Frederik Simonsen Bro

Postdoctoral researcher in the Clementson group at Department of Chemistry at Lund University

[Frederik Simonsen Bro @BroSimonsen]

My latest first author publication - and first as a co-corresponding author - is out in JACS Au. Check it out!

[Luca Laraia @laraialab]

Check out our new paper in @JACS_Au on the early- and late-stage chemoenzymatic functionalization of steroid-inspired compounds! (1/5)
https://t.co/z9wJ8NMYJZ

[Frederik Simonsen Bro @BroSimonsen]

My latest first-author ChemRxiv preprint - and my first as a co-corresponding author - from my PhD external stay and postdoc work! https://t.co/nLNlLFAtJk Thanks to @laraialab and @hanzyduzit for a fruitful collaboration!

[Frederik Simonsen Bro @BroSimonsen]

Thank you to @ChemicalScience for featuring @laraialab's and my work, “Unifying principles for the design and evaluation of natural product-inspired compound collections” (https://t.co/4pvBsGW5b3), in their 2025 most popular organic synthesis articles collection!

[Frederik Simonsen Bro @BroSimonsen]

From the 1st of October, I will be joining the group of Assistant Professor Sebastian Clementson (@SebbeClement) in the Department Chemistry at Lund University working on the total synthesis of complex terpenoid natural products.

[Frederik Simonsen Bro @BroSimonsen]

My first perspective is out in @ChemicalScience!
@laraialab and I give our thoughts on the synthesis of natural product-inspired compounds. Check it out!

[Luca Laraia @laraialab]

Interested in natural product-inspired compounds? Check out our new perspective in @ChemicalScience: https://t.co/iyWP3Ojx3i

Deciding which synthesis strategy to pursue can be daunting, particularly as new strategies keep emerging! 1/2

[Biomimetics @Biomimetics_abe]

Unifying principles for the design and evaluation of natural product-inspired compound collections | Chem. Sci. https://t.co/uycwUhemVe

[Chemistry News @ChemistryNews]

Unifying principles for the design and evaluation of natural product-inspired compound collections https://t.co/tYgSyobyZh

[Frederik Simonsen Bro @BroSimonsen]

@AMSzpilman Thanks!

[Frederik Simonsen Bro @BroSimonsen]

My first publication as first author is out in ACS Central Science. Check it out!

[Luca Laraia @laraialab]

Great start to 2025 for the lab, as our latest paper on sterol transport protein ligands was just published open access in @ACSCentSci! 1/n https://t.co/XDdLPori6Y

[Frederik Simonsen Bro @BroSimonsen]

@laraialab Thanks, and likewise!

[Frederik Simonsen Bro @BroSimonsen]

I successfully defended my PhD on the 4th of November! Thanks to @laraialab and @hanzyduzit for great supervision and to @Adam_S_Nelson, @ThomasBPoulsen, and @KramerChemistry for nice discussions at the defence!

[Frederik Simonsen Bro @BroSimonsen]

Truly proud of this work! Huge thanks to @laraialab, @Laura_dta, @NienkeJDekker, @HoganBryceRoge1, @tomeveriss, Kaia, @TinoPetersson, and @MariuszKubus for their contribution!

[Luca Laraia @laraialab]

Second pre-print of the week!🥳This time @ChemRxiv we discover a funky 3D spirooxepinoindole core as a privileged scaffold for inhibiting sterol transporters! 1/n https://t.co/bs9kvoYhJ8

[Luca Laraia @laraialab]

NEW pre-print! Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters. Fantastic work by @Laura_dta with support from @HoganBryceRoge1, @NienkeJDekker, Anna and Nicolo! 1/n https://t.co/z0mh8bm3Mr

[Luca Laraia @laraialab]

Big day for the lab as our latest paper is out in Nature Chemical Biology @nchembio on identifying the oxybipins as new OSBP inhibitors, as well as their mechanism of action and therapeutic applications! https://t.co/oP2HIcDiUT 1/n

[Hans Renata @hanzyduzit]

We found a rather promiscuous aKG enzyme that can desaturate or hydroxylate a number of monocyclic/bicyclic substrates and develop its synthetic application. I'm personally quite fond of the desymmetrization-azidation shown below.
https://t.co/DuIFMPVE3l

[Hans Renata @hanzyduzit]

We verified the function of a C–S bond forming P450 in griseoviridin biosynthesis for the first time and developed a short chemoenzymatic synthesis of the natural product: https://t.co/U9AB4S2rnt

[Luca Laraia @laraialab]

Delighted to take part in this @thiemechemistry cheminar! Dial in on May 29th to hear more about our work on natural product-inspired compound synthesis with different applications! https://t.co/S4g8FuzbpG

[Frederik Simonsen Bro @BroSimonsen]

Huge congratulations to my colleague and good friend. Well deserved!

[Joseph Hoock @HoockJoseph]

I'm super happy and proud to share that today I won a prize for Best PhD in Medicinal Chemistry in Denmark. Grateful for my supervisor @laraialab and all collaborators I got to work with along the way. Excited to represent Denmark at the #EFMC-ISMC 2024 in Rome later this year.

[Luca Laraia @laraialab]

New paper in Bioorg Med Chem on degraders of the sterol transport protein Aster-A! We use the pomalidomide core as a fluorescent handle to determine binary binding constants, develop competitive assays, determine cell permeability + degrade Aster-A! 1/n https://t.co/6ZUCs5aKKC