Cassa Lab

Computational Genetics
Brigham and Women's Hospital | HMS

Developing clinical prediction methods in genomic medicine.

[Chris Cassa @ccassa]

I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews https://t.co/pIzkntNXrk 🧵

[Cassa Lab @CassaLabBWH]

Congratulations @FedeLuppi2 and @agnestothp on this impressive project to improve pathogenicity prediction using structural and epistatic features in clinically significant genes!

[Agnes Toth-Petroczy @agnestothp]

Our preprint is online: DeMAG predicts the effects of variants in clinically actionable genes by integrating structural and evolutionary epistatic features https://t.co/1WVtgdfkd4
Congrats to Federica! @FedeLuppi2 @csbdresden @mpicbg

[Sherwood Lab @SherwoodLab]

📢New work from our lab in @NatureComm! Our article describes PepSEq, a high-throughput approach to measure influences of peptide fusion on prime editing efficiency.
🎉Joyful effort by members of our lab led by @minja_bio
https://t.co/Ep1PlqFvGz

[Cassa Lab @CassaLabBWH]

@valkanase Now you are going to get some special cat requests!

[Sherwood Lab @SherwoodLab]

New work from our lab showing that use of small molecule inhibitor can change mutational outcomes of both SpCas9-NG and KKH-SaCas9 toward 1-bp insertions.
https://t.co/i8ucO2rBvB