Dapeng Chen

[Dr Amol Akhade @SuyogCancer]

The NHS-Galleri trial reportedly failed its primary endpoint—a sobering reminder from @SullivanProf
and Dr Christopher Booth in this editorial at @JAMA_current
that technological elegance is no substitute for proven patient benefit. 🙂👇 @oncology_bg
https://t.co/SBy5n16VQf

[Science News @ScienceNews]

A portable device with $4 tuberculosis tests could be the answer to millions with limited access to health care.
https://t.co/jOZRggTmyj

[🔬 RicardoMontes @_MCRicardo_]

Whey Proteins & Immunity: Mechanisms Underlying Immune System Reinforcement & Protection Against Viral & Bacterial Infections

This review examines the immunological, anti-inflammatory, antiviral, & antibacterial activities of key whey & milk proteins, specifically lactoferrin, glycomacropeptide, β-lactoglobulin, α-lactalbumin & their derived peptides, particularly lactoferricin & lactoferrampin, highlighting their potential as preventive or therapeutic agents.

https://t.co/BzvOEx7NQr

Mechanisms underlying whey proteins (WPs)–mediated immune enhancement & infection resistance.

[Trends in Immunology @TrendsImmuno]

Scaling immunity: sickness as a host defense strategy https://t.co/tLapVvCKFv #immunology

[Eric Topol @EricTopol]

How digital twins and in silico clinical trials can change the future of drug development
https://t.co/lEhJNwrSlH

[JAMA @JAMA_current]

Among patients with #GramNegativeBacteremia, rapid #AntimicrobialSusceptibilityTesting did not improve 30-day clinical outcomes compared with standard testing, despite providing faster guidance for antibiotic escalation or deescalation.

#ESCMIDGlobal2026

https://t.co/Bq6fg9Ag94

[Medicina Interna HCSBA @MHcsba]

LANCET 2026: Seminar SEPSIS
https://t.co/ot5zFyfyWp
#MedEd #MedTwitter #MedX
https://t.co/cL7saZNryb

[ASM @ASMicrobiology]

The S. aureus V8 serine protease is a master manipulator of the immune response. But what does it target? Using a high-efficiency N-Terminomic approach, researchers capture ~320 biologically relevant V8 targets in the human lung proteome. #IAIJournal: https://t.co/xdhKuJ53PX

[The Lancet @TheLancet]

Sepsis is a serious condition where the body’s response to an infection becomes out of control and starts to damage its own organs.

A Seminar explores the complexity of the condition, and discusses current challenges and future developments in care: https://t.co/iWRfeRwgj1

[🔬 RicardoMontes @_MCRicardo_]

Presence of neutrophil extracellular traps (NETs) in different types of human urinary tract infections (UTI). A pilot study

▶️ Cystitis is the most common UTI in humans. This infection can ascend the urinary tract, spreading to the renal pelvis and potentially causing serious conditions such as pyelonephritis or urosepsis.

▶️ Human UTIs are primarily of bacterial origin, with E. coli being the most common urogenital pathogen.

▶️ A key defense mechanism of the innate immune system involves the formation of NETs that can trap and eliminate microbial agents.

▶️ Activated polymorphonuclear neutrophils (PMNs) release NETs, composed of a reticular DNA core, along w/nuclear histones, granular peptides, & enzymes.

▶️ Elevated levels of NETs, ​​exDNA, and related proteins, such as LL37 and MPO, were detected in urine samples from patients with UTIs & were associated w/leukocyturia.

▶️ Drugs such as furosemide, which affect the kidney's electrolyte balance & reduce NET formation, can exacerbate pyelonephritis.

▶️ The formation of the NETosis phenomenon is linked to the exacerbation of UTIs.

▶️ The presence of NETs in human urine confirms their role in the pathogenesis of urinary tract infections (UTIs).

▶️ Understanding these complex mechanisms could contribute to the development of targeted therapeutic strategies for patients with UTIs, although the polymicrobial nature of many complicated or recurrent UTIs poses a challenge.

https://t.co/HfFPGCtdR2 @HealthyFellow @tatiann69922625

Live-cell fluorescence microscopic (LCFM) analysis of human urine samples for the detection of bacterial colonization, leukocyturia, cellular activity and NET release

[ATS Red Journal @AJRCMB]

Pedal to the metal: iron regulation of Aspergillus fumigatus protease production
@atscommunity

🔓 Open Access

🔗 https://t.co/EkKlbrVjUV

[Dr. Thomas Ichim @exosome]

More and more papers showing neutrophils are diverse and can very closely manipulate adaptive immunity

here they show neutrophils
stimulating a B cell mediated autoimmune disease

https://t.co/7wfGMj6MAz

[nature @Nature]

Nature research paper: Natural maternal immunity protects neonates from Escherichia coli sepsis

https://t.co/apT1LTPORl

[Alí Sebastian Meza @AliSMV7]

Catheter-Associated Urinary Tract Infections Surveillance and Prevention

https://t.co/DCZqx3nYgD

[Ming "Tommy" Tang @tangming2005]

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment https://t.co/RC5rTrFO4l

[Cell Reports @CellReports]

Glutathione is critical for NK cell-mediated immunity https://t.co/l6JKnlQVTQ

[Matthias Mann Lab @labs_mann]

Now in @CellCellPress: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures.
https://t.co/MWxhWoooVC

[nature @Nature]

An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning

https://t.co/GnLOfSS6qj

[ERS publications @ERSpublications]

Leukocytic ADAM10 and ADAM17 and their release on exosomes modulate the local and systemic response upon bacterial and viral pneumonia and should be evaluated for diagnostic, prognostic and therapeutic options in future translational and clinical studies https://t.co/0kAOTpayII

[Cell @CellCellPress]

In the latest issue! Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment https://t.co/Sskpml4dAb