Chari N

Scientist at @altos_labs // PhD @AgardLab (UCSF) studying protein folding using #cryoEM // UT Austin ‘16

[Chari N @ChariMN]

Very happy to have my grad school research published! This was a really fun project driven by a great collab with @WangyrRay. How do Hsp70 and Hsp90 cooperate to unfold a client protein? How does Hsp90 refold and reactivate a client protein? How do co-chaperones help? See below!

[Agard Lab @AgardLab]

Very excited to announce our two new papers! #CryoEM structures demonstrate how Hsp70 and Hsp90 cooperate to regulate the folding and function of a model client, the glucocorticoid receptor. First authors @WangyrRay and @ChariMN
https://t.co/mGhYyTfN6M
https://t.co/6cyKLdcPt6

[Eliza Nieweglowska @ENieweglowska]

Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵

#phage #jumbophage #cryoem

https://t.co/qzrLruvhzY

[Melissa Méndez @MmendezMoran]

The jumbo-phage phi-PA3 encloses its replicating genome in a *beautiful* symmetrically flexible lattice!
Congratulations to an amazing mentor and friend @ENieweglowska
https://t.co/Fi28NMNpmg

[Chari N @ChariMN]

Congrats Eliza!!!

[Eliza Nieweglowska @ENieweglowska]

Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice!

https://t.co/nQwHJEjSNU

[Chari N @ChariMN]

@ENieweglowska @WangyrRay Thanks Eliza! 😊

[Chari N @ChariMN]

@beingSimonSays I’m guessing it was the art performance in front of the de young that was scheduled (something with colored smoke I think)

[Evita Tsiolaki @evitatsiol]

Cryo-EM amazingness!

[Chari N @ChariMN]

@nprpolitics Devastating news

[Chari N @ChariMN]

Our preprint is out! How the glucocorticoid receptor (GR) is reactivated by the molecular chaperone Hsp90 and the co-chaperone p23, revealed by cryo-EM

[bioRxiv @biorxivpreprint]

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex https://t.co/ddWglWzdbK #bioRxiv

[The North Face @thenorthface]

In response to threats to our public lands, @TheNorthFace and @Patagonia are committing an additional $100K annually to @ConservationAll.