I'm super happy and proud to share that today I won a prize for Best PhD in Medicinal Chemistry in Denmark. Grateful for my supervisor @laraialab and all collaborators I got to work with along the way. Excited to represent Denmark at the #EFMC-ISMC 2024 in Rome later this year.
We were in fact able to show that a designated PROTAC led to specifc concentration dependent stabilisation, while the underlying small molecule KY02111 degraded our target squalene synthase. Enjoy the read!
I'm excited that my project on degraders and stabilisers of SQS is out in Chemical Science as #ChemSciPicks. Gratefull for working with Cecilia, Mesut, @ERADLab, @Laura_dta and ofc @laraialab on this.
๐ขNew #PhDposition! Work with us @ChemistryDtu to develop tools for determining target engagement, selectivity and phenotypic effects of inhibitors of sterol transport proteins. Deadline: 27th July, but applications assessed continuously. Please RT https://t.co/0fbJrxVRah
My first preprint is out now! We targeted squalene synthase, an important enzyme for #cholesterol biosynthesis and identified small molecule degraders and stabilizers. Grateful for guidance by @laraialab ๐ big thanks to Cecilia, @Laura_dta, @ERADLab and Mesut!
New preprint! We discovered degraders and stabilizers of the #cholesterol biosynthesis enzyme squalene synthase, based on the same scaffold! Great work by PhD student @HoockJoseph, with support from Cecilia, @Laura_dta and collaborators Mesut and @ERADLab! https://t.co/zi8vUxpnrg