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Esta cuenta pretende acercar el conocimiento científico al público en general.

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@_MCRicardo_ @AntelmPujol Hola! A cuales problemas Gastrointestinales refieres? tienes a mano bibliografía para leer al respecto?

[Antelm Pujol, MD PhD @AntelmPujol]

😴🚩 ¿CREATINA PARA LA FALTA DE DESCANSO NOCTURNO?

⚠️En persona que han dormido 0-2horas la noche anterior, la ingesta de 0,35 gramos de creatina/kg de peso corporal (20-25 gramos de creatina) EN UNA SOLA DOSIS produce:

⇧⇧Aumento del rendimiento cognitivo.
⇧⇧Aumento de la velocidad de procesamiento mental.
⇧⇧Mejoría del metabolismo celular.

🤝Una gran opción para turnos nocturnos y/o guardias.

[Mauricio Ambriz @AmbrizMau]

Síndrome cardiopulmonar por Hantavirus:

N Engl J Med 2020;382:1544-53.

[Nutrients MDPI @Nutrients_MDPI]

📖Paper Title: #Onion Peel Extract Prevents Intestinal Inflammation via AMK-Activated Protein Kinase Activation in Caco-2/HT-29 Cells
by Olugbenga Balogun et al.
🛎️link: https://t.co/nBZVkZsxBg

[Ahmed Ata @Ahmedata7777]

Electrical conduction system of the heart:

1. Sinoatrial (SA) Node: Often called the heart's natural pacemaker, it initiates the electrical impulse.

2. Bachmann's Bundle (Interatrial Tract): Conducts the impulse from the right atrium to the left atrium.

3. Anterior Internodal Tract: One of three pathways connecting the SA node to the AV node.

4. Middle Internodal Tract (Wenckebach's pathway): The second internodal pathway.

5. Posterior Internodal Tract (Thorel's pathway): The third internodal pathway.

6. Atrioventricular (AV) Node: Acts as a gatekeeper, briefly delaying the signal to allow the ventricles to fill with blood.

7. Bundle of His (Atrioventricular Bundle): The bridge that carries the signal from the atria into the ventricles.

8. Right Bundle Branch: Carries the electrical impulse to the right ventricle.

9. Left Bundle Branch: Carries the electrical impulse to the left ventricle.

10. Left Anterior Fascicle: A branch of the left bundle that stimulates the upper/front part of the left ventricle.

11. Left Posterior Fascicle: A branch of the left bundle that stimulates the lower/back part of the left ventricle.

12. Purkinje Fibers: The final network of fibers that spread the impulse throughout the ventricular muscle, causing contraction.

》Short debate questions:

“Are the classical anterior, middle, and posterior internodal tracts real structures, or just functional pathways in atrial myocardium?”

“If discrete internodal tracts are not clearly proven anatomically, how does the impulse travel so quickly from the Sinoatrial Node to the Atrioventricular Node?”

[Mmm @mir4max]

@Mappy6984 Why is it funny to watch animals being hurt? Explain please.

[Julio @JulioFdez79]

AINES

LOS AlNEs son medicamentos que reducen dolor, inflamación y fiebre.

[Top Biomedical Science @imedverse]

Summary of STAT-regulated T helper cell.

Lineages Treg is highlighted in an orange square.

Open Access
https://t.co/EjwldcG2mH

#MedEd #MedX #immunity #NobelPrize

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@TrackYourHeart Liver

[William A. Wallace, Ph.D. @WilliamWallace]

It’s not so much about how long you move; it’s how often.

A growing body of research shows that you don’t need long gym sessions to improve health. The 2025 expert consensus statement (citation below) highlights how brief, frequent bursts of movement throughout the day, called short bouts of accumulated exercise (SBAE), can deliver many of the same benefits as structured workouts.

1️⃣ What Is SBAE?

Short bouts of accumulated exercise are small sessions of movement, often 2–10 minutes, performed several times per day.
They “add up” to meaningful totals of physical activity over time.
🟢 Example: Walking up the stairs, doing air squats after a meeting, or brisk walking after meals.

2️⃣ Why It Works
Each short bout boosts blood flow, glucose control, and mitochondrial activity, while breaking up long periods of sitting — a key driver of metabolic and cardiovascular risk.
🟢 Example: Even a 2–5 minute walk every 30 minutes can help regulate blood sugar and reduce insulin spikes.

3️⃣ How to Apply It (Prescription Recommendations)

The consensus provides a practical “exercise prescription” for SBAE:
Frequency: Move every 30–60 minutes, several times daily.

Intensity: Start light to moderate; progress to brief vigorous bouts if tolerated.

Duration: Aim for ≥150 minutes per week of total activity, accumulated in short bouts.

Timing: Post-meal movement is especially beneficial for glucose control.

