Clara Taffoni

Post-doctorant in the "Molecular basis of Inflammation" lab, @IGMM_Montpel.
Cancer and infection-related immune response.

[Journal of Experimental Medicine @JExpMed]

Vila, Messaoud-Nacer, Taffoni, Laguette et al show that DNA-PKcs, a major DNA damage response actor, interacts w/ cyclic dinucleotides through its kinase domain, ensuring CDN-associated signal termination, while CDNs inhibit DNA-PKcs catalytic activity https://t.co/KBMo7fi7Mj

[Clara Taffoni @ClaraTaffoni]

Many thanks to all @LabLaguette members and collaborators who contributed to this work!! #DNA-PKcs #2’3’-cGAMP #STING

[Laguette Nadine @LaguetteNadine]

Fresh off the press!👀
Check out our newest work where we show that DNA-PKcs directly binds 2'3' and 3'3'-cGAMP, regulating their bioavailability and STING-dependent signaling! DNA-PK controls cyclic dinucleotide-associated type I Interferon responses https://t.co/kKAE5PaGLa

[Laguette Nadine @LaguetteNadine]

Fresh off the press!👀
Check out our newest work where we show that DNA-PKcs directly binds 2'3' and 3'3'-cGAMP, regulating their bioavailability and STING-dependent signaling! DNA-PK controls cyclic dinucleotide-associated type I Interferon responses https://t.co/kKAE5PaGLa

[Clara Taffoni @ClaraTaffoni]

@umontpellier thank you very much for this award! And thanks to @LaguetteNadine, @LabLaguette and our collaborators! It would have never been possible without your support!!

[Isabelle K Vila @IsabelleKVila1]

Congratulations to our @ClaraTaffoni on receiving the young scientist award from the @umontpellier ! @LabLaguette @LaguetteNadine @IGMM_Montpel @IGH_MTP

[Karim Majzoub @KarimMajzoub]

Excited to share the first study from our young lab led by Pierre Khalfi (Post-doc) and Zoé Denis (PhD student)-> a brief Twittorial-->

Unraveling human, rodent and snake Kolmioviridae replication to anticipate cross-species transmission https://t.co/0lxRtVoW9S

[ConstantinouLab @ConstantinouL]

Our teamwork by @EmileELGhouL, @BasbousJihane, in collaboration with Alessandro Barducci, Matteo Paloni @betterwithchem, and Pierre Henri-Gaillard @gaillardphl is now online @MolecularCell. https://t.co/WhaeWgSQ0w

[Clara Taffoni @ClaraTaffoni]

So proud of our work on the cover of the @embojournal!!! Thanks again to @LabLaguette, our collaborators and @skrahl!!

[The EMBO Journal @embojournal]

Issue 7 starts our 2023 RNA Review Series
Mitostores allow precursors to ride out the storm
Catch bonds & T-cell antigen recognition
Macromolecular crowding in the mitochondrial matrix
Cover: @ClaraTaffoni @JohannaMarines1 @LaguetteNadine et al by @skrahl
https://t.co/SVwglHMVHi

[Clara Taffoni @ClaraTaffoni]

What a wonderful news to end the year! Thanks to all collaborators! @nbidere @ Julie Gavard @c_maghe @JaneJardine6 @ Mi Kyung Park @maraademartino @CVanpouilleBox @ M. del Rio @NativelCeline @ Min Sup Song @DonovanPineau @ J-P. Hugnot @KarimaKissa
@ L. Fontenille @ F.P. Blanchet

[Laguette Nadine @LaguetteNadine]

Nice way to end 2022! Congrats @ClaraTaffoni, @JohannaMarines1
and our many co-authors! DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma https://t.co/VrFqlewNQn

[Laguette Nadine @LaguetteNadine]

Welcome to the @IGH_MTP ! The @LabLaguette wishes you a merry Holidays season! @IsabelleKVila1 @ClaraTaffoni @MoritzSchussler @AceGuha @chastel_tommy @batman(Robin)

[Charlene Boumendil, she/her @CharleneBoumen1]

The lab is growing! Three positions available: postdoc and research assistant (master or PhD level) starting in January, lab manager/technician starting in March. More details below! #newPI

[Laguette Nadine @LaguetteNadine]

Happy to share this moment with @ClaraTaffoni. It would have been amazin to have all the team with us @LabLaguette @IGH_MTP !

[Laguette Lab @LabLaguette]

We are currently recruiting a post doctoral fellow (for September 2022. If you have expertise in biochemistry, molecular biology and an interest for the study of innate immune responses - consider applying. To apply, visit the CNRS website (or email me!). RT! @IGH_MTP

[Laguette Lab @LabLaguette]

DNA-PK catalytic activity enables cGAS-dependent cGAMP production. Beautiful collabroative work, led by @ClaraTaffoni and @JohannaMarines1 Check it out: The crosstalk between DNA-PK and cGAS drives tumor immunogenicity https://t.co/PvTbD8tPNS

[Clara Taffoni @ClaraTaffoni]

thanks also to @ChammaHanane @IsabelleKVila1 @AceGuha

[Laguette Nadine @LaguetteNadine]

And last, but not least, thanks to all @LabLaguette members, and especially @ClaraTaffoni and @JohannaMarines1 ! You rock!

[Laguette Nadine @LaguetteNadine]

Beyond thrilled that our super talented @IsabelleKVila1 secured a permanent @CNRS researcher position ! Looking forward to some amazing science ahead @LabLaguette ! Congratulations again on a much deserved success!

[Clara Taffoni @ClaraTaffoni]

The crosstalk between DNA-PK and cGAS drives tumor immunogenicity https://t.co/6TsZJ3B9g1 Super happy to share with you our new work on how the cooperation between DNA-PK and cGAS shapes tumor immunogenicity!!! It was a pleasure to work with you @JohannaMarines1

[Laguette Nadine @LaguetteNadine]

Best way to start 2022! Our manuscript, uncovering the role of STING in PUFA metabolism is now out @Cell_Metabolism !

[Cell Metabolism @Cell_Metabolism]

NEW ISSUE!: Featuring work from Vila et al. discovering that STING regulates polyunsaturated fatty acid (PUFA) metabolism, and in turn, PUFAs inhibit STING-dependent inflammation.
https://t.co/d6exB5BDGd

[Laguette Lab @LabLaguette]

#PhD positions available in #Montpellier ! Join us!