Chiosis Lab

🔬🖥️🐭🇺🇸
The Gabriela Chiosis Lab in the Chemical Biology Program @MSKCancerCenter

[Chiosis Lab @chiosislabmskcc]

🚨Publication alert! The final version of our article is OUT NOW in @TrendsBiochem.
@ChiosisLabmskcc is honored to have been selected as the cover feature for this issue - cover art by a VI4 Artist in Residence.
Check out the review article here:
https://t.co/Yf9GzchU8P

[Chiosis Lab @chiosislabmskcc]

⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem
#PTMs #HSP90 #epichaperome #PPI #neuroscience
https://t.co/pszZWjRGLb

[Chiosis Lab @chiosislabmskcc]

Last Friday @phdsadikbay presented some of our latest research at the 22nd Anderson Cancer Symposium. More to come!
#interactome #mitochondria #HSP90 #proteomics #heatshockprotein #PTMs #posttranslationalmodification #cancer #omics

[Biomedicines MDPI @Biomed_MDPI]

🖼 Graphical Abstract | Explore the key findings through graphics
📌 Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders
🔗 https://t.co/daYZDtcWqn
#VisualResearch

[Chiosis Lab @chiosislabmskcc]

🌅 Another busy summer in the books! Chiosis Lab mentored 9 high school & undergraduate students over the last few months. We are always happy & inspired to support young people interested in science.
Shoutout to our excellent students & kudos to their mentors! #STEM #mentorship

[Chiosis Lab @chiosislabmskcc]

🧑‍🔬Congratulations to the team that worked on Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation–driven model, now published in the Journal of Clinical Investigation @jclinicalinvest.
Read it here: https://t.co/Cch4r6utEK

[Zhi Yu @ZhiYu_ACGT]

🎉Excited to share our new paper in @jclinicalinvest, co-led by the Kapur lab and @LinkeLi_MGH, and co-senior with @santhu_131!

How does obesity accelerate PTPN11-driven myeloid leukemia - and can we intervene?

🧬 In human, obesity traits tracked with elevated plasma IL-17A, reduced GLP-1R, and heightened myeloid leukemia risk.
🐁 In mice, obesity accelerated leukemogenesis via Th17/IL-17A & M2 TAMs, and dual anti–IL-17A + GLP-1R agonist 💊 reverse it.

Together, we demonstrated a tractable strategy for high-risk obese patients with PTPN11 mutations: https://t.co/2Lmp8sPV1z

[Chiosis Lab @chiosislabmskcc]

#bioinformatics #proteomics #dfPPI #systemsbiology #interactome #interactomics #massspec #neuroscience #cancerbiology #cancer #massspectrometry

[Chiosis Lab @chiosislabmskcc]

@souparna_c presents the dfPPI Analysis Platform—a browser-based workflow for turning interaction-capture mass-spectrometry data into differential interaction-engagement models, pathway-rewiring maps and network-level results.
Read more in @SpringerNature https://t.co/90QRkPehdO

[Chiosis Lab @chiosislabmskcc]

Check out Chiranjeevi's @SpringerNature blog on Structural & Dynamic Basis of Phosphorylation-Mediated HSP90 Conformational Switching Controls Epichaperome Assembly & Cellular Proliferation, recently presented as a poster at The 2nd NextGen Conversations https://t.co/1fQSvSPApo

[Chiosis Lab @chiosislabmskcc]

Last week, Chiranjeevi and Souparna presented posters at the Next Gen Conversations on Biomolecular Structure and Dynamics at Louisiana Tech. #HSP90 #Epichaperome #dfPPI #proteininteractions #proteomics #chemoproteomics

[Chiosis Lab @chiosislabmskcc]

🥼In-cell mapping of epichaperome higher-order assemblies by chemical-probe enrichment and crosslinking mass spectrometry at #ASMS2026 presented by Shujuan Wang!
@asmsnews #epichaperomics #omics #massspectrometry #CellStress

[Am Soc for Mass Spec @asmsnews]

@chiosislabmskcc We love seeing passionate researchers representing their labs and sharing their work with the ASMS community. Great job, Shujuan and Luke!

