@Courtsmithrun Another reason is that those who have worked on the involvement of HLA genes in numerous diseases know that association information alone does not allow for modeling their interactive effects in pathological processes.
https://t.co/U5QfsY09Ds
@SashaGusevPosts "And yes... This paper (which is 12 years old) was already warning about the absurdity of estimating heritability under incorrect assumptions.
@GenomicsVC @Omar_MalinGenie @krichard1212@SashaGusevPosts@NatureGenet Khera's collaborators continue to believe in it ... despite the contrary arguments illustrated ontheir data.😉
https://t.co/GO3wk2WQie
Even though it took 17 years, it's comforting to see the truth about 23andMe's false promises come to light. The drop in its stock value might have more impact than scientific arguments (some of which are, by the way, well understood by the journalist Kristen Brown)
@GenomicsVC @Omar_MalinGenie @krichard1212@SashaGusevPosts@NatureGenet https://t.co/kYnVhab7aa
Of course, treatments must also take into account the heterogeneity of pathogenic processes.
@GenomicsVC @Omar_MalinGenie @krichard1212@SashaGusevPosts@NatureGenet Polygenic risk scores, like heritability, don't apply to heterogeneous diseases (i.e., all complex diseases). Falconer explained this in 1967, yet most physicians prefer to use software that provides them with simple rules rather than understand where the problem lies.
@jayjoseph22 After years of working on autoimmune diseases and their associations with genetic markers, I find it disconcerting to see the simplistic interpretations of GWAS and the notion that it allows the extraction of genetic variance (SNPh)🙄
What a terrible drift in human genetics!
@jayjoseph22 Everyone thinks they're doing genetics by applying Falconer's formula to estimate heritability. This formula is so simple!
However, Falconer emphasized as early as 1967 that it did not apply to etiologically heterogeneous diseases (thus ultimately to any human disease).
@SashaGusevPosts What a wise resolution...And yet, should we not continue to protest against those who speak of the heritability or PRS for IQ by making assumptions that make no sense?
@FranckRamus@LEXPRESS@sup_recherche@Sante_Gouv@sretailleau@Etienne_Pot C’est super que vous vous battiez pour que l’éducation nationale reconnaisse certains handicaps à l’apprentissage scolaire et mette en place des dépistages précoces de problèmes cognitifs ... mais sans pour autant faire dire n’importe quoi à la génétique statistique!