Cascales Lab

How to specifically select a protein from one side of the membrane and to transport it on the other side ? That's what we will love to understand. #T6SS #T9SS

[Cascales Lab @CascalesLab]

@DrDorSalomon Happy anniversary !! What a decade !! Congrats !

[Cascales Lab @CascalesLab]

This work complements the study of Jùlia Alves, José da Silva Neto and @SarahCoulthurs1 published earlier this year: https://t.co/vMApjg7S46

[Cascales Lab @CascalesLab]

New study in @NAR_Open 🧬
A #T6SS-delivered Rhs toxin from Chromobacterium violaceum, TreThr, is an ADP-ribosyltransferase that selectively modifies charged tRNAThr(GGU), blocking ACC codon decoding & shutting down protein synthesis in rival bacteria.
https://t.co/YV8XUMXDFI

[Cascales Lab @CascalesLab]

New in @CurrentBiology 🦠 Why do bacteria ditch their T6SS weapon? Experimental evolution shows that E. coli keeps it vs susceptible rivals, but loses it when facing immune ones. Great work @bTaillefer_ @JonasDesjardins!

https://t.co/4U51GsKL2c

[Cascales Lab @CascalesLab]

@_Wienman_ Yeah !!

[Cascales Lab @CascalesLab]

Very proud to see our review "Anti-type VI tactics: bacterial defenses against T6SS attacks" featured on the Cover of @TrendsBiochem
https://t.co/vknJPnkd4X

Kudos to @NicolasRivard11 for creating this fantastic Cover illustration!
But… do do you recognize the original painting?

[Basler Lab @Basler_Lab]

Interested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab:
https://t.co/2cnF90exE6

[Cascales Lab @CascalesLab]

Happy to share our latest review on the "Structure and function of the #T9SS for protein secretion and cellular motility" to be published in the incoming volume 80 of Annual Review in Microbiology.

Kudos to Yaelle Aouizerate and @doan_thierry !

https://t.co/ZzYo47MZFs

[Erh-Min Lai @erhminlai]

Our lab is recruiting people at multiple levels: postdoc, graduate student, and RA @IPMBSinica #Taiwan to investigate the evolution and molecular mechanisms of #Agrobacteria #T6SS antibacterial weapon. Check out the job ad and the lab website! Please apply or RT

[Cascales Lab @CascalesLab]

Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !

📅 Secretion Days 2026: October 8-9 in Marseille 🌊
🎤Invited speaker : Wilbert Bitter; @wilbertbitter
🆓 Free !
📥 Register here:
https://t.co/UtXJO2dnIZ

[Cascales Lab @CascalesLab]

Happy to share the last publication of @bTaillefer_, showing that #T6SS heterogeneity is an attenuation strategy to optimizes the trade-off between competitive killing and survival. @PLOSBiology

https://t.co/xfT9TZiuAa

[Cascales Lab @CascalesLab]

Happy to share the last work of Jonas @JonasDesjardins, identifying and characterizing a novel Rhs NAD(P) glycohydrolase delivered by the #T6SS of the major cosmetic contaminant, Pluralibacter gergoviae.

https://t.co/LZwsqxYdlu

[Marc Erhardt @Salmo_Lab]

Postdoc opening in my lab @HumboldtUni!

Join our Einstein Foundation-funded collaboration with the Hebrew University of Jerusalem on T3SS, spatial RNA localization, imaging & bacterial cell biology.

📅 Apply by 2 June 2026
🔗 https://t.co/ucKBG42Md1

#Postdoc #Microbiology

[Cascales Lab @CascalesLab]

T2SS ? T4SS ? CDI ? T6SS ? T7SS ?
NO ! The #T9SS is also involved in interbacterial competition !! @CurrentBiology

Great work by Maelle Paillat @maelle_paillat under the supervision of Thierry Doan @doan_thierry

https://t.co/yNTxTeTar9

[Nicolas Rivard @NicolasRivard11]

Glad to share our latest review on the diversity of defense mechanisms against the T6SS!
“Anti-type VI tactics: bacterial defenses against type VI secretion system attacks” is available in Trends in Biochemical Sciences right now.
@CascalesLab
@jpcotelab
https://t.co/AwGFs18hoO

[Cascales Lab @CascalesLab]

Very happy that our work on the T6SS ADP-ribosylcyclase toxin made the Cover at JBC
@jbiolchem ! Congratulations Julius @MartinkusJM for designing this Cover !
@DukasJu
@LaurentTerradot

[Cascales Lab @CascalesLab]

Happy to share the last work of Julius (@MartinkusJM) led by Dukas Jurenas. Poly-immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @CurrentBiology
Kudos !!
https://t.co/zrfHv0fwAT

[Cascales Lab @CascalesLab]

Happy to share the last paper form the lab:
"Specialized shuttle proteins recognize T9SS signals and target effectors to their final destinations".
Great work by @maelle_paillat, led by @doan_thierry in collaboration with @StephaneAUDEBE1 @LISM_CNRS_AMU
https://t.co/hqrQDNd7Or

[Cascales Lab @CascalesLab]

Applications closing tonight (midnight French time) !!! Still a few hours to apply !!

[Cascales Lab @CascalesLab]

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
https://t.co/9Wo4R9UawC

[Cascales Lab @CascalesLab]

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
https://t.co/9Wo4R9UawC