Type: Prioritize bodyweight or resistance-based movements that activate large muscle groups.
🟢 Example: Three 10-minute brisk walks daily = similar cardiovascular benefit as a single 30-minute session.

4️⃣ Key Benefits of SBAE

Improves insulin sensitivity and glycemic control

Enhances vascular function and blood flow
Reduces inflammation and oxidative stress

Supports cardiometabolic health and mental well-being
🟢 Example: Studies show SBAE improves blood pressure and mood, even in people who don’t meet standard exercise guidelines.

5️⃣ Who It’s For

SBAE is feasible for nearly everyone, including older adults, people with limited mobility, and those managing chronic conditions like type 2 diabetes or cardiovascular disease.
🟢 Example: Breaking up sitting with 2–5 minutes of movement is a practical, accessible strategy for desk workers and older adults alike.

6️⃣ Future Directions

The consensus calls for research into:
Optimizing intensity and timing for different populations.

Using wearable tech and AI to track and personalize SBAE.

Integrating SBAE into clinical guidelines for chronic disease prevention.

You don’t need a gym or an hour - just consistency.
Short bouts of accumulated exercise break the “sit–disease” cycle, enhance metabolic health, and make movement accessible for all.

Yin M, Chen P, Mao L. Expert Author Group. Short bouts of accumulated exercise: Review and consensus statement on definition, efficacy, feasibility, practical applications, and future directions. J Sport Health Sci. 2025 Sep 18:101088.

[enGrama Psicología Ψ @enGramaPsico]

¿BUSCAS UN CAMBIO EN TU VIDA?

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@EndoCollabcom send it

[Keith Siau @drkeithsiau]

Recap on the causes of diarrhoea 💡

📸: Netter's Illustrations

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https://t.co/bVpYULt4bu

[Tay @BioTay]

1/2 Los cerdos no están "atrapados en el presente"

Evidencias de memoria episódica en minicerdos
El experimento es una adaptación de uno previo diseñado para perros y en el que se usa el olfato. Los minicerdos lo han hecho igual que los perros

(preprint) https://t.co/rheiYxBfim

[William A. Wallace, Ph.D. @WilliamWallace]

This post does not suggest that vitamin deficiencies are causal to all cases of depression, or even that they play a primary role in some cases of depression. This post is meant to convey ways in which vitamin deficiencies can contribute to the etiology of depression [this may be relevant in more cases of depression than is currently recognized (not only with these specific vitamins)]. Before taking any supplements or attempting any adjunct therapies for depression, seek the advice of your primary healthcare provider. This is not medical advice.
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Deficiencies of Vitamin D, Vitamin B12 and B6, and Folate/Folic Acid and their Involvement in Depression
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Vitamin B6, B12, and Folate are components of homocysteine metabolism. All three are involved in the synthesis of serotonin. The three of these vitamins also share a relationship with Vitamin D. Vitamin D regulates the expression of TRPH2 (Tryptophan hydroxylase 2), the rate-limiting enzyme responsible for serotonin synthesis in the brain. Vitamin D’s roles for mood regulation have similar, or nearly identical, outcomes as the homocysteine metabolism.
-
From: Jeffries (2021). Vitamin Deficiency and Depression

[Brian Grimm, M.D. @DrGrimmMD]

Here’s the gold hiding in plain sight:
Sleep might not start because you run out of energy…
It might start because you have too much.

This Nature paper reveals that electron surplus in mitochondria—not depletion—can trigger sleep pressure. It’s not just about needing rest, it’s about dissipating a bioelectric overload.

That surplus creates charge density. And when the flow backs up… you get a cellular logjam. The system shifts into a mode designed to reset the field.

Adenosine? It’s the signal that says “dump the extra.”
It builds when ATP is used, and it hyperpolarizes neurons—priming you for sleep.
Funny, we use adenosine to reset cardiac rhythms in SVT too. That’s not just pharmacology… that’s bioelectric pattern control.

—

Now zoom out:
•UCP4 in this diagram? It dissipates charge by uncoupling protons from ATP production.
•mito-dR? That’s red light—literally rebalancing charge pressure.
•sesB? A gatekeeper of flow. Too much pressure and it’s time to reboot.

This isn’t “you’re tired so you sleep.”
It’s: “Your field lost coherence. Sleep is the cellular sweep.”

—

Want the deeper dive? I just started a Field Signal Lab series unpacking exactly this kind of wiring:

This is why I say: You’re not broken. You’re out of phase.
Let’s get the signal flowing again.

[Tay @BioTay]

Durante esta semana se pueden descargar gratis los libros de Philosophy of Biology de Cambridge Elements, echadle un ojo porque creo que hay libros muy buenos aquí.

Desde la filosofía del moho mucilaginoso hasta la selección cultural

https://t.co/FTp8FApvXn