Agard Lab

Structural Biology/Biochemistry Lab @UCSF #cryoEM
Tweets by lab members

[MSK ScienceEducation @MSKEducation]

Smriti Sangwan (@smriti_sangwan) from the @agardlab & Peter Walter labs @UCSF is about to present her research - molecular mechanisms of translational regulation.

[Agard Lab @AgardLab]

🎉🎉🎉

[Nature Communications @NatureComms]

New featured image on our homepage!
https://t.co/q0mdqcGp64

Related to this article:

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

https://t.co/8OpvsCkiFh

@ENieweglowska @AgardLab @UCSF
#phagenucleus #jumbophage #phage #structuralbiology

[Agard Lab @AgardLab]

Congratulations to Maru & team on the lab’s latest pub!

PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5.

https://t.co/lNW7DwPMSk

[Agard Lab @AgardLab]

Check out the latest preprint from @andreafossati9 and @MozumdarDeepto on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team!

#phage #jumbophage #secms

[Andrea Fossati @anfossati]

New preprint alert!

Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics.
What did we find? 1\n
https://t.co/qaQHKvkQtO

[Agard Lab @AgardLab]

Please check out our latest publication from grad student @ENieweglowska on the self-assembly of the phiPA3 phage nucleus! Congrats to the whole team! @MmendezMoran @minkbaek @UWproteindesign @yifan_ucsf @joeBondyDenomy

[Eliza Nieweglowska @ENieweglowska]

Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵

#phage #jumbophage #cryoem

https://t.co/qzrLruvhzY

[Agard Lab @AgardLab]

Check out our latest preprint! #CryoEM structures of immunophilins, FKBP51 and FKBP52, in complex with Hsp90 and the glucocorticoid receptor, demonstrating the FKBP co-chaperones directly bind an Hsp90 client to regulate client activity. From recent grad @ChariMN w/ Jill Johnson

[bioRxiv @biorxivpreprint]

Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor https://t.co/W4dyA22Ewt #bioRxiv

[Agard Lab @AgardLab]

Thank you to the bargaining teams for all their hard work! #UnionStrong @UAW

[Mehdi Mollapour PhD @MedMol]

⁦@AgardLab⁩ shared amazing data (published/unpublished) on Hsp90 chaperone complexes. ⁦@Hsp90Machine⁩

[Agard Lab @AgardLab]

High resolution cellular cryoET!

[Zhen Chen @ZhenChentccz]

We optmized in situ cryoET to achieve 6 A reconstructions of mouse sperm doublets! The unique tertiary structures allow de novo protein identification of novel sperm proteins by computationally searching in the AlphaFold2 library of entire mouse proteome! https://t.co/xxqPEVE1YR

[bioRxiv Microbiology @biorxiv_micrbio]

A family of novel immune systems targets early infection of nucleus-forming jumbo phages https://t.co/1u6lDWCcgI #biorxiv_micrbio

[FTDcwow @FTDcwow]

this just in --- our FTD CWOW website is LIVE! https://t.co/bVsOi0AjL9 Time to spread the news! Great work from our team @Karen_Shuster, @aimee_kao @YokoyamaLabUCSF @karchlab @AgardLab @metadsr_ @tauCWOW #ftdcwow

[biohub @biohub]

We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵https://t.co/nQXlQe70ak

[Agard Lab @AgardLab]

Congratulations, @MmendezMoran! #phdcandidate

[Melissa Méndez @MmendezMoran]

I’ve passed my qualifying exam—a huge milestone on my way to a PhD!

So lucky to have amazing mentors and lab mates doing incredible science and throwing even more incredible @AgardLab parties!

[Agard Lab @AgardLab]

Check out our latest pre-print from postdoc Zhen Chen @ZhenChentccz on mammalian sperm axonemes revealed by in situ cryoET!

[Zhen Chen @ZhenChentccz]

Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: https://t.co/hxlcSM72BG
Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.

[FASEB @FASEBorg]

Explore emerging research and network with peers at our Protein Folding in the Cell Conference. Organized by Manajit Hayer-Hartl @MPI_Biochem and Jeffery Kelly @scrippsresearch. Don't miss keynote speaker David A. Agard @AgardLab https://t.co/Jf0cxatSmF #PFCSRC22

[bioRxiv @biorxivpreprint]

The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice https://t.co/41TLLnfeTo #bioRxiv

[Agard Lab @AgardLab]

Congratulations to all of our authors! @ENieweglowska, Axel Brilot, @MmendezMoran, @minkbaek, Junrui Li, Claire Kokontis, David Baker (@UWproteindesign), @yifan_ucsf, and @joeBondyDenomy

[Agard Lab @AgardLab]

Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.

[Eliza Nieweglowska @ENieweglowska]

Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice!

https://t.co/nQwHJEjSNU

[FTDcwow @FTDcwow]

We've got that Friday feeling! Earlier this week, #tau2022 was a success! Our #ftdcwow team was in attendance and thrilled to discuss about Tau. @karchlab @YokoyamaLabUCSF @AimeeKaoLab @AgardLab @metadsr_ https://t.co/XNSKCsUAs0

[Quantifoil @quantifoil]

#CryoeM #CryoET has enormous potential allow researchers to study #structuralbiology in situ but low throughput limits applications. This new publication from Shawn Zheng of @AgardLab @UCSF addresses that problem and offers on-the-fly processing!
https://t.co/G4Km75ivZg