#ITQBNOVA’s Open Day is back! 🧪✨
Explore our science with lab visits, talks, experiments, a scientific escape room and more!
📅 March 15 (Sat), 10am-5pm
🎟️ Free entry
Visit us and bring your family and friends!
Stay tuned for details.
@OeirasValley@NOVAunl
🚨 New preprint alert! 🚨 We uncover key aspects of how the #SARSCoV2 nucleocapsid protein self-assembles and undergoes LLPS—critical for viral behavior. Using #SAXS and #NMR, we reveal how disordered regions drive complex formation. Explore the details: https://t.co/G8DBj7IGwN
As someone who works in protein chemistry and structure, I’m thrilled to see the 2024 #NobelPrize in Chemistry awarded to David Baker, Demis Hassabis & John Jumper. Their work is transforming the field. Congrats to all! #ProteinChemistry#NobelPrize2024
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Boy: Do not try and bend the protein. That's impossible. Instead... only try to realize the truth.
Neo: What truth?
Boy: There is no protein structure.
Neo: There is no protein structure?
Boy: Then you'll see, that it is not the protein that bends, it is only yourself.
Bacteria that turn water into ice❄️ 🔬
Pseudomonas syringae contains special surface proteins that act like scaffolds for ice nucleation!
#science#research#microbiology#biochemistry
Excited to share that @CordeiroLab presented our latest research at #IBSBC2024! A great opportunity to showcase our work @itqbnova and connect with fellow scientists and friends.
We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. https://t.co/8fOYWffXLv
Summer Science @itqbnova is waiting for you! ☀️🧪
If you're an undergraduate student, from July 15-19th you'll get the chance to develop a lab project & take part in our social activities. 🌊
Apply by June 10th: https://t.co/g1f7pmensV .
@NOVAunl@OeirasValley
3/3 In eukaryotic cells, protein disorder is critical for signaling and regulation. Although intrinsically #disorderedproteins (IDPs) are a small fraction of typical bacterial proteomes, Tir helps us make the case that IDPs have a critical role at the host-bacteria interface.
🎉 Exciting news! Our paper, "The Pathogen-Encoded Signaling Receptor Tir Exploits Host-Like Intrinsic Disorder for Infection" is officially published! @CommsBio,📚 Grateful for the collaboration and hard work of all involved. Read it here: https://t.co/aynMIJkO5K
2/3 Using various state-of-the-art biophysical methods (#SAXS, #NMR#microscopy), we show that Tir, a bacterial effector, exploits host-like disorder to rewire cellular processes via dimerization, lipid binding, and phosphorylation, revealing a versatile strategy for infection.
1/3 Have you ever wondered how pathogens hijack the host? 🦠 In our latest research, conducted in collaboration with @itqbnova, @LeibnizFMP, @NetBioinfoMRS, and @TheFrankelLab, we delve into the fascinating world of host-pathogen interactions.
Happy to share the publication of our paper in @Nature
Conformational ensembles of the human intrinsically disordered proteome
Work led by @GiulioTesei and @AnnaIdaTrolle. I'll post more later, but for now here is a link:
https://t.co/b3aZ6BbGpB
and a short movie about the work
@shaharsu I just read a paper where the authors show how structural biases in IDP ensembles found in vitro are recapitulated inside human-derived cells, you should check it out @shaharsu ! https://t.co/5AbyIwb9Jh
Congratulations to Guillem Hernandez Gras on the successful completion of his PhD in #MolecularBiosciences@itqbnova! 🎓👏 It's been a privilege to supervise his impactful research on 'Structure and Dynamics of Pathogenic Scaffold Proteins.'