[Chiosis Lab @chiosislabmskcc]

'Complex-resolved epichaperomics reveals PTM-coded rewiring of HSP90–HSC70–cochaperone scaffolds across cellular states' presented by Luke Botticelli on Saturday at #ASMS2026! 🤓Thank you to everyone engaged with our work!
@asmsnews #epichaperome #proteomics #massspectrometry

[Chiosis Lab @chiosislabmskcc]

Shoutout to Shujuan and Luke for representing Chiosis Lab at #ASMS2026!

#TeamMassSpec #XLMS #chaperomics #MassSpec #MassSpectrometry #epichaperome #epichaperomics #proteincomplexes #PTM #omics #proteiomics @asmsnews

[Chiosis Lab @chiosislabmskcc]

#ASMS2026, today is the day! Be sure to stop by Shujuan and Luke's posters during today's session.
@asmsnews #LCMS #XLMS #epichaperomics #proteincomplexes #crosslinking

[Chiosis Lab @chiosislabmskcc]

#ASMS2026 folks, don't miss these poster presentations tomorrow!

#XLMS #LCMS #epichaperome #chaperomics #proteincomplexes
@asmsnews #TeamMassSpec

[Chiosis Lab @chiosislabmskcc]

📢Attention #ASMS2026 attendees! Don't miss poster presentations by Shujuan and Luke on Wednesday June 3rd
#epichaperome #XLMS #crosslinking #LCMS #chaperomics #epichaperomics
@asmsnews #TeamMassSpec

[Chiosis Lab @chiosislabmskcc]

📹OUT NOW! We present a protocol to enable the capture & identification of disease-specific protein-protein interactions from native cells & tissues using chemical probes & mass spectrometry https://t.co/UyxOi4rEtK #Proteomics #interactome #omics #dfPPI #SciComm @JoVEJournal

[Chiosis Lab @chiosislabmskcc]

🩺 🎉 Thrilled to share our intern Jeremy has committed to @TCNJ @Rutgers_NJMS 7-year BS/MD Medical Program. Congratulations, Jeremy! Kudos to @digwal_chander and @Chiranjeev95533 for superb mentorship & guidance. #STEM #ResearchTraining #Mentorship #FutureScientist #FutureMD

[Gabriela Chiosis @GabrielaChiosis]

Congrats to Ranveer Kamboj on winning 1st place (Health & Medicine) at the NJ Academy of Science Research Symposium for his summer research in the @chiosislabmskcc under the mentorship of @SsGq2009. Excellent work & great to see it recognized 👏🔬 #STEM #NJAS2026 #ResearchImpact

[Chiosis Lab @chiosislabmskcc]

In @JoVEJournal we present #dfPPI, a protocol to enable the capture & identification of disease-specific protein-protein interactions from native samples. #neuroscience #interactome #proteome #epichaperome #scicomms #MassSpectrometry #SystemsBiology #omics
https://t.co/VUI9TaQdpO

[Gabriela Chiosis @GabrielaChiosis]

Most omics measure abundance. Disease rewires interactions.

Our @JoVEJournal protocol describes dfPPI, an endogenous, systems-level method to capture dysfunctional PPI networks directly in native samples. https://t.co/0s85Z1Q6ap
#ProteinInteractions #SystemsBiology #Proteomics

[Chiosis Lab @chiosislabmskcc]

Check out our cover article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' in @TrendsBiochem?
#scicomms #sciencecommunication #HSP90 #epichaperome #neuroscience #proteome #interactome #omics https://t.co/mWxv4Hvg2G

[Chiosis Lab @chiosislabmskcc]

🚨Publication alert! The final version of our article is OUT NOW in @TrendsBiochem.
@ChiosisLabmskcc is honored to have been selected as the cover feature for this issue - cover art by a VI4 Artist in Residence.
Check out the review article here:
https://t.co/Yf9GzchU8P