MRehMan

Recently honors BSc at Ualberta, I do animation and art. interested in chromatin biology and synthetic genomes. Open for commissions, and ideas. DMs open

[MRehMan @_Wienman_]

tap to reveal protein

[MRehMan @_Wienman_]

I used to think that these automatic lab staff, were going to be stuck in the realm of well plates and basic imaging. But Ginkgo is REALLY impressive with what they have achieved. I look forward to its future

[Jason Kelly @jrkelly]

Very jealous of the first crop of bioengineering PhDs who will do all their lab work via autonomous labs.

[Neil Renic @NC_Renic]

Academic journals when you try to access the article you authored

[Akos Nyerges @AkosNyerges]

My lab is looking for a🚨Research Assistant🚨.

Using synthetic genomics and protein engineering, we'll design microbes and proteins with New-to-Nature functions.

Job ad and details below. RTs are much appreciated!

[MRehMan @_Wienman_]

Lol fun little game, if you think you remember all the canonical amino acid structures. Works on mobile

[Ribosome Studio @RibosomeStudio]

The little ribosome game is coming along :)

[MRehMan @_Wienman_]

Great cover page!

[Waggoner Lab @LabWaggoner]

Genome in motion: Mapping the nucleus in health
@YNusinovich @dijiang319 @sarah_h_ross
@ScienceMagazine @ScienceAdvances
https://t.co/inG44W9Nyh

[MRehMan @_Wienman_]

@mgdurrant @mgdurrant the application is closed now, does this mean an applicant has been chosen?

[MRehMan @_Wienman_]

Very interesting research out of @JohnsHopkins. Using the non-canonical amino acid ANAP to label stress granules, ANAP integrates in the protein chain using an orthogonal tRNA-Aminoacyl tRNA synthetase pair.

https://t.co/1qAfY1t8FC

[terminally onλine εngineer @tekbog]

cant believe mathematicians are going to lose tens of jobs because of AI

[MRehMan @_Wienman_]

Another good paper, currently a preprint. Looking at protein switches

https://t.co/EceFQPqqeq

[MRehMan @_Wienman_]

I don't see this often, a graphical abstract with rendered 3D proteins, incredible!

[Molecular Cell @MolecularCell]

Online Now: Yeast Rad55–Rad57–SHU paralog complex dynamically promotes Rad51 filament formation https://t.co/0qpxN4Hs5c

[MRehMan @_Wienman_]

Just read this, absolutely incredible paper for anyone interested in AI assisted directed evolution

[David R. Liu @davidrliu]

Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned starting points consistently evolve an expanded fitness landscape, reaching new function with higher activity, specificity, and stability than their natural counterparts.
https://t.co/pNlw6z1zvU
1/14

[MRehMan @_Wienman_]

amino acid tierlist, histidine and tryptophan top ranked imo

[Bo Wang @BoWang87]

Science Twitter is so back!

[MRehMan @_Wienman_]

Whenever I see Petunia's I always remember being in a 2nd year uni course and being told that RNAi was first found in petunias in 1986 but they didn't find the mechanism for it 😔

[Nick Desnoyer @NickDesnoyer]

I found that H2O2 treatment of Petunia flowers creates a "nightsky" like pattern 😯

It's known oxidation degrades anthocyanins, but the pattern was unexpected!

[MRehMan @_Wienman_]

Been looking more RFdiffusion stuff and saw some animations which use the Xo and Xt structures to visualize the process, such as here on the @chaidiscovery homepage https://t.co/xTWSBOL5KF

Heres the series of Xo structures over time, will try to recreate the one on the site

[MRehMan @_Wienman_]

@broadinstitute @JD_Buenrostro Known for developing ATAC-seq, so heres a key protein involved in the process, the transposase Tn5

[MRehMan @_Wienman_]

Great writeup by the Leah Eisenstadt at the @broadinstitute on Jason Buenrostro @JD_Buenrostro about his career. Touches on being first generation and the struggles. Very good!

[Broad Institute @broadinstitute]

Shaped by a tumultuous childhood, Broad researcher and epigenomic tool-maker Jason Buenrostro pivots to studying the biology of stress and adversity and finding new ways to boost resilience. https://t.co/IVOzZcu5a1

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

On the cover of Cell Genomics: The image depicts a nerine flower and the spatial structure of the VDAC protein, which the program NERINE links with Parkinson's disease. Artist: Rauf Sunyaev.
https://t.co/PeM3trWUsY

[MRehMan @_Wienman_]

Protein, trying to recreate the claymation style but still not all that there but made for a good animation exercise. Check out Clockworks video, their excellent

[MRehMan @_Wienman_]

Been looking at more videos from the Youtuber Clockwork @this_clockwork, tried to recreate some of the animation, making the sort of "claymation" like animation for proteins was harder than thought. Here a simple molecule close to their style