Charlie Crook

Jasjjdjd

[theriac @theriac33]

there's a nasal spray that DELETES procrastination

spray it, 20min later the wall between you and the thing you've been avoiding is GONE

it's called semax

built by the Russian Academy of Sciences

it's NOT a stimulant.
> no jitter
> no crash

this is why some people say 'it does nothing' - you didn't feel it

but it's not something you're supposed to feel

you just sit down and the work happens

it also raises the GROWTH FACTOR that keeps your neurons alive

so you're protecting your brain the whole time you use it

I hit it before:
- getting into a 8h work block i do NOT want to do
- writing documentation and training
- anything I've been putting off for a week

a couple sprays up each nostril in the morning

it's going up your nose straight into your brain, don't trust random chinese powder for that

use pharma-grade only ;)

t33

[Forever Healthy @4ever_healthy]

Get the Facts !

[theriac @theriac33]

a russian lab built a compound that tells your brain to grow new wiring

the dose is smaller than a grain of rice

it's called noopept.

piracetam's successor and the most potent nootropic in existence

by lunch you feel the obvious stuff.

recall gets fast, words come easy, the fog you didn't know you had is gone

what you don't feel is the BDNF and NGF it's spiking.

those are the growth factors that build new connections between your neurons and keep the old ones from dying off. you're sharper today and you're keeping the hardware alive for years

I take it before anything that needs me on the spot.
- supplier calls
- negotiations
- copy that has to convert

honestly I'd run it even if it did nothing same-day, just for the long game

10-20mg under the tongue

russian pharma-grade only.

you're putting this in your brain, don't cheap out on chinese powder

t33

[AutisticClips @AutisticClip]

Never kill yourself. Never give up.

[Dalton (Analyze & Optimize) @Outdoctrination]

BPC-157 is one of the most famous peptides out there - with claims it's a borderline miracle cure for anything you can name.

Here's everything we know (& more importantly, don't know) about how it works (🧵1/10):

[Abud Bakri MD @AbudBakri]

This is the best narrative article on BPC-157 that I’ve heard

Lots of details here you won’t find elsewhere

[Rory Not Sorry @rorynotsorry]

This my friends is the best pen there is... it will cost you upwards of $50 to $75 and you can't get them in the United States easily, but it is butter smooth.

[𝕾𝖎𝖗 𝕮𝖍𝖗𝖎𝖘 @eagleseyeinc]

top 10 sexiest men's colognes

1. tom ford tobacco vanille
2. parfums de marly layton
3. jean paul gaultier le male le parfum
4. dior sauvage elixir
5. bleu de chanel edp
6. dolce & gabbana the one edp
7. le labo another 13
8. versace eros edp
9. mancera cedrat boisé
10. yves saint laurent y edp

if you want to leave a statement and make time stop the moment she smells you, own at least one fragrance from this list, buena suerte 👍

[Martin Lewis @MartinSLewis]

If you want to understand how the new 22% tax on cash interest in shares ISAs or what it means for your Lifetime ISA or Help to Buy ISA with the new first time buyer ISA launching do give this a listen. I go through it step-by-step

[Anagen💈 @anagenxyz]

A hair loss company just raised $100 million from Eli Lilly.

Lilly wrote a $40 million check itself.

The drug, ABS-201, is an AI-designed antibody that blocks the prolactin receptor.

The science is real. The data underneath the hype is the problem.

Prolactin is not just a pregnancy hormone. Your scalp follicles carry its receptor, and prolactin pushes them into the regression phase early (Foitzik 2006). In mice, knock that receptor out and they grow longer hair (Craven 2001).

So blocking it is a real idea. Follicles may stay in the growth phase longer, and it never touches DHT.

But here is what should slow you down.

We have been able to lower prolactin for decades. Cabergoline does it, cheaply, in a pill. It does not grow hair, because the prolactin that matters is made inside the follicle, not in your blood.

And this is not even AbSci's idea or the first prolactin receptor antibody to enter humans.

A company called Hope Medicine built the first prolactin-receptor antibody for hair, HMI-115, years ago.

Its entire efficacy case is one Phase 1b: 12 men, open label, no placebo, about 14 more hairs per cm2 versus baseline. Worse than Minoxidil.

Then they ran the real test. 192 men, randomized, placebo-controlled, hair count as the primary endpoint. It finished in November 2024.

The results have never been released.

And it is not that the company went dark. They published the same antibody's endometriosis trial in The Lancet last month. The hair trial, finished a year earlier, has said nothing.

When a company publishes one result and buries the other, the silent one is rarely the winner.

Meanwhile, AbSci's $100 million readout was a single dose in 32 volunteers. The endpoint was side effects from one dose. It has not measured hair on a single person.

And with a half-life over 65 days, one shot blocks prolactin across your body for months. If it were a blockbuster hair drug, there could have been growth benefits by month 3.

So no, it is not a scam. The target is real.

But it is a monoclonal antibody, too large to cross skin so you have to inject it, for a condition a $20 generic already treats, riding on a placebo-controlled trial nobody will show you.

The prolactin pathway is real. The hype is the product.

[theriac @theriac33]

how to retain info better (using nootropics):

1. bromantane
2. bacopa monnieri
3. alpha gpc

here's why:

- bromantane doesn't just flood your brain with dopamine, it helps your brain PRODUCE and REGULATE it more efficiently over time.

this matters because if you want to retain info you brain needs to be fully engaged. it creates the tunnel vision effect.

