Malcolm Choo

Senior Scientist Trainee at Abbvie. Fascinated about complex natural products and their bioactivities. Currently obsessed about molecular glues!

[Stuart Schreiber @SchreiberStuart]

Proximity-inducing #molecularglues for RAS- and RAF-dependent cancers

[Mayowa Tijani @OluwamayowaTJ]

The most annoying part of academic writing is knowing the thing, but looking for some other paper to say it for you. You can't just say bread is soft, you have to say according to Baker 2001, bread is soft. 😕

[Malcolm Choo @ChooMalcolm]

Grateful to be able to attend the 15th HOPE meeting in Kyoto, Japan this year! This is me, giving my Nobel lecture 🤣
#JSPS #HOPEMEETING

[Malcolm Choo @ChooMalcolm]

I need to start doing this.

[That Chemist @That_Chemist]

Something you may not know about Barry Sharpless

[Retraction Watch @RetractionWatch]

"If you’re trying to get into Nature, 'humility is punished, or strongly discouraged.'" On celebrity in science.
https://t.co/lpwVHLZhCi

[Alessio Ciulli @alessiociulli]

We've updated our DCAF16-BRD4 preprint with lot new data: structure-design picomolar degraders, glues to a distinct E3 ligase (DCAF11) and revised title: Targeted protein degradation via intramolecular bivalent glues @UoDCeTPD @ollie_lh @georg_e_winter https://t.co/2aLqLNkmfj

[Royal Society of Chemistry @RoySocChem]

Celebrate the game-changers, visionaries, and trailblazers in the chemical sciences in our special hour-long webinar taking a deep dive into this year’s #NobelPrize winning science.

Secure your place for this @ChemistryWorld webinar today: https://t.co/7UTFRu5y6Y

[ChemMedChem @ChemMedChem]

#ClickChemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? (M. L. Bolognesi et al.) @mlbolognesi #openaccess https://t.co/LkEYsSPxkh

[Malcolm Choo @ChooMalcolm]

So stoked to receive this book on targeted protein degradation from @culturedscience ! Thanks for the wonderful gesture!
#EFMCASMC23

[Malcolm Choo @ChooMalcolm]

By far, the most captivating talk about dreams and ideal reactions in this year's #EFMCASMC23 conference by Prof Nuno Maulide!

[Elisabeth Bik @MicrobiomDigest]

Feedback from the journal:
"the Journal of Virology and American Society for Microbiology (ASM) could not substantiate these figure concerns."
You got to be kidding me.
#ImageForensics @JVirology @ASMicrobiology

[Stuart Schreiber @SchreiberStuart]

X-ray structure determinations illuminate the striking ability of creative DELs and DEL screens to yield novel binders – in this case MPro inhibitors from @DamianYoung29 and collaborators.

[Shaheryar Shafi @ShaheryarShafi_]

What does Ph.D. stand for? Here are some hilarious answers from fellow grad students! #PhDHumor #PhDChat #PhDLife #AcademicChatter #ResearchTips #AcademicSuccess #researchtips #epitwitter #MedTwitter #phchat #acwri

[Covalent Modifiers @CovalentMod]

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation https://t.co/gEBPuMmzaC

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

I just refused to review an article for the journal Structure with this message.

[Darryl B McConnell @D_B_McConnell]

What we are trying to do with PROTACs and proximity drugs clearly goes against the grain with respect to molecular weight (MW) but not as much as you might think.
The mean MW of current oral clinical PROTACs is 785 Da versus 370 Da for all approved oral drugs.

[Alessio Ciulli @alessiociulli]

Excited to share our new review on Proximity-Based Modalities for Biology and Medicine | Just out ASAP in ACS Central Science @ACSCentSci https://t.co/bkDdnQS2TM

[Ingo Hartung @HartungIngo]

Very pleased to see Derek Lowe discussing our very recent paper on quality criteria for covalently acting & molecular degrader chemical probes: Chemical Probes, Used and Misused | Science | AAAS ⁦@thesgconline⁩ #openscience https://t.co/3WdpxhJYVJ

[Covalent Modifiers @CovalentMod]

Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines https://t.co/n2KdCiPXW9

[Covalent Modifiers @CovalentMod]

Comprehensive Mapping of Electrophilic Small Molecule-Protein Interactions in Human Cells https://t.co/SEjZZbClXI