🇦🇺 now in 🇺🇸Formerly @Perf_Genetics & now Director of Research & Development @StableAnalytics . Bought a few fast racehorses using my 👁️ & ML data models
Novel serum biomarkers provide evidence for an involvement of the CCL3:CCL5 axis in fatal musculoskeletal injuries in Thoroughbred racehorses - https://t.co/nTaMU43bGu
@frankfinnegan3 He may well be the right person for the job, and well capable of doing it, but a quasi-government company not opening it up for outside candidates, especially after a way-too-long CEO tenure, doesn’t pass the smell test at all.
Maternal care style in the Thoroughbred horse is linked to genetic variation at the glucocorticoid receptor gene (NR3C1) locus - https://t.co/7RIU5cGbqD
@byronrogers73@jdreams93@StableAnalytics So the conclusion is find the Double Gene, go to town with Danehill and Galileo in the heart of the Pedigree as it is with ND & MrP. Search for the code & that then opens up your eyes . E.P Taylor found it , curtesy of Federico Tesio
@byronrogers73@jdreams93@StableAnalytics It's like the sheep leading the Shepherd. When are the Breeding Family going to take in that when A Horse carries the Double Gene it enhances their chance of success 5 fold, on the Track & in the Barn .
Danehill carries the Double Gene.
Couldn't fail , hasn't failed.
We have @StableAnalytics , across over 100,000 horses born 2010-2022. A few of points worth making
1. 8 generations MASSIVELY underestimates coefficient of inbreeding. Take it to the start of the breed and most are between 10-15% inbred.
2. The COI of the individual horse isn’t that predictive of performance except as an eliminatory variable when it’s way outside the norm (too inbred or not enough). There’s way more information on the subject horse’s COI relative to other ancestors in its pedigree and pairwise kinship between those ancestors (eg how closely related the sire and Broodmare sire are if mated in hypothetical fashion between them)
3. COI in any form is well behind other variables that help explain the difference between elite and non-elite horses.
I've noticed anecdotally (in the process of confirming) that a lot of good Into Mischiefs have a < 2% 8-gen pedigree COI, while there are good inbred Curlins. Has anyone ever done a large-scale analysis of inbreeding trends and their relationship to performance by sire?
Generally speaking inbreeding at 3 generations or closer is less successful than generations 4-6. The obvious exception was Danehill who was 3x3 to Natalma, but his success as both a racehorse and sire tells us that he was a rare event where his genome had purged the negative alleles associated with inbreeding (the same couldn’t be said for his full relations). This has made him a worthy horse himself to inbreed to, but still it’s not that successful until it’s out to generation 4 and beyond.
@jdreams93@StableAnalytics We have some tools @StableAnalytics coming out shortly that are helpful. There is of course a difference between what is on paper and what occurs at a genomic level, but on a population viewpoint, the COIs have some utility.