ISARIC4C

The ISARIC Coronovirus Clinical Characterisation Consortium is recruiting COVID-19 patients. Urgent public health research supported by @NIHRresearch @HPRUezi

[ISARIC4C @CCPUKstudy]

Recruitment to @CCPUKstudy stops today. We hibernate now and prepare for the next exposure of Public Health Interest. Our Outbreak Data Analysis Platform is open for research with over 303k cases of #COVID19 https://t.co/qmUCn53Xhv @kennethbaillie @p_openshaw @ProfCalumSemple

[BESS @BESStudy]

The results of the BESS trial will be announced at 14:40GMT today at the European Society of Paediatric and Neonatal Intensive Care, Alicante, Spain.

[Professor Calum Semple OBE @ProfCalumSemple]

Timely collation, linkage and analysis of data has been key to informing the public health and clinical response in outbreaks of MERS, COVID-19, and Childhood Acute Severe Hepatitis of Unknown Origin @CCPUKstudy @ISARIC1 #DataSavesLives

[ISARIC4C @CCPUKstudy]

#DataSavesLives

[Professor Chris Whitty @CMO_England]

I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research https://t.co/xaQpvPmcvV

The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.

[Professor Chris Whitty @CMO_England]

I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research https://t.co/xaQpvPmcvV

The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.

[Professor Calum Semple OBE @ProfCalumSemple]

In general, the impact of Covid-19 on causing critical illness, i.e needing intensive care, in children lessened over the first two years of the pandemic, including when the omicron variant became dominant @CCPUKstudy @ISARIC1

[Jeremy Farrar @JeremyFarrar]

@EckerleIsabella @edwardcholmes Yes, along with loss of biodiversity, changing habitats of animals, illegal wild life trade, urbanisation, trade and travel. All key drivers more frequent & complex epidemics & pandemics. The epidemic events are symptoms of our changing world & need to address the key drivers

[ISARIC4C @CCPUKstudy]

@gail_carson @ISARIC1 Outputs from @ISARIC1 and @CCPUKstudy in the UK are available for all to read without charge at https://t.co/9NqsfsGVR3 #DataSavesLives #VaccineCauseAdults

[Antonia Ho @DrToniHo]

TL;DR:

Our preprint was 1ST to report association btwn #AAV2 & hepatitis cases, found on metagenomic sequencing in 9/9 early 🏴󠁧󠁢󠁳󠁣󠁴󠁿cases vs 0/58 controls. #adenovirus found in 6/9 cases.

Cases also >likely to carry HLA DRB1*04:01 allele (8/9; 89%) vs 🏴󠁧󠁢󠁳󠁣󠁴󠁿blood donors (16%) 2/

[ISARIC4C @CCPUKstudy]

Doctors, scientists, & public health teams are working together, learning lessons from their responses to past outbreaks pandemics. This new way of working has led to the rapid discovery of the cause of this mystery disease @ISARIC1 @kennethbaillie @ProfCalumSemple

[Antonia Ho @DrToniHo]

🌟Proud to share our paper 'Adeno-associated virus 2 infection in children with non-A-E hepatitis', out in @Nature today!🌟

https://t.co/ccdKNzJN2C

@CVRinfo @UofGlasgow @P_H_S_Official @RHCGlasgow @CCPUKstudy

A🧵highlighting key updates from preprint released in July 2022 1/

[Peter Openshaw @p_openshaw]

U.S. FDA Advisory Committee (VRBPAC) voted support the safety and effectiveness of GSK AREXVY™  (RSVPreF3 OA), 12-0 on effectiveness and 10-2 on safety.

https://t.co/UuERkdd2wK

[ISARIC4C @CCPUKstudy]

@roslininstitute @kennethbaillie Many many congratulations @kennethbaillie Thoroughly deserved.

[Antonia Ho @DrToniHo]

Cases (n=9):
- admitted 14 March-4 April 22
- recruited to @CCPUKstudy
- 4 male; median age 3.9 (IQR 3.4-5.1)
- most had GI symptoms 1-11 wks b4 hepatitis
- no immunocompromise
- none had covid 💉
- Hep A-E, EBV/CMV, HHV6/7, HSV, autoantibodies neg
- no transplants/ deaths

2/

[Gail Carson @gail_carson]

@ISARIC1 @CCPUKstudy publication on our data platform. Thank you all partners & members for your contributions.

https://t.co/u4WJ3oUef8

[Jake Dunning @OutbreakJake]

Comment piece from David Ulaeto, Miles Carroll & me: Evolutionary implications of human transmission of monkeypox: the importance of sequencing multiple lesions https://t.co/n7nDR54mDR
We need multiple lesion samples & sequencing now to prove this @ISARIC1 @CCPUKstudy

[Antonia Ho @DrToniHo]

Timely release of our latest @CCPUKstudy study, led by @LanceTurtle, evaluating impact of #immunocompromise (IC) on outcome in hospitalised #COVID19.

TL;DR: Despite effective 💉& Rx, IC individuals remain at ⬆️ risk of death from COVID19 compared to immunoconpetent persons.

[Antonia Ho @DrToniHo]

🚨New preprint🚨

Adeno-associated virus 2 infection in children with non A-E #Hepatitis

A case-control investigation of 9 early cases in #Scotland & 58 controls.

@CVRinfo @P_H_S_Official @RHCGlasgow @CCPUKstudy @ucl @UKHSA @emcat1

🧵1/
https://t.co/Ooiu66qvoh

[ISARIC4C @CCPUKstudy]

Great result and further evidence of the value of preparedness studies set up in readiness for future outbreaks of novel disease @gail_carson (the original CI), @ProfCalumSemple (CI & coLead) @kennethbaillie (coLead), @p_openshaw (coLead), @OutbreakJake & many more

[University of Glasgow @UofGlasgow]

🆕 Recent acute #hepatitis cases of unknown origin in children have now been linked to the virus AAV2, with no evidence of a direct link to #SARSCoV2 infection, in two new studies led by @UofGMVLS @GreatOrmondSt and @UCLchildhealth.

Find out more ➡️ https://t.co/FzNYEtCOeD

[Professor Calum Semple OBE @ProfCalumSemple]

Brilliant News Jo and Team. Thank you so much for your help with @CCPUKstudy @ISARIC1

[Professor Calum Semple OBE @ProfCalumSemple]

Many many congratulations to @ShonaCMoore, winning the Outstanding Contribution During The Covid-19 Pandemic, Shona and the team in our outbreak laboratories delivered the @CCPUKstudy which saved lives and enabled discovery on #COVID19

[ISARIC4C @CCPUKstudy]

For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at https://t.co/QBAM1IO45i
@CCPUKstudy