The Boulton Lab

Our diverse lab at @TheCrick studies mechanisms of DNA repair at breaks/forks/telomeres in health & disease | Now on 🦋

[The Boulton Lab @BoultonLab]

Similar results are obtained by independent labs @makotothayashi2 in Kyoto University/IFOM and @ZierLab at ICR.

[The Boulton Lab @BoultonLab]

Our latest is out! 🥳We found cGAS engaged w/ ruptured micronuclei can't activate downstream signalling. Our observation challenges current dogma that cGAS binds to self-DNA in micronuclei and triggers innate immune signalling.
Spearheaded by Tohru @Wgctt1 with @Rhona_mill.

[The Boulton Lab @BoultonLab]

Cells retained the ability to activate cGAS-STING in response to dsDNA or modified vaccinia virus infection. We provide evidence that micronuclei formed by genotoxic insults contain histone-bound self-DNA, which is inhibitory to cGAS activation. Link below https://t.co/w3acOgT37q

[The Boulton Lab @BoultonLab]

Long story short… 🧬 Amazing science in Rome, making ends meet, forza telomeres! @TeloEMBO2024

[The Boulton Lab @BoultonLab]

We have great news - our postdocs @MartinaPeritore and @RRJLow have been awarded #MSCA postdoctoral fellowships!! Congratulations 🥳🙌🏾👩🏾‍🔬👨🏾‍🔬 Looking forward to the exciting science to come!

[Fusion Conferences @Fusion_Conf]

@BoultonLab closes day 3 with a fabulous two part Plenary talk on ALT and the EXO1 story!! We hope to announce an exciting collaboration with Simon very soon… watch this space 🧬 #DRRSC24

[The Boulton Lab @BoultonLab]

In summary, we observed human BRCA2 is capable of nucleating RAD51 either directly onto ssDNA or ds-ssDNA junction; or via diffusion-assisted delivery aided by sliding along dsDNA. This work was a great collaborative effort between @BoultonLab, @SCWestLab and others. (10/10)

[The Boulton Lab @BoultonLab]

Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10)
https://t.co/hfn2uWSoOw

[The Boulton Lab @BoultonLab]

BRCA2 is mutated in breast and ovarian cancer. W/ help from Lucas Kuhlen (Xiaodong Zhang lab @ICStructBio) & @roopesh_anand we observed that BRCA2 truncations were impaired for RAD51 nucleation or sliding. C-terminus loss made BRCA2-DNA interaction particularly labile! (9/10)

[Alberto Ciccia @CicciaAlberto]

We have open postdoctoral positions at Columbia University funded by our NIH T32 grant! If you are interested in studying genome or epigenome integrity, come and join us!

[The Boulton Lab @BoultonLab]

Congratulations to Prof Sir Steve Jackson on receiving a knighthood in the King's #BirthdayHonoursList for @SPJacksonGroup's pioneering research on the DNA damage response and its translation into the clinic. Well deserved, Steve! 👨‍🔬🧪🧬🎉🥳

[CRUK Cambridge Institute @CRUK_CI]

Hearty congratulations to Prof Sir Steve Jackson, Senior Group Leader @CRUK_CI, who has received a knighthood in the King's first #BirthdayHonours List for his services to innovation and research 🎉

Read more about his remarkable achievement here⬇️
https://t.co/bUtHs3vPkb

[Science and Innovation at Cancer Research UK @CRUKresearch]

“The vision of Radnet was to bring in a new generation of researchers w/ skillsets that we could apply to study the problem of #radiation, which is a big opportunity for cancer treatment.” Hear more from Simon Boulton, Director @RadNetCRUKCoL: https://t.co/uf9afiyVy7