Chappell Lab

RNA synthetic biology lab, Rice University

[Chappell Lab @ChappellLab]

New paper out! Introducing SynORI: synthetic, modular origins of replication engineered from one origin to enable tunable copy number and compatibility. We co-transform 6 SynORI at once, build signal-driven copy control for multiplexed reporting, and more! https://t.co/05MfLdxIBQ

[Chappell Lab @ChappellLab]

Link to paper here: https://t.co/NqTsXsfzeQ

[Chappell Lab @ChappellLab]

Honored to have RNA-addressable modification(RAM) featured on the front cover of Nature Biotech. RAM is a new reporter to measure DNA uptake in complex microbial communities using a synthetic barcoding ribozyme! Awesome collaborative project with @lauren_stadler and @JoffSilberg

[Lauren Stadler @lauren_stadler]

The Stadler and Chappell labs (@ChappellLab) are hiring a joint postdoc to join an NSF-funded project on isolating and engineering environmental plasmids for microbiome engineering applications! Email [email protected] and [email protected] to apply.

[Chappell Lab @ChappellLab]

The Chappell & Stadler Labs (@lauren_stadler) are hiring a postdoc to establish innovative tools for microbiome engineering. Apply: [email protected] and [email protected], more details below. #SynBio #PostdocJobs

[Tom Ellis @ProfTomEllis]

Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. https://t.co/6ZxfUAkNL5

[Michael Koeris @mkoeris]

📢 ALERT ALERT 📢 #BTO's monthly newsletter has dropped! Check it out for the latest and greatest opportunities over here at #BTO!

Visit the @DARPA webpage for more info: https://t.co/oddcPcy5TT

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[Ophelia @oventurelli2]

Excited to share our latest work on unraveling the role of a key metabolic pathway in human gut microbiome assembly and health-relevant metabolites—powered by machine learning! Led by the talented Yiyi Liu https://t.co/Ex0CHN910a

[Chappell Lab @ChappellLab]

@kunjapur @NatureMicrobiol Great work!

[Aditya Kunjapur @kunjapur]

It seems there are no free-living organisms known to rely exclusively on one other organism for their survival.

Until perhaps now. Check out our latest publication in @NatureMicrobiol to see how we designed an exclusive microbial reliance using GCE.

https://t.co/VyLIqAirF1
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[Chappell Lab @ChappellLab]

@LucksLab @NUSynBio @NatureBiotech Thank you!

[Chappell Lab @ChappellLab]

Nice research briefing article on our @NatureBiotech paper on recording gene transfer using ribozymes in collaboration with @lauren_stadler @JoffSilberg labs!
https://t.co/r3MxmcT5M6

[Romero lab @romerolab1]

Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)

[August Staubus @AOStaubus]

Happy to announce the our paper describing a new tool for tracking horizontal gene transfer using a splicing ribozyme has been published in Nature Biotechnology! Thanks to everyone on the team for their hard work
https://t.co/UhdKGpNNGV

[Chappell Lab @ChappellLab]

@ceronifranci @JoffSilberg @lauren_stadler Thanks Francesca!

[Chappell Lab @ChappellLab]

Check out our latest paper on using synthetic RNA memory to record gene transfer across real microbial consortia. An amazing collaborative project at Rice U between @ChappellLab, @JoffSilberg, and @lauren_stadler labs!

https://t.co/7mQVgxt2iv

[Nature Biotechnology @NatureBiotech]

Information storage across a microbial community using universal RNA barcoding https://t.co/GcwHQZU75b

[Lauren Stadler @lauren_stadler]

Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with @ChappellLab & @JoffSilberg and incredible students. https://t.co/0LdIEwwkgG

[Tom Ellis @ProfTomEllis]

Joaquin Caro Astorga's SubtiToolKit paper is published today. This cloning toolkit for Bacillus and Geobacillus was years of effort and indepedent work by @JCaroAstorga1, first in my lab and then with @erika_alden_d at the Crick. It's been a journey! https://t.co/D2SVgoHz63

[Chappell Lab @ChappellLab]

@ProfTomEllis Thanks Tom!

[Chappell Lab @ChappellLab]

Pre-print alert: Introducing SynORI: Synthetic origins of replication for customizable and controllable plasmids! Lots of cool applications like co-maintaining six orthogonal plasmids in E. coli for a week and copy-control biosensors!

https://t.co/hwHfFI4qPf