Joseph Hoock

PhD student @ Laraia lab, DTU Chemistry
Chemical biologist with interest in targeted protein degradation

[Joseph Hoock @HoockJoseph]

@EthanToriki @laraialab Thank you so much Ethan:)

[Joseph Hoock @HoockJoseph]

I'm super happy and proud to share that today I won a prize for Best PhD in Medicinal Chemistry in Denmark. Grateful for my supervisor @laraialab and all collaborators I got to work with along the way. Excited to represent Denmark at the #EFMC-ISMC 2024 in Rome later this year.

[Joseph Hoock @HoockJoseph]

@laraialab Thank you Luca, your great supervision, guidance and believe in me enabled me to do this :)

[Joseph Hoock @HoockJoseph]

@DankovaDaniela @laraialab Thank you Daniela :)

[Joseph Hoock @HoockJoseph]

@NikolasKlink @laraialab Thanks Niko :)

[Joseph Hoock @HoockJoseph]

@BroSimonsen Thanks Frederik :)

[Joseph Hoock @HoockJoseph]

@BroSimonsen Thx Frederik :)

[Joseph Hoock @HoockJoseph]

We were in fact able to show that a designated PROTAC led to specifc concentration dependent stabilisation, while the underlying small molecule KY02111 degraded our target squalene synthase. Enjoy the read!

[Joseph Hoock @HoockJoseph]

I'm excited that my project on degraders and stabilisers of SQS is out in Chemical Science as #ChemSciPicks. Gratefull for working with Cecilia, Mesut, @ERADLab, @Laura_dta and ofc @laraialab on this.

[Luca Laraia @laraialab]

Delighted that our paper on degraders and stabilisers of squalene synthase in @ChemicalScience has been highlighted as #chemscipicks! Fantastic work by @HoockJoseph with great support by Cecilia, Mesut, @ERADLab and @Laura_dta!

[Luca Laraia @laraialab]

📢New #PhDposition! Work with us @ChemistryDtu to develop tools for determining target engagement, selectivity and phenotypic effects of inhibitors of sterol transport proteins. Deadline: 27th July, but applications assessed continuously. Please RT https://t.co/0fbJrxVRah

[Joseph Hoock @HoockJoseph]

My first preprint is out now! We targeted squalene synthase, an important enzyme for #cholesterol biosynthesis and identified small molecule degraders and stabilizers. Grateful for guidance by @laraialab 🙏 big thanks to Cecilia, @Laura_dta, @ERADLab and Mesut!

[Luca Laraia @laraialab]

New preprint! We discovered degraders and stabilizers of the #cholesterol biosynthesis enzyme squalene synthase, based on the same scaffold! Great work by PhD student @HoockJoseph, with support from Cecilia, @Laura_dta and collaborators Mesut and @ERADLab! https://t.co/zi8vUxpnrg