Las nuevas Guías Latinoamericanas de Pancreatitis Aguda (2026). Puntos importantes:
🟢 Cambio en el paradigma (gracias a WATERFALL Trial y otros): reanimación hídrica moderada a 1.5 ml/kg/h, con bolo SOLO en caso de haber hipovolemia franca.
🟢 No uses antibióticos profilácticos, solo en caso de necrosis pancreática infectada.
🟢 La CPRE es urgente (<24 horas) solo si hay colangitis aguda, sino no.
🟢 Menos es más; intenta diferir por lo menos 4 semanas la intervención de colecciones pancreáticas. Y si se necesita, idealmente endoscópico transluminal guiado por ultrasonido.
🟢 La hipertrigliceridemia es una causa (sobre todo si >500-1,000 mg/dL). El tratamiento: insulina en infusión.
Las voy a leer a fondo para actualizar las apps (https://t.co/FZoAsLTFc2).
En hemodiálisis, los β-bloqueadores no dializables (carvedilol, propanolol), comparado a los dializables (metoprolol, atenolol, bisoprolol); se asociaron a ↓~20% el riesgo de un evento cardiovascular mayor
En emulación de ensayo clínico
JASN 2026
10.1681/ASN.0000001147
🆕 Phase 3 SynAIRgy data shows Apnimed’s oral therapy AD109 reduced apnea-hypopnea index (AHI) by up to 55.6% on-treatment, with a massive 60.5% drop in hypoxic burden.
💤 Targeting neuromuscular dysfunction instead of just anatomy could offer a true pill for OSA 💊
Read more: https://t.co/cK8raaimkU
#Neurology #AHI #BrainHealth
🦠 🧫Bacteriemia por Gram (-) Multidrogorresistentes en el Paciente Inmunocomprometido
🔰📚Current Opinion
DOI:10.1097/QCO.0000000000001205
Enlace a Articulo Completo✅👇🏻🆓
https://t.co/rPEDXf5xvO
Ginseng Bioactive Components as Gut-Brain Axis-Targeted Modulators: Therapeutic Potential and Mechanisms in Multifactorial Diseases
▶️ Recent studies have indicated that the core biological activity of the substance under investigation is mediated by key active components such as ginsenosides, polysaccharides, & polyphenols.
▶️ These components are closely associated w/the regulation of the gut-brain axis (GBA).
✅️ It has been demonstrated that ginseng components exert a multifaceted GBA regulatory effect through interconnected mechanisms, including modulation of the gut microbiota, protection of the intestinal barrier, anti-inflammatory actions, & regulation of neurotransmitters, showing promising preclinical therapeutic potential in neurodegenerative diseases, mood disorders, metabolic diseases, & gastrointestinal disorders.
https://t.co/UjOOONDX6R @HealthyFellow
🔹 Webinars SEMI
“Manejo multidisciplinar de los pacientes con uveítis”
SESIÓN ONLINE - SEMI / FEMI
WEBINARS GRUPO GEAS
📅 Jueves, 11 de junio de 2026
🕓 16:00 – 17:30 h
La inscripción es gratuita y puede formalizarse cumplimentando formulario de inscripción.
👉 https://t.co/f03Zmy8nO2
MODERADOR
Gerard Espinosa
Consultor Senior. Servicio de Enfermedades Autoinmunes. Hospital Clínic, Barcelona
PAPEL DEL OFTALMÓLOGO
Alejandro Fonollosa Calduch
Servicio de Oftalmología. Hospital Universiario Cruces
Instituto de Investigación Biobizkaia
Universidad del País Vasco
Departamento de Retina. Instituto Oftalmológico Bilbao.
PAPEL DEL INTERNISTA
Ioana Riuz Arruza
Unidad de Investigación de Enfermedades Autoinmunes
CSUR de Enfermedades Autoinmunes Sistemáticas
Servicio de Medicina Interna. Hospital Universitario Cruces
Instituto de Investigación Biobizkaia
Universidad del País Vasco
#SEMI #MedicinaInterna #internista
Leishmaniases comprise clinically distinct diseases caused by the protozoan parasite leishmania, which is transmitted through the bite of infected sand flies (Panel A). Leishmania are obligate intracellular parasites that invade and multiply within host phagocytes. CD4+ T cells are critical for host defense, since they produce interferon-γ, a key cytokine that activates macrophages to kill parasites. Most leishmania species that cause human disease also infect domestic and wild animals, such as dogs, cats, hyraxes, sloths, and rodents, which serve as zoonotic reservoirs. Infected sand flies are responsible for most cases of transmission, but visceral leishmaniasis (also known as kala-azar) can also occur through blood transfusion, organ transplantation, congenital transmission, needle-stick injuries, or sharing of contaminated syringes.
Leishmaniasis is endemic in Africa, the Americas, Asia, and Europe (Panels B and C). More than 1 billion people in 99 territories and countries where leishmaniasis is endemic, including the United States, are at risk for contracting the disease. The global prevalence of leishmaniasis is estimated to be 6 million cases, and approximately 0.7 to 1 million new cases occur annually. Most cases occur in people in endemic countries in Africa, Asia, and Latin America where inadequate evening shelter and limited personal protective measures result in continuous vector exposure. Other factors contributing to the high prevalence of leishmaniasis include malnutrition, lack of disease awareness, coinfections with HIV and helminths, and forced population displacement due to conflicts. Leishmaniasis is also endemic in the Middle East, southern Europe, and the Americas, where immunosuppression and travel are additional risk factors.
