Eureka Flowers

Free speecher

[Ziv @biohackerziv]

For many people taking Methylfolate (5-MTHF) and Methylcobalamin (Methyl-B12) is the exact biological driver behind their sudden ADHD symptoms, panic attacks, sensory overwhelm, jaw clenching, and relentless obsessive rumination.

When you flood a genetically unsuited nervous system with active methyl donors, you trigger an acute neurochemical storm: prefrontal catecholamine overload, adrenergic hyper-arousal, and unchecked glutamatergic firing.

You do not have a psychiatric defect; you are experiencing an iatrogenic over-methylation crisis.

Simply switching to non-methylated B-vitamin variants resolves the cognitive chaos within days by restoring enzymatic homeostasis.

Here is the deep cellular pharmacology behind the methylated B-vitamin trap and how to fix it👇

The COMT Collision: Why Methyl Groups Trigger Adrenergic Panic

The primary reason methylated vitamins induce severe anxiety and ADHD-like scatter lies in the interaction between the methylation cycle and the Catechol-O-methyltransferase (COMT) enzyme:

• The "Slow COMT" Phenotype (Met/Met or Val/Met):

COMT is the enzyme responsible for degrading catecholamines—Dopamine, Norepinephrine, and Epinephrine—in the prefrontal cortex.

Individuals with the common "slow" COMT variant break down these neurochemicals at a fraction of the speed of "fast" COMT individuals.

They naturally operate with high baseline prefrontal dopamine and norepinephrine.

• The SAMe Flood:

Ingesting active methyl donors (5-MTHF, Methyl-B12) rapidly surges intracellular S-adenosylmethionine (SAMe). SAMe is the universal methyl donor required by COMT to catabolize dopamine.

• The Epinephrine Shunt (PNMT Activation):

While excess SAMe technically feeds COMT, it simultaneously acts as an aggressive cofactor for Phenylethanolamine N-methyltransferase (PNMT)—the enzyme that converts Norepinephrine into Epinephrine (Adrenaline).

In slow COMT individuals, this triggers an immediate adrenergic spike. Your system is flooded with peripheral adrenaline and central catecholamines that your sluggish COMT enzyme cannot clear in time.

• Prefrontal Signal Decay:

Excessive catecholamines over-saturate prefrontal Alpha-1 and Beta-1 adrenoceptors.

This blows open Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) leak channels on dendritic spines, causing the electrical insulation of working memory to completely collapse.

You feel wired, jittery, mentally scattered, and completely incapable of sustained attention—the precise presentation of severe ADHD.

Glutamate Excitotoxicity & CSTC Loop Hyperactivity (OCD & Rumination)

The mental loops, compulsive double-checking, and dark ruminations induced by methylated vitamins are driven by glutamate firestorms in the Cortico-Striato-Thalamo-Cortical (CSTC) loop:

• NMDA Receptor Hyper-Sensitization:

Excessive methyl donors alter the epigenetic methylation of promoter regions governing neurotransmitter receptors.

Surging methyl pools amplify postsynaptic NMDA (N-methyl-D-aspartate) receptor sensitivity.

• The Astrocytic Glutamate Reuptake Failure:

Simultaneously, the sudden adrenergic overload drives astrocytes into an energetic crisis.

The EAAT2 (Excitatory Amino Acid Transporter 2) pumps stall, leaving tonic glutamate lingering in the synaptic cleft.

• The Ruminative Loop Locks In:

When tonic glutamate continuously stimulates hyper-sensitized NMDA receptors in the CSTC loop, the brain fails to filter out intrusive cognitive noise.

A single negative scenario, irrational health fear, or social interaction echoes endlessly between the cortex and thalamus.

You cannot "rationalize" your way out of it because the underlying electrical circuit is physically locked open by excitotoxicity.

