Sherwood Lab

We develop technologies @harvardmed that combine #stem_cell biology, #CRISPR_Cas9 genome editing screens, and #computational_biology to understand gene function

[Sherwood Lab @SherwoodLab]

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: https://t.co/C2opuEhn0Z

[Sherwood Lab @SherwoodLab]

(8/8) Plus we’re not the only ones who have realized the power of Ddd enzymes in chromatin analysis: check out the work from @brian_b_liau and colleagues combining DddA and CRISPR to dissect how sequence impacts chromatin state: https://t.co/12tNw7SORq

[Sherwood Lab @SherwoodLab]

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: https://t.co/C2opuEhn0Z

[Sherwood Lab @SherwoodLab]

(7/8) In sum, ACCESS-ATAC improves the resolution of ATAC-seq and opens up a new ability to analyze single-allele TF co-occupancy. Want to try it? Reach out-- we have built flexible experimental and computational workflows and would be happy to share reagents and expertise!

[Fusion Conferences @Fusion_Conf]

‼️⚠️Registration Deadline TODAY!⚠️‼️
Register now for the 'From Genetic Discoveries to Gene Function in Human Diseases' Conference to secure your slot and join us in Portugal from 13 - 16 July 2024 #GWAS24☀️🏌️
🔗➡️https://t.co/VIbc08tkrM

[Sherwood Lab @SherwoodLab]

We are very happy to see that our manuscript, 'Joint Genotypic and Phenotypic Outcome Modeling Improves Base Editing Variant Effect Quantification,' is now published in @NatureGenet . Congratulations @JayoungR

[Luca Pinello @lucapinello]

Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️

[Jayoung Ryu @JayoungR]

Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀!

BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake.
📰https://t.co/i0YC4lTADp (1/)

[Luca Pinello @lucapinello]

Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️

[Chris Cassa @ccassa]

I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews https://t.co/pIzkntNXrk 🧵

[Sherwood Lab @SherwoodLab]

A huge thank you to everyone that contributed to this project since we started it way back in pre-COVID times! @miahamilton5 @minja_bio @ccassa @akinci_ersin @Glettre @3xon5kip and all the members of @sherwoodlab Check out our full manuscript at https://t.co/CT5u1EddiY 16/16

[Sherwood Lab @SherwoodLab]

We are excited to share our latest publication in @CellGenomics by @miahamilton5 et al.
https://t.co/CT5u1EddiY
#Genetics #CRISPR #tweetorial
1/16

[Sherwood Lab @SherwoodLab]

We are excited to apply our pipeline to get to the bottom of the genetics of lipids and cardiovascular disease risk, unraveling new cellular mechanisms beyond LDL uptake and pinpointing genetic variant effects using more precise CRISPR tools. 15/16