One scaffold to a forest of molecules.Synthetic framework evolution (SFE) places persistent synthetic scaffolds at the center of molecular diversification, enabling iterative expansion of natural product-like chemical space.
Accounts of Chemical Research https://t.co/9wCRyj4OwX
Chiral pool terpenes as a starting point for diversification. The synthesis of rumphellolide K, ramphellaone A, and antipacid A is presented, all originated from (−)-caryophyllene oxide in less than 4 steps! Check it out in #OrgLett by @CIStathakis_Lab https://t.co/1sUdijyyaR
Terpenes will always fascinate me! Check out our collective syntheses of rumphellolide K, rumphellaone A and antipacid A from (-)- caryophyllene oxide all in less than 4 steps! Congrats girls Theodora, Georgia and Polina! https://t.co/UEDHtMGB6O
Lab 324 (almost) united at ACC2023! Me and @zografos_alex are really proud for our Natural Product Synthesis students and thankfull for their hard work and dedication!!!
Please check our new review on: Selective preparative ‘oxidase phase’ in sesquiterpenoids: the radical approach - now published in Organic Chemistry Frontiers https://t.co/ti37sanxid