Caro

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Jake Shields @jakeshieldsajj]

Imagine being kidnapped and raped then having your kidney stolen

It’s an entire nation of psycho serial killers

[nana @naneinstein_]

I won’t shut up about this, pancreatic cancer kills a person in 4 months btw, it’s resistant to radiotherapy, and fucks two essential parts of the metabolism. this could change the world

[Hend Amry @LibyaLiberty]

I can’t believe social media did this.

[Jake Shields @jakeshieldsajj]

How do you defend this?

[Zachary Foster @_ZachFoster]

Nothing to see here, just Israeli terrorists doing more terrorism

[Lowkey @Lowkey0nline]

Gaza.

[4ocean @4ocean]

Heartbreaking scenes like these are becoming all too common. But we refuse to accept this as the new normal.

Our 4ocean cleanup crew is on a mission to turn the tide against single-use plastic pollution. Together, we're reclaiming the ocean, one cleanup at a time.

How are you breaking this cycle of plastic pollution?

#plasticpollution #plasticfree #oceanlove #oceanconservation

[301🇦🇲 @301arm]

BREAKING: Israeli Public Broadcasting Corporation broadcaster Kan 11 insults the 1,700-year-old Armenian presence in Jerusalem.

After Armenia’s Eurovision performance on May 15, a Kan 11 commentator said:

“I can’t believe we gave ‘these’ guys an entire quarter in Jerusalem.”

Then added: “Survivor — that’s how we feel after watching this song.”

For the purpose of historical clarity and accuracy:

• The Armenian presence in Jerusalem dates back to 301 AD, when Armenia became the first Christian nation.

• The Armenian Quarter was not “given.” It was built, stone by stone, by Armenians over centuries and under empires and dynasties that have long since vanished.

• It is not a gift — it is a legacy. One that is preserved, nurtured, and defended to this very day.

Such remarks are not just ignorant — they are offensive to the collective memory of Armenians and their millenial-old contributions to the culturual, social, and economical fabric of Jerusalem. The Armenian community in Jerusalem has survived genocide, exile, and erasure — and yet is still, against all odds, here. Still building. Still protecting. Still Armenian.

Kan 11 owes the Armenian people an immediate public apology.

301 correspondent: @kbalian90

[ⴰⵀⴰⵣ 🇩🇿 @jesuistouareg]

That’s the church that Israel bombed and tried to say Hamas did it by the way

[Ilian @ilianikh]

Pour ceux qui disent que la délégation palestinienne est petite en même temps… 🇵🇸💔

[AbortionChat @AbortionChat]

….we literally tried to warn you that this is what happens when abortion access isn’t accessible.

[Eliès 🇩🇿 @Elies13700]

Bon de préciser qu'ils sont si peu dans le délégation Palestinienne car les autres athlètes ont été tués, emprisonnés, torturés et blessés !!

#ceremoniedouverture #Paris2024

[Drew Pavlou 🇦🇺🇺🇸🇺🇦🇹🇼 @DrewPavlou]

Andrew Tate recorded a sex tape beating a 14 year old girl.

Can’t wait until this pedo is locked up

[lotus @histxrianx]

THIS!!! don't call yourself a feminist if you're ignoring this

[𓂆 deeja🫒 @deedeehimawari]

i fucking hate this world. again, LOOK AT THE KIDS

[Matt Kennard @kennardmatt]

We must not allow these images to become normalised. These are all our children.