Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity#T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed
Excited to share our new publications working with @AlbertHKimMDPhD. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression https://t.co/6Oe4P6JF9w
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH https://t.co/sysztNi1oW
Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use? Our new study found that carnitine biosynthesis is crucial for fuel switching https://t.co/YgqmN2kzjn
Peroxisome-dependent ether lipid down regulation is also a prominent feature of ME/CFS patient lipid profiles. Our prior work and this new study call for a clinical trial of sodium phenylbutyrate that can boost peroxisome function on Long COVID 🙏🙏@NIAIDNews
Excited to see this work published in Nature Metabolism! This study provides new insight into how normally stable adipocytes can be mobilized under extreme metabolic stress, independent of sympathetic signaling. Congrats to @schellerlab and the team!
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴
Full article here: https://t.co/9zxBai83Zx
Unlike the white fat cells you may be familiar with, brown fat cells use energy to produce heat. NIH-supported researchers identified a previously unrecognized way these cells use energy. The findings suggest a potential way to promote weight loss by increasing heat generation in brown fat cells. https://t.co/HfS2N0nZdp
Thrilled to share our work on adipose tissue heterogeneity out today in @emboreports! Huge congrats to first author Hoang Bui, Juli Hansen, and our special collaborator @valelosardo for guiding us through the mysterious world of single-cell analysis! https://t.co/1j46WG50D2
Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity#T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed
Happy to share new work led by outstanding former grad student Kubra Akkaya! Following up on our previous work, we show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell function and proliferation, shaping epithelial homeostasis and regeneration.