🚨 New in @JClinInvest 🚨
HPV+ oropharynx patients do not all benefit equally from the same radiation dose.
Our study shows that genomics (via GARD) can guide personalized RT de-escalation—safely sparing toxicity without losing cure.
Paper 👉 https://t.co/TEOh9q6qYQ
#ASTRO25
Promise and Challenge of Personalized Lung Cancer Screening: thoughtful @JCO_ASCO editorial by @WilmotCancer Associate Director Patricia Rivera. https://t.co/7ICfT8VmSp
1/ There are a ton of cool papers coming out on evolutionary transitions in individuality right now! Here are five recent ones I've really enjoyed, spanning Snowball Earth, volvocine algae, plasmids that fuse into a new individual, the relatives of animals, and... water kefir
Ecology is 100% more on the data side of things than the proof side of things. Ecological theory is relatively simple and coarse-grained, and the data noisy, highly context dependent, and often overly short term. For more on why long-term datasets are essential: https://t.co/AccHHzdCQq.
I think ecology is quite safe from AI
Excited to be recruiting a postdoc to come to Seattle with me in January 2027! We'll develop data-driven methods with machine learning, genomics and biostats/statphys to study pressing questions in cancer biology!
🚨⭐️HOT OFF THE PRESS👉Pleased to share our new paper, led by the amazing @JulianaRBeal@niamhjcoleman@JiaJennyLiu
👉Precision before incision: neoadjuvant tumor-agnostic therapies.”
👉Nine tumor-agnostic drugs now have a case for earlier use, before resistance sets in and with organ preservation in mind.
👉A PD-1 blockade hit a 100% complete response in MMR-deficient rectal cancer. 🧬 @JasonSicklick@OncoAlert@oncodaily https://t.co/4uMOtFRm1O
#PrecisionOncology
Excited to share our new paper with @Mitch_P and @Luke_Pike_MD@pike_lab!
Nearly 4,000 brain mets patients treated with linac-based SRS at MSK: contemporary survival outcomes, prognostic factors, and what happens next with salvage treatment. 🧵
https://t.co/MPpxcEn8nh
1/2 #RadRes2026
Now this was illuminating, amd entertaining 😅👍
Painter Debate: ☢️what is the value of mouse experiments in radiation science❓️
@DKirschMDPhD and @CancerConnector going at it with much bravado, and wit🔥🔥
And, in David's case, as expecteded, rock solid data☺️
About 15% of ~40,000 people who developed cancer have pathogenic (disease-causing) genome variants (PVs) when their DNA was sequenced.
That's a big proportion of cancer that would set up prevention or very early detection which is completely missed today @AACR@CD_AACR
https://t.co/g8Bbl4FuIq
Excited to be back @MIT tomorrow for a seminar @kochinstitute!
Hosted by my undergrad mentor Phillip Sharp, who inspired my path as a physician-scientist.
Sharing our journey from early detection → ctDNA MRD → functional liquid biopsy & Liquid Ecotypes for precision oncology.
Do animal models still earn their place in radiation research? @CancerConnector vs. @DKirschMDPhD at #RRS2026 will test it. Expect strong opinions on translation, failure rates, and what we'd lose without them.
Update: for anyone interested in the discussion @nntaleb and I are having about @stephen_wolfram's work on prisoner's dilemma tournaments, the state of the art is beautifully summarized by Joshua Plotkin (among the world's leading experts on all of this): https://t.co/E6SvoL6uYQ