Colin Nichols Lab @colinnicholslab.bsky.social

Posting from Colin Nichols' electrophysiology lab at @WUSTL. Focused on ion channels biophysics & role in physiology and pathology.

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Follow us on @bluesky !
https://t.co/TmX4i9j5kF

[Harraz Lab @Harraz_Lab]

Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome
@vesselman @ColinNicholsLab @JCI_insight https://t.co/2qDAflvnTq

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

The study has important implications both for monogenic KATP channel diseases and for more common brain pathologies. 4/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" @Nyorkster91 @SageJournals
https://t.co/A5SsHdzAZu
A 🧵 1/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

We reveal the dramatic effects of either increasing or decreasing SUR2/Kir6.1-dependent KATP activity on NVC, whether pharmacologically or genetically induced. 3/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Join us today for a new exciting CIMED seminar! @zubcevic_lejla @WUSTL

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

We show that insulin secretion can be restored when intracellular Ca2+ is artificially elevated by increasing extracellular Ca2+. 4/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Check out our new publication "Loss of β-cell KATP reduces Ca2+ sensitivity of insulin secretion and Trpm5 expression" @Nyorkster91 @ADA_Pubs
https://t.co/HlYykfxmrf
A 🧵 1/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

In this study we examine this phenomenon, demonstrating that the lack of insulin secretion is the result of an apparent reduced sensitivity to Ca2+. 3/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Today!

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Next Monday, join us for a new exciting CIMED seminar! @RohacsTibor @WUSTL

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Next Monday, join us for a new exciting CIMED seminar! @RohacsTibor @WUSTL

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Join us today for a new exciting CIMED seminar! @WUSTL

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Join us today for a new exciting CIMED seminar! @WUSTL

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Cell bio department retreat! @MariaSRemedi

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Excellent thesis defense by Dr. Gao! Congratulations Jian, we are very proud of you! 🥳

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Join us today for a new exciting CIMED seminar! @SlavBagria @WUSTL

[WashU Medicine Endocrinology @WashUMedEndo]

Congratulations to Drs. Irfan Lodhi, Jeffrey Millman, Maria Remedi, and Julie Silverstein on achieving full professorship in their careers! Learn about each of their journeys: https://t.co/tikXeoPGLY. @JeffreyRMillman @LodhiLab @WUDeptMedicine

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

The specific location of the variant also reveals an unrecognized functional role of the first glycine in the signature motif of the nucleotide binding domains in NBD1 of SUR2 subunits. 4/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Check out our new publication
"A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1" https://t.co/1ufBRLclQl
A 🧵 1/n

[Colin Nichols Lab @colinnicholslab.bsky.social @ColinNicholsLab]

Functional assays reveal that KATP channels containing this mutation exhibit reduced sensitivity to inhibitory ATP compared to WT, providing a molecular explanation of the condition. 3/n