✅#NAPAN trial: Second-line liposomal irinotecan plus S-1 vs. liposomal irinotecan plus 5-fluorouracil in metastatic pancreatic cancer: the phase I/II randomized trial
✅#PREOPANC5 trial protocol: Neoadjuvant mFOLFIRINOX, pembro, and SBRT for borderl resect pancreatic cancer: multicenter phase 1/2 single-arm trial

Excellent multidisciplinary collaboration Hanneke Wilmink, Hanneke van Laarhoven an in the committe Davide Melisi 🇮🇹

[Marc Besselink @MarcBesselink]

#HoraEst today for @MichielFrancken @amsterdamumc @UvA_Amsterdam

“Interventions for pancreatic diseases”
✅ #POINTER trial costs
✅#PICUS2 cholecystectomy for idiopathic pancreatitis, trial design
✅#PANACOTTA (obot vs open PJ chronic pancreatitis, trial design

Incl committee @DeMadaria 🇪🇸 gracias Enrique🙌

https://t.co/K2G6XSo7hH

[Flavio G Rocha, MD, FACS, FSSO @FlavioRochaMD]

The evidence would support performing diag
laparoscopy prior to #NAT💊 and surgery✂️

22% detection rate of occult metastases on🥢
in upfront resection pts in modern series with
high quality imaging 🖥️ at experienced center

@PanCAN @SocSurgOnc @IHPBA

https://t.co/2FtHbBcSVz

[Syed A. Ahmad @SyedAAhmad5]

Staging laparoscopy to detect occult metastases in localized pancreatic cancer: global survey among nine international societies https://t.co/gt9Z1ZK1z8