BurkeLab

Exploring and Exploiting the Functional Capabilities of Nucleic Acids

[Suess Lab @suess_lab]

New Paper out! In cooperation with the Wöhnert Lab in Frankfurt and @ABousseb

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Hanadi Sleiman @SleimanHanadi]

If you’re into DNA, go to minute 13-14. This is so cool!

[BurkeLab @BurkeLabRNA]

@benoitbruneau @bthomasZOU

[BurkeLab @BurkeLabRNA]

Almost all our pubs are collaborations...

We just submitted a great piece yesterday. Collaborator wrote to me:

"It's a productive collaboration between your lab and mine. Neither lab alone would have achieved what we got."

... and that's why. 😃

[BurkeLab @BurkeLabRNA]

Structural mechanisms of HIV-1 capsid lattice stabilization

[Sarafianos Lab @SarafianosLab]

Oooff! This one tested our limits (7 Xray structs, molec-dynamics simulations, cryoEM, timeresolved imaging, biophys/biochem to elucidate how mutations enhance/reduce HIV core stability, thus impairing infectivity & how 2ndsite mutations rescue infection. https://t.co/ZD8h85WMr7

[BurkeLab @BurkeLabRNA]

Keeping my distance from 'X' these days. Hence the silence.

What alternative social media platforms are ppl using these days?

What makes it 'better' (apart from absence of the distasteful parts of 'X')?

[Claudia Höbartner @HoebartnerLab]

#SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a novel propargylated nucleotide in RNA. Check out the full story https://t.co/Y4yPDxe3oI
https://t.co/XRzE1CdcpY

[BurkeLab @BurkeLabRNA]

@jackcschultz @DamonLisch We understand the world through our models of how it works

Hypotheses are predictions that illuminate the model.
If…then.

Gotta shake it!

If the model breaks when we shake it, it needs more thought

If we can’t break it — ie the model makes good predictions — it may be useful

[BurkeLab @BurkeLabRNA]

I think I’ll spend tomorrow ‘Writing.’

[PHD Comics @PHDcomics]

Things you can do in Academia

[BurkeLab @BurkeLabRNA]

@OdedRechavi All of biology is interconnected Rube Goldberg machines

Omit a piece and see whether you can guess the missing piece without referring to an analogous system

‘Tis humbling to those of us who would build new biologies or study its origins!

#SynBio #OoL #Astrobiology #RNAWorld

[The Nobel Prize @NobelPrize]

Happy pi approximation day!

Today's date, 22 July, can also be written as the fraction 22/7, which is equal to 3.14285714, an approximation of π, correct to two decimal places.

[BurkeLab @BurkeLabRNA]

@sonukg4india Clock

[BurkeLab @BurkeLabRNA]

@AmitKahana Sooooooo maaaany proposals fail to allow for a meaningful outcome in which an informative null hypothesis could prove their core ideas to be wrong.

Those proposals don’t score well.

[BurkeLab @BurkeLabRNA]

@IvaZovkic WestWorld prototypes.

[BurkeLab @BurkeLabRNA]

@jackcschultz @ADHansonLab I’ll bet that @jackcschultz has a few examples …

[BurkeLab @BurkeLabRNA]

“Life is chemistry that remembers.”
— Karyn Rogers

[Saurja DasGupta @SaurjaDasGupta]

@xai How did Chemistry become Biology?

[Saurja DasGupta @SaurjaDasGupta]

@BurkeLabRNA A Biochemist and a Geologist walk into a bar and try to solve the origins of life problem.
Bartender to them: how on earth did life begin?
Them: Exactly!

[BurkeLab @BurkeLabRNA]

@OxonAndrew @ThePhDPlace Cardinal rule in my lab. Do not reinvent the wheel ripping apart peer-reviewed, published research papers just for making a dissertation chapter.

Adjust figure numbers (eg, fig 4 ➡️ fig 3.4 of chapt 3). Insert SI somewhere logical and findable. IDC where. Keep refs as is. Go!

[BurkeLab @BurkeLabRNA]

@munozfortik Pitch it. Pitch it good.

[BurkeLab @BurkeLabRNA]

@SaurjaDasGupta Another of her quips:

“A Biochemist and a Geologist walk into a bar and try to solve the origins of life problem. Not a joke. That’s just what we do!”

Karyn Rogers, describing PCE3 (Prebiotic Chemistry and Early Earth Environments, one of NASA’s RCNs.

#OoL #Astrobiology