Chun-Yen Lin

Postdoc Fellow at Pentelute group, MIT. Chemistry Ph.D. at Prof. Ken-Tsung Wong’s group, NTU. Being obsessed with chemistry, coffee, and rock music.

[Nature Chemical Biology @nchembio]

A ratiometric fluorescent reporter of mitochondrial sodium reveals striking heterogeneity in mitochondrial Na+, its dynamic coupling to Ca2+ influx, and its alteration in metabolic stress and mitochondrial disease

https://t.co/3KbLqsRPvr

[Nature Chemical Biology @nchembio]

A new paper presents CANVAS, a computational workflow that converts minimal de novo TIM barrels into enzymes by designing structural lids that generate tailored active sites

https://t.co/RDHDe2gtkc

[Ah-Ram Kim @ahramkim1128]

Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes

"Here, we present CANVAS, a computational workflow that introduces a structural lid into a minimal de novo TIM barrel to anchor catalytic residues and form an active site."

https://t.co/dHynownxNL

[Ah-Ram Kim @ahramkim1128]

Charged molecular glue discovery enabled by targeted degron display https://t.co/iIvBba5jML

[nature @Nature]

Nature research paper: Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

https://t.co/l5O4DWaZrp

[Ah-Ram Kim @ahramkim1128]

High-throughput ligand diversification to discover chemical inducers of proximity https://t.co/kO03flSSOG

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in the design of next-generation small-molecule kinase inhibitors, here's a comprehensive review https://t.co/1NZlTPiwBR
https://t.co/53pEaaub7u

[Nature Chemical Biology @nchembio]

Generation of membrane-permeable cyclic peptides inhibiting protein-protein interaction

https://t.co/yFPApF9p8S

[Guillaume Laconde @Glaconde34]

A Rapid Binder Discovery Workflow for Engineering Mini-Protein Degraders | Journal of the American Chemical Society https://t.co/tbLBhl0cf9

[J. Am. Chem. Soc. @J_A_C_S]

Direct Quantum Yield Measurement of a Ligand-to-Metal Charge Transfer Photocatalyst via Cyclic Voltammetry | Journal of the American Chemical Society https://t.co/fb4GDiU2NZ

[J. Am. Chem. Soc. @J_A_C_S]

Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision | Journal of the American Chemical Society https://t.co/S8Ms6QQw3r

[Dr Rishabh Jain @DrRishabhOnco]

🧬 KRAS is no longer “undruggable”.
A new Cancer Cell review maps how KRAS inhibitors are reshaping therapy across lung, colorectal, pancreatic and other cancers, and what comes next.

🔬 Essentials
• RAS alterations drive ~20% of cancers worldwide
• KRAS is the most frequent RAS alteration
• KRAS G12C inhibitors proved direct RAS targeting works

💊 Current reality
🟢 Sotorasib & adagrasib show meaningful activity in KRAS G12C NSCLC
🟢 CRC responses improve when combined with anti-EGFR therapy
🟢 Activity emerging in PDAC and other tumors

⚠️ Key challenge
Most patients eventually develop resistance via:
• On-target KRAS mutations
• MAPK pathway reactivation
• RTK feedback signaling
• Non-genetic adaptive escape

🚀 What’s next?
Next-generation strategies include:
• More potent G12C inhibitors
• KRAS G12D & multi-mutation inhibitors
• Isoform-selective and pan-RAS inhibitors
• Rational combination approaches

Takeaway: KRAS targeting has moved from breakthrough to optimization phase, with broader RAS inhibition now the next frontier.

📖 Full paper in comment ⬇️
#OncoTwitter #MedTwitter #LungCancer #CRC @OncoAlert @myesmo @esmo_open @ASC

[Chemistry News @ChemistryNews]

Amino-acid-encoded assembly of programmable chiral Solomon links https://t.co/hR2FGTaD6X

[Guillaume Laconde @Glaconde34]

Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy | Journal of the American Chemical Society https://t.co/FLbRe77OO7

[Guillaume Laconde @Glaconde34]

Direct-to-Biology Enabled Molecular Glue Discovery | Journal of the American Chemical Society https://t.co/eDjS844RVP

[J. Am. Chem. Soc. @J_A_C_S]

Precision Labeling of Native Antibodies with Lock Coupling | Journal of the American Chemical Society @UCBerkeley @BerkeleyLab https://t.co/m1gZgXy5dy

[Nature Biotechnology @NatureBiotech]

Biomacromolecules are delivered across the blood–brain barrier when administered systemically https://t.co/pzZYd4fSUw
https://t.co/v6TDCa8KqN

[Nature Reviews Chemistry @NatRevChem]

Protein mapping at the speed of light https://t.co/PQiu3zHFYP 🧪

[Chemistry News @ChemistryNews]

Weaving-inspired asymmetric entangled nodes in multi-component polymer networks https://t.co/nBkEMknsst

[Nature Biotechnology @NatureBiotech]

Specific binders to peptide–MHC class II are rapidly generated without laborious screening https://t.co/V7N6AGYPtV
https://t.co/UwDJy4S8Sh