Irfan Lodhi

Professor of Medicine at Washington University| Studying lipid metabolism| Adipocyte Biology, BAT, Diabetes, NAFLD, Obesity, Peroxisomes| PhD UMICH

[Irfan Lodhi @LodhiLab]

Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed

[Irfan Lodhi @LodhiLab]

@RazaniLab @XiangyuZ0321 @PittDeptofMed @PittVMI Great news! Congratulations, Xiangyu!

[Irfan Lodhi @LodhiLab]

@yushengyeh @American_Heart @PLRC_PittLiver @PittMedicine Congratulations, Yu-Sheng!

[Irfan Lodhi @LodhiLab]

@CreweLab Congratulations, Clair!

[Babak Razani, MD, PhD Laboratory @RazaniLab]

New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their @atvbahajournals review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
https://t.co/L9L4V2I8d2

[Jeffrey Millman @JeffreyRMillman]

Excited to share our new publications working with @AlbertHKimMDPhD. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression https://t.co/6Oe4P6JF9w

[Andrea Galmozzi @GalmozziAndrea]

Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure | Science https://t.co/kn8tBgpozh

[Cell Metabolism @Cell_Metabolism]

Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH https://t.co/sysztNi1oW

[Shingo Kajimura Lab @KajimuraLab]

Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use?  Our new study found that carnitine biosynthesis is crucial for fuel switching https://t.co/YgqmN2kzjn

[Jie Sun @Jie_Immunology]

Peroxisome-dependent ether lipid down regulation is also a prominent feature of ME/CFS patient lipid profiles. Our prior work and this new study call for a clinical trial of sodium phenylbutyrate that can boost peroxisome function on Long COVID 🙏🙏@NIAIDNews

[Irfan Lodhi @LodhiLab]

Excited to see this work published in Nature Metabolism! This study provides new insight into how normally stable adipocytes can be mobilized under extreme metabolic stress, independent of sympathetic signaling. Congrats to @schellerlab and the team!

[Scheller Lab @schellerlab]

Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴

Full article here: https://t.co/9zxBai83Zx

[Irfan Lodhi @LodhiLab]

@JeffreyRMillman @NIH Thanks, Jeff! It’s great being your neighbor.

[Irfan Lodhi @LodhiLab]

Thank you @NIH for highlighting our recent @Nature paper! Extremely grateful for the support that made this work possible.

[NIH @NIH]

Unlike the white fat cells you may be familiar with, brown fat cells use energy to produce heat. NIH-supported researchers identified a previously unrecognized way these cells use energy. The findings suggest a potential way to promote weight loss by increasing heat generation in brown fat cells. https://t.co/HfS2N0nZdp

[Irfan Lodhi @LodhiLab]

Shingo, thanks so much for highlighting our recent paper! Looking forward to exploring this further.

[Shingo Kajimura Lab @KajimuraLab]

Super interesting ! A new UCP1-independent thermogenic mechanism in peroxisomes https://t.co/Ga6ZKhbScU

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Novel UCP1-independent thermogenic mechanism identified https://t.co/oLatcE8bdT

[Andrea Galmozzi @GalmozziAndrea]

Thrilled to share our work on adipose tissue heterogeneity out today in @emboreports! Huge congrats to first author Hoang Bui, Juli Hansen, and our special collaborator @valelosardo for guiding us through the mysterious world of single-cell analysis! https://t.co/1j46WG50D2

[Nature Metabolism @NatMetabolism]

A consensus guide to preclinical indirect calorimetry experiments https://t.co/55mwFI9k8j

[Irfan Lodhi @LodhiLab]

@taehwachun @Nature @Jessielxj2 @WashUDeptMed Thanks, Tae-Hwa!

[Irfan Lodhi @LodhiLab]

Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed

[Maria Mihaylova @MariaMMihaylova]

Happy to share new work led by outstanding former grad student Kubra Akkaya! Following up on our previous work, we show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell function and proliferation, shaping epithelial homeostasis and regeneration.

[Irfan Lodhi @LodhiLab]

@arpit_science Thanks! Peroxisomes finally getting the respect they deserve.

[Irfan Lodhi @LodhiLab]

@kazaklab @GalmozziAndrea Thanks, Lawrence!