Read the Review Article “Leishmaniasis” by Naomi E. Aronson, MD, Ahmed M. Musa, MB, BS, DTMH, PhD, and Abhay R. Satoskar, MB, BS, MD, PhD (@SatoskarAbhay, from Uniformed Services University (@USUhealthsci), the University of Khartoum (@u_of_k), and @ohiostate: https://t.co/N3LaviIpzU
Seguimos clasificando la insuficiencia cardíaca aguda descompensada con esquemas que apenas han cambiado en quince años, y eso puede estar lastrando los ensayos clínicos.
https://t.co/dUVoo826Bm
🔄 TACCITT integra desencadenantes, etiología, comorbilidades, fenotipo y trayectoria.
📊 Cuatro trayectorias intrahospitalarias predicen el pronóstico.
🩺 La IC avanzada no es el destino de la mayoría de los pacientes.
👉 Lee el análisis completo en CardioTeca.
Intensive care medicine (ICM) 2023: 10 Consejos para manera pancreatitis aguda severa en unidad de paciente crítico
https://t.co/D6EeRGTpiY
#MedEd#MedTwitter#MedX
Spectrum of glomerular diseases: It is a simplification to group conditions as either proteinuric or hematuric (nephrosis vs nephritis) because many diseases present with features of both, and a late consequence of “hematuric” damage to the glomerulus is proteinuria. The position on the spectrum illustrates the typical situation at the time of diagnosis.
#Nephpearls #ECNeph
Illustration by @neilturn
https://t.co/g7wdNBQHNC
#Hypogonadism in adult men is characterized by signs and symptoms of #testosterone deficiency with consistently low morning serum testosterone concentrations.
🔗 Learn more about the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of male hypogonadism in this JAMA Review: https://t.co/lGamwsczmd
Normal CRP ≠ No Inflammation.
Active disease may occur with a normal CRP in:
🔹 SLE (especially lupus nephritis)
🔹 Sjögren disease
🔹 Inflammatory myopathies
🔹 Systemic sclerosis
🔹 Some ANCA-associated vasculitis
Also remember:
💊 IL-6 inhibitors, steroids & JAK inhibitors can suppress CRP
🦠 Early/localized infections may have a normal CRP
Treat the patient, not the number.
#Rheumatology #CRP #Lupus #Vasculitis #Myositis @docakx@IhabFathiSulima #MedTwitter #FOAMed
📌 GRAVES DISEASE vs HYPOTHYROIDISM
A high-yield comparison every medical student & doctor should know.
⚡ Hyperthyroid vs Hypothyroid
👁️ Exophthalmos vs Puffy face
🔥 Heat intolerance vs Cold intolerance
💓 Tachycardia vs Bradycardia
📉 Low TSH vs 📈 High TSH
From physiology ➝ pathology ➝ diagnosis ➝ treatment — all in one infographic.
#MedTwitter #FOAMed #Medicine #MedEd #MedicalEducation #Endocrinology #Thyroid #GravesDisease #Hypothyroidism #USMLE #PLAB #NEETPG #MRCP #Doctors #MedStudent
🚨 LA ENFERMEDAD RENAL CRÓNICA (ERC) ya no debe diagnosticarse tarde. Un artículo reciente en Nephrology Dialysis Transplantation 2026 propone cambiar el paradigma: pasar de “tratar diálisis” a “PREVENIR ERC” 🩺🧠. El mensaje es contundente: una creatinina normal NO descarta daño renal ❌🧪, porque muchos pacientes ya tienen albuminuria elevada con TFG conservada 📉. La clave está en el enfoque ABCDE 🔍: A️⃣ Albuminuria, B️⃣ Presión arterial, C️⃣ Colesterol, D️⃣ Diabetes y E️⃣ eGFR. El gran problema actual es que la albuminuria sigue infrautilizada 📋, pese a que detectarla temprano permite iniciar nefroprotección con iSGLT2, IECA/ARA2, finerenona y agonistas GLP-1 💊❤️🩺, logrando retrasar diálisis incluso hasta 20–30 años ⏳. Además, esta revisión introduce un concepto revolucionario: “PRE-CKD” ⚠️, pacientes aún sin ERC formal pero con alto riesgo de desarrollarla, igual que ocurre con la prediabetes. El futuro de la nefrología será prevención, detección temprana y protección cardio-reno-metabólica 🌎🫀🧬. Pedir UACR anual en pacientes con HTA, DM2, obesidad o >60 años puede cambiar vidas. #CKD #ERC #Nefrología #Albuminuria #SGLT2 #Finerenona #PrevenciónRenal #CardioRenalMetabólico #KDIGO #MedicinaInterna
📚 Nephrol Dial Transplant. 2026;41:418–427. doi:10.1093/ndt/gfaf151.