Chaput Lab

This account is run by members of the Chaput Lab 🥼 Pioneering the next generation of diagnostic and therapeutic agents 🧬

[Chaput Lab @ChaputLab]

Happy graduate commencement and congratulations to our new Drs. Erica Lee, Victoria Maola-Gross, and Mohammad Hajjar! It’s so easy to celebrate such amazing students! 🎊🙌

[Chaput Lab @ChaputLab]

Happy belated birthday to our wonderful PI, Dr. Chaput, who the lab celebrated early this week! Cheers to another great year ahead 🥂

[Chaput Lab @ChaputLab]

We love our undergrads! Our very own Pranav Das (‘26) presented his crystallography research through UCI’s Undergraduate Excellence in Research program yesterday. Keep up the great work! ✨🧬

[Chaput Lab @ChaputLab]

Congratulations to our incredible Joy Lee on her successful advancement Tuesday! We’re so excited to keep watching you shine 💪🏻✨

[Chaput Lab @ChaputLab]

Pop the champagne! 🍾 Our very own Victoria successfully defended her thesis on the evolution and structural elucidation of TNA polymerases this week! Congrats, Dr. Maola-Gross—we couldn’t be prouder!! 🎉

[Chaput Lab @ChaputLab]

The @ChaputLab holds great opportunities for undergraduates at UCI to pursue research in structural biology. Check out this article highlighting one of our star students, Gracie Ko!

https://t.co/KiKfc5Ca4Q

[Chaput Lab @ChaputLab]

Our matching XNA scientists were spotted presenting their research today during the PharmSci PhD prospective student week! ☀️

[Chaput Lab @ChaputLab]

Newly published in NAR: the @ChaputLab has demonstrated TNA’s utility in gene silencing by enhancing the cellular activity and stability of RNA-targeting DNAzymes. A big step forward towards the future of oligonucleotide therapeutics! ✨🔬 https://t.co/cIg6lpbzbb

[Chaput Lab @ChaputLab]

How does evolution reshape enzyme activity? In a recent Nature Communications paper, members of the @ChaputLab are helping answer this question through new insight on the forces responsible for shaping enzyme function. Check it out! https://t.co/MGYh4FfYUq

[Chaput Lab @ChaputLab]

Our incredible Erica Lee was named one of UCI’s annual Pharmaron Fellows! Congrats to Erica on her hard work and success throughout graduate school!

[Chaput Lab @ChaputLab]

Major kudos to members of the @ChaputLab for their recent publication in Nature Chemical Biology, pushing the boundaries of enzyme evolution with a robust and highly processive RNA polymerase! Looking forward to more exciting campaigns in 2026 🎊🧬

[Chaput Lab @ChaputLab]

Inspired by nature, chemists have spent the last 50 years systematically designing and synthesizing a vast array of sugar modified nucleic acids, so-called xenonucleic acids (XNAs). Check out this NAR review on the XNA alphabet! https://t.co/96yDW7HOUn

[Chaput Lab @ChaputLab]

Big congratulations to Clark, who recently defended his Masters thesis, titled: “Development of Improved Scalable Synthesis of Nucleoside Triphosphates.”

Well done, Clark! 🎓⭐️

[Chaput Lab @ChaputLab]

Congrats to our PhD student @MaolaVictoria, recipient of UCI pharmaceutical science’s Henry Wood Elliot Award! 👏

[UCI School of Pharmacy & Pharmaceutical Sciences @UCI_SPPS]

Big congrats to Dr. John Chaput, ranked #24 in the world in Synthetic Biology by @ScholarGPS! This Top Scholar honor puts him in the top 0.5% of researchers worldwide based on impact, citations & productivity. @ChaputLab

[Chaput Lab @ChaputLab]

John Chaput and Mano Manoharan at the Nucleic Acid Therapies meeting, hosted at Cold Spring Harbor Laboratory! @CSHL

[Chaput Lab @ChaputLab]

Congrats to our very own Dr. Esau Medina on a successful PhD defense! 🎓🧬

[UCI School of Pharmacy & Pharmaceutical Sciences @UCI_SPPS]

Our PhD students showcased their groundbreaking research at our PhD Campus Visit Poster Session! 📊✨ Prospective students had the opportunity to connect with current PhD candidates and faculty members, gaining insights into our PhD in Pharmacological Sciences program at UCI.

[Chaput Lab @ChaputLab]

Congrats to Esau Medina for his work on measuring XNA polymerase fidelity in hydrogels -- just accepted into NAR! Starting 2025 off strong!

[Chaput Lab @ChaputLab]

Jan 2025: The lab officially welcomes our newest graduate student, Alex Horton! ⭐️🧬