Histamine Clearance Crashes: The Paradoxical Flare

Many people experience sudden somatic symptoms on methyl donors: insomnia, racing heart, skin flushing, and allergy-like flares. This is driven by destabilized histamine kinetics:

• Histamine N-Methyltransferase (HNMT):

In the central nervous system, histamine is broken down exclusively by HNMT, an enzyme that requires SAMe.

• The Feedback Inhibition Bottleneck:

When massive doses of methylfolate enter the cell, SAMe surges violently.

However, high SAMe rapidly downregulates MTHFR via feedback inhibition and can cause a transient accumulation of S-adenosylhomocysteine (SAH) if downstream clearance is slow.

SAH is a vicious, potent competitive inhibitor of methyltransferase enzymes—including HNMT.

• The Histamine Rebound:

Inhibiting HNMT causes central histamine concentrations to spike.

Histamine stimulates H1 receptors in the hypothalamus, driving relentless nocturnal wakefulness, high-alert paranoia, and autonomic agitation that mimics severe generalized anxiety disorder.

The Non-Methylated Replacements: The Surgical Pivot

You still need folate and B12 to synthesize cellular ATP, maintain red blood cells, and fuel the Krebs cycle. You simply must use forms that allow your body’s internal enzymatic feedback loops to control the rate of methylation, rather than forcing methyl groups into the cell:

• 1. Replace Methylfolate with Folinic Acid (Calcium Folinate):

The Mechanism: Folinic acid is a non-methylated, metabolically active form of folate (5-formyl-tetrahydrofolate).

It bypasses the MTHFR enzyme entirely, feeding directly into the folate pool to produce purines and thymidylate for DNA repair.

It converts into 5-MTHF only downstream, strictly on demand, governed by cellular feedback mechanisms. It supplies every biological benefit of folate with zero methyl-donor spiking.

• 2. Replace Methylcobalamin with Hydroxocobalamin or Adenosylcobalamin:

Hydroxocobalamin: A non-methylated precursor that readily converts into active B12 forms intracellularly as required.

Critically, Hydroxocobalamin acts as a natural Nitric Oxide (NO) scavenger, mopping up toxic peroxynitrite and calming systemic neuroinflammation.

Adenosylcobalamin (Dibencozide): The mitochondrial form of B12. It acts as the specific cofactor for Methylmalonyl-CoA Mutase, directly fueling the Krebs cycle and fatty acid oxidation inside the mitochondria without introducing a single methyl group into the cytoplasmic methylation cycle.

[Jeffrey A Tucker @jeffreytucker]

Want more from the relentless revelations of how fake much of the world is? Read this amazing story in Nature on the amazing number of fake societies of high prestige, complete with fake boards and fake meetings with fake pictures and fake buildings, all to collect dues! https://t.co/8QXLAUpIoN

[Walter Kirn @walterkirn]

Say you were stalked not by one person following you but by a series of relays between many lookouts who are standing still with phones and working together.

It's still stalking.

That's how Flock does it.

[Austin Justice @AustinJustice]

AUSTIN MAN was released from jail on a plea deal from DA Jose Garza's office. Days later, he broke into a South Austin home and walked into the bedroom where the homeowner was sleeping.

The homeowner shot him dead.

Dmario Jones, 24, was already well known to prosecutors. In May, he was hit with three felonies: organized criminal activity, felony theft, and felony criminal mischief for thousands of dollars in damage.

Garza's office threw out the organized crime charge. Then it dropped the criminal mischief charge. On the theft, prosecutors let him plead guilty and gave him a misdemeanor-level sentence.

He was back on the street within days. One week after the plea, a homeowner woke up to a burglar in their bedroom.

Prosecutors had three felonies and a chance to keep him off the street. They let him go, and a homeowner had to stop him instead.

