Steven Bennett

Medicinal chemist @BioAscent | PDRA: Lawrence group @EdinburghUni | PhD: Aggarwal group @BristolUni | MChem: @UniStrathclyde | Creator of @NewInSynthesis

[Steven Bennett @SHBennett_]

Hi all, I’ve recently started a weekly newsletter focused on highlighting key papers in organic synthesis that have been published in the previous week.

If you’re interested in reading more you can find the website linked below 👇

https://t.co/oolX1LF9fV

[Steven Bennett @SHBennett_]

@RestIsPolitics @campbellclaret @RoryStewartUK MSD scrapped a £1B London R&D hub, cut 125 jobs & blasted the UK as “not internationally competitive” while AZ paused a £200M investment & scaled back a £450M expansion in the UK after Gov support faltered. Does the UK no longer value the life science sector or its scientists?

[Steven Bennett @SHBennett_]

@LabMukherjee @biomimetic_chem Thank you - I really appreciate the support!

[Andy Lawrence @biomimetic_chem]

Do you struggle to keep up with the organic synthesis literature? Our former postdoc @SHBennett_ has started the Organic Synthesis Newsletter, a fantastic weekly summary of the recent literature. I highly recommend you subscribe for this FREE resource!!

https://t.co/n0nYq7SktX

[Steven Bennett @SHBennett_]

@biomimetic_chem Thank you so much for the kind words, Andy! I’m glad people are finding it so useful - hopefully that will continue 😄

[David Jones @dJon_es]

Interested in the origins of stereoretentive enantioconvergence? @FrichardChem and I have just written a "Behind the Paper" post where we explain all - starting from @biomimetic_chem's 2012 (!) total synthesis of rac-incarvilleatone.
https://t.co/S1pVid0gYR

#OrganicChemistry

[Steven Bennett @SHBennett_]

It was a privilege to work on such a beautifully designed project and a joy to come in everyday and work with such talented colleagues, all of whom worked so hard towards this outcome! Particular thanks go to my post-doc colleagues @FrichardChem @dJon_es @VDemertz!

[Steven Bennett @SHBennett_]

Enantioconvergence with complete stereoretention.

Check out how @biomimetic_chem developed a new method for enantioconvergence and in one case joined two enantiomers of a racemate into an essentially single (99.99% e.e.) enantiomer using one branch of the methodology.

[Andy Lawrence @biomimetic_chem]

Our new approach to enantioconvergent reactions is available @NatureChemistry. We hope the community finds it interesting and we’re excited to see how others might be able to exploit this concept!
https://t.co/RVtaBKeRcM

#Stereochemistry #AsymmetricSynthesis #Enantioconvergent

[Steven Bennett @SHBennett_]

Issue #2 was just released this morning and I’ll put a link to that below but first I’d like to say thank you very much to all who have subscribed so far! I really appreciate the support and I hope this will be a useful resource going forward!

https://t.co/3LPEIgnpWf

[Steven Bennett @SHBennett_]

Hi all, I’ve recently started a weekly newsletter focused on highlighting key papers in organic synthesis that have been published in the previous week.

If you’re interested in reading more you can find the website linked below 👇

https://t.co/oolX1LF9fV

[Steven Bennett @SHBennett_]

I’ve also started @NewInSynthesis to provide more information on the newsletter as well as to share posts and updates going forward.

[Steven Bennett @SHBennett_]

@lvicensserra Thank you Laia! That’s far too kind! I really appreciate the support - hopefully it will be a useful resource 😄

[Steven Bennett @SHBennett_]

@dJon_es Thanks very much for sharing and for the kind words David! Hopefully it will prove useful to some!

[That Chemist @That_Chemist]

A New Synthesis of Beraprost
https://t.co/xfNdvVApc3

[Varinder Aggarwal 🇺🇦🇺🇦🇺🇦 @VarinderAggar11]

The serendipitous discovery of a t-BuLi mediated dehalogenation-aromatization reaction enabled the total synthesis of Beraprost and set the stage for a unique approach to the modular synthesis of indolines. Congrats to the team who put so much into the project @SHBennett_

[Steven Bennett @SHBennett_]

@willwh_ @J_A_C_S Thanks Will! It was really cool to see that deuterium shift occuring, maybe even opens up the possibility for other non-H/D 1,2-shifts!

[Steven Bennett @SHBennett_]

Great to see this out in @J_A_C_S! The serendipitous discovery of a t-BuLi mediated dehalogenation-aromatization reaction really facilitated the total synthesis of Beraprost and set the stage for a unique approach to the modular synthesis of indolines.

[Varinder Aggarwal 🇺🇦🇺🇦🇺🇦 @VarinderAggar11]

An unusual elimination reaction, via a carbene intermediate, enabled a novel aromatization process for the synthesis of indolenes and dihydrobenzofurans and paved the way for a short synthesis of beraprost. Congrats to the team. @BristolChem @SynthAtBris @J_A_C_S

[Andy Lawrence @biomimetic_chem]

Check out our new pre-print that shows you don’t need labile stereogenic units to achieve stereoconvergency! https://t.co/SQRSuOEGXr Stereoretentive-enantioconvergent reactions represent a new approach to #AsymmetricSynthesis.

#Chiral #Catalysis #Enantioconvergent

[Steven Bennett @SHBennett_]

I had a great experience working with Andy and his group - the depth of knowledge and quality of chemistry there is incredible and I can’t recommend them enough.

I look forward to seeing what comes out of the group in the future and starting a new career @BioAscent!

[Andy Lawrence @biomimetic_chem]

Today we bid farewell to two amazing postdocs.

@SHBennett_ joined us from @AggarwalLab and is now heading for a job @BioAscent

@FrichardChem joined us from @arseniyadis and is now heading for a second PDRA @Gaunt_Group

Good luck guys and thank you!

[Varinder Aggarwal 🇺🇦🇺🇦🇺🇦 @VarinderAggar11]

Thank you for validating a cool procedure for aldol and dimerisation of succinaldehyde in very high ee. Very useful for prostaglandin synthesis and other 5-ring carbocycles. @DirkTrauner @SynthAtBris @Organicsynthes_