Scheller Lab

Neuroskeletal Biology Laboratory (NSBL) @WUSTLmed. Executive director @wustlcrm. President @ISBM_society. Nerves. Bones. Metabolism. Encouragement. 🔬🦴🧠❤️

[Scheller Lab @schellerlab]

Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴

Full article here: https://t.co/9zxBai83Zx

[Nature Metabolism @NatMetabolism]

A catecholamine-independent pathway controlling adaptive adipocyte lipolysis https://t.co/GxeTKr1WtO

[PsyPost.org @PsyPost]

A new study reveals how the brain triggers the breakdown of stable fat cells that normally resist diet and exercise. This discovery provides evidence for how severe wasting diseases cause dangerous weight loss in vulnerable patients. https://t.co/wLsmrSWFQB

[WashU Office of Neuroscience Research @WashUONR]

A team led by @schellerlab @WashUDeptMed, with @XiaoZhang1994 and others identified a potent pathway that begins in the brain and leads to loss of all body fat without reducing food intake. Findings published in @NatMetabolism.

#WashUNeuroCommunity
https://t.co/OXQoWt4fhu

[Scheller Lab @schellerlab]

Specific brain signals rapidly eliminate body fat in mice https://t.co/MEGelMecSK

[Erwin Loh @erwinloh]

Specific Brain Signals Rapidly Eliminate Body Fat in Mice

Sustained injection of leptin into the brain was shown to unlock stable adipocytes, leading to complete loss of body fat.

Researchers at WashU Medicine have identified a potent pathway that begins in the brain and leads to loss of all body fat without reducing food intake.

In mice, sustained injection of leptin, a hormone, into the brain was able to unlock the stable adipocytes by putting the body into a state of low glucose and insulin. This reduced the inhibitors of fat breakdown, causing complete loss of body fat within days, even though the mice were still eating normally.

Source in comments.

[Nature Metabolism @NatMetabolism]

RESEARCH | @schellerlab (WUSTL, US)

Stable #adipocytes resist lipolysis in healthy states but are highly susceptible to a #catecholamine-independent, #neurosystemic pathway-driven catabolic state🐭

https://t.co/eGfHF4vhKl

[Medical Xpress @medical_xpress]

#Activation of specific brain signals in mice triggers rapid, complete loss of body fat without reducing food intake, highlighting a potent neural pathway that regulates resistant fat stores. @wustl https://t.co/br3NlIemV2 https://t.co/l4wZHIr8RC

[Nutrition Science @NutrioSci]

New Pathway Controls Fat Breakdown Without Catecholamines

#Obesity #Nutrition #nutrients #MedX

[Scheller Lab @schellerlab]

@DrAhmedAlSaedi Thank you, Ahmed! We look forward to seeing where the work goes next.

[Scheller Lab @schellerlab]

Many thanks to Dr. Affinati and Dr. Schwartz for their insightful commentary on our recent article in @NatMetabolism. 🙏 We are truly honored. Original manuscript link here: https://t.co/n3M9ObxUaK

[Nature Metabolism @NatMetabolism]

Chewing the fat: a novel mechanism for lipolysis https://t.co/FKrkeS6Cz5

[Dr Singularity @Dr_Singularity]

paper https://t.co/1PBGeVBSEY

[Scheller Lab @schellerlab]

Exciting work by @AriellaStudies that we were proud to be a part of!

[Dr Singularity @Dr_Singularity]

Big anti aging news

Scientists Identify Core "Aging Genes" Shared Across Species. Silencing Them Extends Lifespan

Researchers publishing in Aging Cell have pinpointed a set of core genes that drive aging across multiple species, from humans to worms.

By analyzing 25 large gene expression datasets and testing the results in C. elegans, they found 6 key genes whose suppression extended lifespan by up to 15%.

These genes regulate immune activity, tissue maintenance, and DNA stability, and many are already linked to age related diseases like Alzheimer’s and macular degeneration.

The findings reveal universal aging mechanisms and new targets for anti aging therapies.

[Ariella Coler-Reilly🏳️‍🌈 @AriellaStudies]

That's me! I'm Researchers! 😁
Very nice to see this excitement. 🎉

Original paper here: https://t.co/V3LmI3wUlU

[Scheller Lab @schellerlab]

#StandUpForScience2025

[Scheller Lab @schellerlab]

@DrAhmedAlSaedi Thank you for your leadership on the ISBM ECI Committee over the past two years! The momentum and enthusiasm in our early careers is so exciting to see. The future is bright because of stars like you. 🌟

[International Society of Bone Morphometry (ISBM) @ISBM_society]

🎬And that's a wrap! Thanks to everyone that made #ISBM2024 a success. We hope you met some new buddies and left with new tools, ideas, and inspiration. We look forward to staying in touch until we see you again in London at ISBM 2026!

[Scheller Lab @schellerlab]

Followed up by a very neat live demo for setting up an AI-assisted image registration pipeline! Lots to learn for the biologists - but very cool to see an expert go through the steps in real time.

[Scheller Lab @schellerlab]

Live responses from the room on challenges in bone morphometry. Ok… who typed idiots? 😂😂😂 #ISBM2024

[Scheller Lab @schellerlab]

So difficult to pick just one! Great discussion and lots of questions at the #ISBM2024 training workshops. @ISBM_society

[International Society of Bone Morphometry (ISBM) @ISBM_society]

Congrats to our ASBMR Hartmut Malluche Early Career Investigator Awardees. We are proud of all of you #ISBM2024 @ASBMR