- bacopa monnieri builds up gradually. it starts working after a few weeks of consistent use. people reported improved recall, clearer thinking, an less mental clutter.

it also helps with reducing anxiety which of course makes you more efficient.

- alpha gpc increases acetylcholine which is the main neurotransmitter responsible for learning and memory formation.

when these levels are higher, your brain processes information more efficiently and forms stronger memory connections.

these turn short term info into long term memory.

no matter what profession you're in, you can benefit from a better memory. you're not made to rely on 1000 todo apps.

improving memory is a net positive in any way you look at it. this is just the tip of the iceberg though

if you want a deeper look into the functions of these compounds and more, join the tg vault.

t33

[Real Peptides @realpeptides]

GLP-1s were originally created to help manage type 2 diabetes, but researchers have discovered they're able to kill cravings for alcohol, cocaine, opioids, and nicotine.

The evidence looks promising: (1/15)

[Healthy Alfred 🌴🥥 @HealthyAlfred]

Sermorelin significantly REDUCED body fat in a clinical trial.

not a diet drug. a peptide that was FDA-APPROVED — then pulled for being too cheap.

29 amino acids. tells your pituitary to make more GH.

in human studies:

→ DOUBLED GH secretion
→ IGF-1 up 35% in 6 months
→ lean mass — UP
→ cognition — IMPROVED
→ sleep — IMPROVED
→ body fat — DOWN (visceral hit hardest)

HGH costs $1,000+/month and overrides your system. Sermorelin costs a fraction and restores it.

one overrides. one restores.

your GH drops ~14% per decade after 30. by 60 — fumes. lighter sleep. slower recovery. easier fat storage.

that’s not aging. that’s a signal your pituitary stopped receiving.

Sermorelin sends it again.

🧵 how it works, how to take it, and what to stack it with below ↓

[Real Peptides @realpeptides]

The top compounds for cognitive excellence:

- Semax
- Nicotine
- Selank
- PE22-28
- NAD+
- Adamax
- Nazule

Still, after trying every one of these, nothing comes close to intranasal Semax.

[Michael Morelli @morellifit]

Semax is the closest thing to a limitless pill I've ever taken.

It has 40 years of safe Russian clinical use behind it. I've been using it for a few months and the cognitive benefits are insane.

Here's the breakdown: (1/16)

[James Hall @ItsJamesHall]

My wife is investing for the first time ever. Stocks & Shares ISA, £100/month, no prior experience.

What ETF would you put her all in on?

[Sonny @thehonestletter]

5 underrated UK side hustles you can start with under £100 of kit.

No social media following required. Real cash in your account within 2 weeks if you actually do them.

Save this thread.

[limitlesstack @limitlesstack]

one of the dumbest ways to think about drugs is assuming similar effects = similar risk.

i told a friend armodafinil gives me:

sustained wakefulness
no appetite
no fatigue
zero desire to sleep
an unreasonably good mood

"that sounds like meth."

subjectively? he's not completely wrong.

meth is basically the nuclear option:
- highly dopaminergic
- neurotoxic
- capable of wrecking lives, judgment and eventually the reward system itself

armodafinil is a very different animal:
- wakefulness-promoting rather than euphoric
- far less dopaminergic than classical stimulants
- not known for frying the brain
- zero overdose deaths on record
- literally used in military contexts where keeping people awake without turning them into unstable lunatics matters

this is why reducing drugs to "it feels like x" is such a bad way to think.

mechanism matters.
neurotoxicity matters.
addiction potential matters.
what happens after 3 days of use matters.
what happens after 3 months matters.

one is a wakefulness tool.

the other is a life destroying poison.

[The Biohacking Immortal @1Immortals1]

90% of people taking magnesium are taking the wrong form and wondering why they don't feel anything

magnesium citrate, oxide, glycinate: your body absorbs some of it but almost none crosses into the brain. you're basically expensive pissing it out

magnesium l-threonate is the only form clinically shown to cross the blood-brain barrier and increase brain magnesium levels

- developed at MIT specifically for cognitive function
- improves short term and long term memory in clinical trials
- reduces brain age markers by roughly 9 years in older adults
- enhances synaptic density - literally more connections between neurons
- eliminates the "tired but wired" feeling at night better than any other form
- calms the nervous system without making you drowsy during the day

the reason nobody talks about it is because it's more expensive than the other forms and supplement companies make better margins selling you oxide which has like 4% bioavailability

take 2g about an hour before bed. you'll notice the sleep difference in 3 days. the cognitive clarity takes about 2 weeks to kick in

magtein is the branded version. generic l-threonate works the same

[Dalton (Analyze & Optimize) @Outdoctrination]

Woman suffers from brutal fatigue, ruined her entire life. Low dose naltrexone brought her back to life.

"For me, low-dose naltrexone was truly life changing. From being virtually house bound, always limited by a multitude of symptoms, pain and low energy, I found my life returning.

Every treatment or therapy I had tried previously involved effort— pacing myself, training myself, coping with symptoms. With low-dose naltrexone, the improvement just happened— didn't have to try, I just got better."

LDN works by reducing inflammation via:

◇ TLR4 receptor antagonism
◇ Endorphin release augmentation