[Rand Paul @RandPaul]

We found emails between Anthony Fauci and his assistant describing gain-of-function programs we didn’t know existed. This is why I’m focused on getting to the bottom of what really happened, so we can prevent this dangerous research from sparking another pandemic.

https://t.co/87WmAMGHdq

[Mary Talley Bowden MD @MaryBowdenMD]

This is amazing. My cardiologist friend works for a company that allows employees to opt out of a flu shot because “I do not believe the vaccine will prevent me from getting the flu.”

[Del Bigtree @delbigtree]

A world-renowned infectious disease doctor sat across from me at dinner, intending to prove me wrong, and ended up telling me I was right instead.

I was touring with Vaxxed when someone connected me with Dr. Marcus Zervos, head of infectious disease at Henry Ford Health, one of the most prestigious research institutions in the world. The first thing he told me was that he'd watched Vaxxed, found it compelling, but took issue with something I kept repeating on the road, that no proper safety science had ever been done on childhood vaccines. He said he sits on some of the largest medical databases in the world, and he'd gone and researched it specifically to show me I was wrong.

Then he told me he was shocked to be sitting across from me admitting I was right. Not one safety study using a placebo has ever been conducted on any childhood vaccine we give our children. He made a point of clarifying that this doesn't mean vaccines are unsafe. It only means we have no basis to claim that they are safe.

That distinction is exactly what I'd been saying the entire time. Why has this one product never gone through the same testing every other drug has to pass?

Go watch the film. Share it with your friends. It's there for everyone. https://t.co/yo9AE3lnOC

@bcrawforddc

[ATX data @data_atx]

Austin councilwoman Krista Laine yesterday says she is proud to support funding art workshops that she says prevent violence and reduce costly later police interventions

There is really no data that art classes reduce violence. In fact, this has been studied pretty heavily, a survey of the data in 2024 (Campbell Systematic Review) found that:

"There is no clear evidence for the effectiveness of arts interventions for CYP who are at-risk of or who have offended, for behavioural (actions), psychosocial (emotional and cultural), cognitive (logic/thought) and offending outcomes."

[Wall Street Apes @WallStreetApes]

WOAH 🚨 Senator Josh Hawley says that Flock Safety Cameras admitted to him in a private message they are saving images of every American inside their vehicles and they can search those images BY PEOPLE, not license plate

Hawley says this is a mass surveillance network like we’ve never seen being setup right here in America at a very shockingly fast pace

He says Flock is also searchable by bumper stickers on vehicles, like Trump stickers or NRA or pro-life or anything. Flock is using AI to be able to identify people down to the bumper stickers on their cars, even dents

“Flock's cameras can even recognize whether people are in the images. And in fact, Flock admitted in a letter to me ahead of this hearing that you could search their database based on people's images. You could ask to search people, images that had people, images that are scanning the the inside of the cars. I mean, this is really quite extraordinary”

“What seems to make these networks unique is not just the sheer number of cameras, it's the fact that they're all linked together and powered and searchable by AI. It's unlike anything we've ever seen in this country before — They store and catalog details like the vehicle's make, model, color, location, date, time. Flock's searchable features include details like dents and roof cracks and vehicle damage and racks on the roof or racks on the back or specific bumper stickers even. You think about that. I mean, Flock can tell you if a car has a Trump sticker or a Harris sticker or a Pro-Life America sticker or an NRA sticker.

It's really quite extraordinary.”

Just so you can get a sense of how truly vast the mass surveillance network already is in America with Flock cameras I included the current September 2026 map of all Flock cameras installed. It is insane

Why is this being allowed to happen

[Eureka Flowers @Brooksms3000]

https://t.co/gnlJeo5pDl

[ATX data @data_atx]

DEI is being put into every Austin city department

The watershed department (the guys who work on projects to prevent flooding) presented yesterday.

Instead of prioritizing work by 'worst problem first', they now use equity, community health, and 'lived experiences' of neighborhoods to decide what projects to do 👀

[Eureka Flowers @Brooksms3000]

@JacobJacobs7456 @wottheberry Concerned but also impressed!!

