The West Lab

The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own

[The West Lab @SCWestLab]

We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) https://t.co/XFutf8w6ni. Thread ⬇️⬇️⬇️ (1/8)

[Costa Lab @CostaLabCrick]

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! https://t.co/D13VcIXABT

[ConstantinouLab @ConstantinouL]

We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK

[Fusion Conferences @Fusion_Conf]

📣#RECOMBINATION25 PROGRAMME NOW LIVE!
Exciting news! The first draft of the programme for the 2nd Recombination Mechanisms conference is now available. 🌟

🗓Important Deadlines:
Early Bird & Talk Submission – 28 Nov 2024
Poster Submission & Registration Deadline – 13 Mar 2025

Don’t miss out—check out the programme and get all the details here:
https://t.co/N8HpwJ9tM1

[The West Lab @SCWestLab]

@Jiangchuan_Shen While we observed interaction between the N-terminus of RPA (DBD-F, DBD-A and DBD-B) with RAD52, it is dispensable for the stimulation we observed in the single-stranded DNA annealing assay (Extended Data 11g).

[The West Lab @SCWestLab]

We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) https://t.co/XFutf8w6ni. Thread ⬇️⬇️⬇️ (1/8)

[Eric Chih-Chao Liang @EricCCLiang]

Delighted to share that my manuscript of "Mechanism of single-stranded DNA annealing by RAD52-RPA complex" is now in Nature!

[The West Lab @SCWestLab]

This work was an incredibly collaborative effort between our group (@LukeGreenhough, @ilirjanabajrami @Tuppi1987), the fantastic facilities at the @TheCrick, and funded by @BBSRC and @ERC_Research

[The West Lab @SCWestLab]

Our structural, biochemical and biophysical analyses provide a model by which human RAD52 open-ring cooperates with RPA to facilitate single-stranded DNA annealing repair. Our findings may provide new ways of targeting RAD52 in BRCA2 deficient tumours (7/8)

[The West Lab @SCWestLab]

Looking forward to it!

[Fusion Conferences @Fusion_Conf]

@SCWestLab we're looking forward to your presentation at #DNARepair24 in Malta this October! 🇲🇹 Please RT to let your followers know you'll be speaking & that Early Bird & Talk Submission close on 02 May 2024. Find out more ➡️https://t.co/kDM6YJ9npL

[The West Lab @SCWestLab]

📣@TheCrick has launched The Translation Scholar 🎓 initiative, a new role that combines #AcademicResearch with #Entrepreneurship to bring technologies to market. Congrats to @lola_anaid for being the inaugural holder.🔬💼 We're also hiring! https://t.co/rXNxynEQ0v

[The West Lab @SCWestLab]

Merry Christmas from the West lab 🎄

[The Francis Crick Institute @TheCrick]

Congratulations to Caroline Hill and Xiaodong Zhang on being awarded almost £6 million in @wellcometrust Wellcome Discovery Awards to study DNA repair and organ development in zebrafish and humans 🥳
https://t.co/ULQr7mahBn

[The West Lab @SCWestLab]

Our latest paper uses structural biology, biochemistry & biophysics to reveal the two-step catalytic mechanism of the human nucleotide pool sanitiser DNPH1. This will aid the development of novel inhibitors, which may be of use in breast cancer treatment. https://t.co/ktJJ8Enj9g

[The Francis Crick Institute @TheCrick]

We awarded our annual Translation Prize last night, recognising researchers at the Crick who are applying their research in a real-world setting.

Congratulations to our winner Anaid Benitez, runner-up Andreia Bernardo and all the nominees! 🏆🎉https://t.co/uWeTQsEWYV