Clerget Françoise

généticienne, biostatisticienne

[Clerget Françoise @Clergetdarpoux]

@Courtsmithrun Another reason is that those who have worked on the involvement of HLA genes in numerous diseases know that association information alone does not allow for modeling their interactive effects in pathological processes.
https://t.co/U5QfsY09Ds

[Clerget Françoise @Clergetdarpoux]

@SashaGusevPosts As far as I'm concerned, I am even more surprised that we continue to talk about Twin Heritability and SNP Heritability.

[Clerget Françoise @Clergetdarpoux]

@HeyerEvelyne ... effrayant !

[Heyer Evelyne @HeyerEvelyne]

Incroyable! https://t.co/Rwb5LBctLB

[Clerget Françoise @Clergetdarpoux]

@joe_pickrell What a pity!!!
I was just planning to calculate my polygenic score to see if I was meant to be a dog owner.🤣

[Clerget Françoise @Clergetdarpoux]

@SashaGusevPosts "And yes... This paper (which is 12 years old) was already warning about the absurdity of estimating heritability under incorrect assumptions.

[Clerget Françoise @Clergetdarpoux]

@GenomicsVC @Omar_MalinGenie @krichard1212 @SashaGusevPosts @NatureGenet Khera's collaborators continue to believe in it ... despite the contrary arguments illustrated ontheir data.😉
https://t.co/GO3wk2WQie

[Clerget Françoise @Clergetdarpoux]

Even though it took 17 years, it's comforting to see the truth about 23andMe's false promises come to light. The drop in its stock value might have more impact than scientific arguments (some of which are, by the way, well understood by the journalist Kristen Brown)

[Clerget Françoise @Clergetdarpoux]

At last...
https://t.co/lbigs2wxqx

[Clerget Françoise @Clergetdarpoux]

@GenomicsVC @Omar_MalinGenie @krichard1212 @SashaGusevPosts @NatureGenet https://t.co/kYnVhab7aa
Of course, treatments must also take into account the heterogeneity of pathogenic processes.

[Clerget Françoise @Clergetdarpoux]

@GenomicsVC @Omar_MalinGenie @krichard1212 @SashaGusevPosts @NatureGenet Polygenic risk scores, like heritability, don't apply to heterogeneous diseases (i.e., all complex diseases). Falconer explained this in 1967, yet most physicians prefer to use software that provides them with simple rules rather than understand where the problem lies.

[Clerget Françoise @Clergetdarpoux]

@jayjoseph22 After years of working on autoimmune diseases and their associations with genetic markers, I find it disconcerting to see the simplistic interpretations of GWAS and the notion that it allows the extraction of genetic variance (SNPh)🙄
What a terrible drift in human genetics!

[Clerget Françoise @Clergetdarpoux]

@jayjoseph22 Everyone thinks they're doing genetics by applying Falconer's formula to estimate heritability. This formula is so simple!
However, Falconer emphasized as early as 1967 that it did not apply to etiologically heterogeneous diseases (thus ultimately to any human disease).

[Clerget Françoise @Clergetdarpoux]

@SashaGusevPosts What a wise resolution...And yet, should we not continue to protest against those who speak of the heritability or PRS for IQ by making assumptions that make no sense?

[Clerget Françoise @Clergetdarpoux]

@FranckRamus @LEXPRESS @sup_recherche @Sante_Gouv @sretailleau @Etienne_Pot Celle-là, c'est la première fois que je l'entends🤣

[Clerget Françoise @Clergetdarpoux]

@FranckRamus @LEXPRESS @sup_recherche @Sante_Gouv @sretailleau @Etienne_Pot C’est super que vous vous battiez pour que l’éducation nationale reconnaisse certains handicaps à l’apprentissage scolaire et mette en place des dépistages précoces de problèmes cognitifs ... mais sans pour autant faire dire n’importe quoi à la génétique statistique!

[Clerget Françoise @Clergetdarpoux]

@FranckRamus @LEXPRESS @sup_recherche @Sante_Gouv @sretailleau @Etienne_Pot Ça ne préjuge en rien des mécanismes sous-jacents.
- En effet ...alors que beaucoup l’interprètentcomme une mesure du poids de la génétique !🙄