[General Mike Flynn @GenFlynn]

As many times as I’ve seen this video, I still can’t get past how much has changed in such a short period of time. History will not be kind to those people and organizations that caused this dramatic change.

[Isabel Brown @theisabelb]

When people say we're living in 2 different Americas, nothing could illustrate that better than this lesbian bar mask mandate story out of Massachusetts.

This communist lesbian bar in Greenfield, MA is $50,000 in debt because they don't enforce payment from "unhoused" patrons, and was originally founded by three friends including a drag performer who uses it/it's pronouns as a haven for "d**es, transsexuals, gender freaks, workers, and their friends."

The bar is in so much financial trouble that two of the original three founders have moved on -- one to become a drag queen full time and the other to pursue (literal) CLOWN COLLEGE.

The one founder left is sleeping in her car and currently in fear for her life from her own customers, who have accused her of racism, ablesim, eugenics, and more when she announced that for the first time since COVID, *one* night a week at the bar would be optional for N95 masks, which otherwise have been required inside 24/7.

South Park could not have written a better episode.

[austinreform @austinreforms]

The hour is late, and the dice are cast.

Austin is being hollowed out by institutional grift, skyrocketing crime, and a political class intentionally managing us into municipal decay.

If voters don't turn out this November, we're in for two more years of decline.

This isn't just another election cycle; it’s the battle for the soul and future of the city.

We've highlighted five city council candidates that can turn the tide -- as well as mapped out where they stand on key issues like homelessness and public safety.

https://t.co/RJXnhnU1b6

[Andrew Zywiec, M.D. @AndrewZywiecMD]

"My teenager was born in the wrong body and actually has the brain and soul of the other gender. We must drug them and cut off their genitals."

Doctor: I believe you. And you are correct. The science is on your side, and I do not have to do any confirmation. This all checks out.

"My infant took the MMR vaccine, and within 45 minutes had several seizures and has not made eye contact since. They also stopped speaking and seem to be in distress."

Doctor: This is just a coincidence. Your child seems fine to me, and infantile seizures are nothing to worry about. He probably just has autism, which is not in any way related to the vaccine. The seizures are also not linked to the vaccine. I know the inserts say that both seizures and autism are linked, and common sense would dictate that a seizure right after a vaccine that resulted in neurological changes could all be related, but it's not. The inserts information is just them being cautious, for liability sake, even though they have legal immunity from liability, because the products are so safe they require federal shielding. Does all of that completely incoherent and inconsistent information make sense? Good.

[Mary Talley Bowden MD @MaryBowdenMD]

Trump won because Kennedy brought him the medical freedom votes. And now both of them have lost our support. The midterms will be interesting.
@SecKennedy and @POTUS it’s not too late to do the right thing.

[TaraBull @TaraBull]

Florida Woman Held 86 Hours in Solitary After Flock Camera Falsely Linked Her Car to Deadly Crash

Lindsey Isaacs spent nearly two weeks in maximum-security jail before charges were dropped.

[Steven Phillips, MD @StevePhillipsMD]

PANS/PANDAS mechanism just published: (They studied strep but it's not limited to strep, I've seen many cases from bartonella)

Strep → IL-17A → microglia → leaky blood-brain barrier → sudden personality changes, OCD, tics, & many more.

For 20 years parents were told it was psychosocial.

It was inflammation due to an infection. It always was.

[Mary Talley Bowden MD @MaryBowdenMD]

Today I got to see the patient who gave me the courage to treat even the most severe Covid patients as an outpatient. He walked in with an oxygen saturation of 62% and refused to go to the hospital. Even after 8 days, his oxygen saturation was only 83% on room air. I treated him with high dose ivermectin, steroids, spironolactone, high dose IV vitamin C, azithromycin, fluvoxamine, glutathione, and home oxygen. Slowly but surely he stayed out of the hospital and survived. He is one of the stars in my book.