Jeffrey Brault, PhD

Associate Professor in the Center for Musculoskeletal Health at the Indiana U School of Medicine. Skeletal muscle energetics and the control of muscle mass.

[Bioenergetics Communications @bioenerg_commun]

Mitochondria are increasingly recognized as actionable targets in disease. These BEC papers look at different approaches, from targeting signaling pathways and mitochondrial metabolites to developing compounds for mitochondrial disease and cancer.
#DrugTargeting
Links👇

[Jeffrey Brault, PhD @BraultMuscleLab]

Thrilled to publish our skeletal muscle-centric study of mitochondrial transacylase deficiency. The NMJ adaptations are surprising. Awesome work by post-doc Catalina Matias and wonderful collaboration with Simon Conway and lab. @IUICMH @IUImpact

https://t.co/mdSjekRxU7.

[The Hornberger Lab @HornbergerLab]

📢Tenure Track Faculty Position: UW-Madison is expanding its research portfolio in aging and is interested in applicants who study the interplay between aging and skeletal muscle biology. 10 days left to apply - please RT and DM if you have questions. https://t.co/u0dWirW6H6

[Jeffrey Brault, PhD @BraultMuscleLab]

2nd Annual Global ADSS1 Scientific & Clinical Conference in Boston, MA was a great success - demonstrating massive progress in understanding this devastating myopathy of purine metabolism. I'm fortunate to be a small part of this dedicated group. #ADSS1

[Marcas Bamman, PhD @MarcasBamman]

Join us!

[Jeffrey Brault, PhD @BraultMuscleLab]

Have you ever wondered whether ATP alone is a good measure of mitochondrial function? It is not! In this review, we address ATP and the energetic state in a mitochondrial metabolic disorder.
@IUICMH @IUImpact

https://t.co/LzSl3Iy15t

[Jeffrey Brault, PhD @BraultMuscleLab]

Happy to be a small part of this impressive study on the integrated stress response and purine metabolism in prostate cancer cells.

[Advanced Prostate Cancer Consensus Conference @APCCC_Lugano]

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

https://t.co/TIM2VmwKqb

This study explores how the integrated stress response (ISR) helps prostate cancer cells survive, particularly those lacking the p53 tumor suppressor. Researchers found that inhibiting the ISR kinase GCN2 in p53-deficient #ProstateCancer cells disrupts amino acid availability, which is crucial for purine nucleotide synthesis. This disruption is deadly to p53-deficient cells because they cannot initiate the protective cell cycle arrest and senescence that p53 typically triggers. In contrast, p53-functional tumors can survive GCN2 inhibition. In mouse models, GCN2 inhibition slowed tumor growth in both types but was especially lethal to p53-deficient tumors, suggesting a potential therapeutic strategy for targeting p53-deficient prostate cancers.

@BraultMuscleLab
@kirkstaschke

Ping
@nataliagandur @yekeduz_emre @bavilima

[Jeffrey Brault, PhD @BraultMuscleLab]

Happy to share our exciting, new mito-myopathy model — KO of Sucla2. Despite similar loss of enzyme activity and increase in protein succinylation across muscles, we show dramatic muscle-specific phenotypic changes between muscles.

https://t.co/M3szVagER5

[Jeffrey Brault, PhD @BraultMuscleLab]

I'm happy to be part of this exciting conference on a devastating but rare neuromuscular disease, ADSSL1 myopathy. Looking forward to learning from these experts.
#ADSSL1
#RareDisease

[Jeffrey Brault, PhD @BraultMuscleLab]

While uric acid is largely thought to be produced in the liver, where do the precursors come from? Muscle!
Excited to share that this major piece of @SpencerGMiller dissertation work was selected for the cover of @JCI_insight
@IUICMH

[JCI insight @JCI_insight]

#Cover: Uric acid formation is driven by crosstalk between skeletal muscle and other cell types: https://t.co/YGGuP290F8

An immunofluorescence #image of C2C12 myotubes displaying myosin heavy chain (orange) and nuclei (blue); Credit: @SpencerGMiller
@BraultMuscleLab @IUMedSchool

[Jeffrey Brault, PhD @BraultMuscleLab]

ADP concentrations generally cannot be measured in vivo, but they can be accurately estimated in muscle! Happy to be a small part of this tour de force to integrate major physiological factors into the calculations of creatine kinase equilibrium.
https://t.co/cgLTrO9Kk3

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

Excited to announce our group's latest preprint led by @IlyaNBoykov + @Mcmontgomery11
https://t.co/6ugOG5Vm1Q

In it we compared OXPHOS expression/function, across various murine tumor types, matched normal tissues and other organs -- all normalized to mito content.

🧵below

[Shenhav Shemer Lab @Shenhav_Lab]

It is with great sadness that we mourn the passing of Prof. Alfred Goldberg, my postdoc mentor and colleague. Fred’s contributions to science were profound and far-reaching, and his passing leaves a void. He was a passionate advocate for science and education. We will miss him.

[Everett Minchew @everettminchew]

No oxygen? No problem 💪

Thrilled to reveal evidence of a mammalian skeletal muscle that functions properly without O₂. A massive effort by the team!

@EspenLab @APS_Function @MYOTWlTTER #myotwitter

https://t.co/SdYYbjNxnO

[Jeffrey Brault, PhD @BraultMuscleLab]

Another great day at the Advances in Skeletal Muscle Biology Conference at University of Florida #MyoTwitter

[Journal of Applied Physiology @japplphysiol]

#ArticlesInPress “Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1” By: Paul S. Hafen, et al.
https://t.co/QWHsIJQmp0
#JAPPL #Fatigue #SexDifferences

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

📢#Mitochondria and #Cancer drug resistance📢

How much energy does it cost to run drug efflux pumps?

This and more are what we set out to answer in our latest work, just published in BBA – Bioenergetics.
https://t.co/OvrHLiwVGw
🧵below 1/

[Jeffrey Brault, PhD @BraultMuscleLab]

Congratulations Dr. Miller @SpencerGMiller on your successful PhD defense!
One of the great pleasures of being an academic professor is the success of your students. I am proud of Spencer and am confident he will continue to achieve great things.

[Jeffrey Brault, PhD @BraultMuscleLab]

We are excited to share our new chromatography method for ATP and associated molecules. This was driven by graduate student Andrew Law.

https://t.co/0SvDrKa2f4