@farhadparv27723 PE, S1Q3T3 on EKG, obstructive shock with low PCWP and increased CVP. Additionally, you’d see V/Q mismatch. Look for a saddle shaped picture on the CT
@latrogenicMind The important part is that you are already losing volume in nephrogenic DI but its mainly the loss of “sodium” that triggers your body to increase reuptake overall when thiazide diuretics hit the Na-Cl channels in the DCT.
Almost one year of telling myself to be consistent! Damn cant believe I started this page almost a year ago to keep myself accountable for preparation of usmle step 1.
@USMLERounds A. RTA type 1, probably some lymphocytic infiltration at collecting ducts levels [alpha intercalated cells] leading to impairement of the H Atpase channel (is that the one)? This would cause NAGMA, less H to bind in the tubule so low NH4+ in the urine. HCO3 would be low to buffer
@hania__imran Berger’s is IgA nephropathy -> you can see synpharyngitis along with the kidney manifestations like hematuria etc
Buerger’s disease is thromboangitis obliterans. If you see cold extremities in someone who smokes a lot, relatively young, you would have it on DDx over atheroma
@USMLERounds Could argue against esophagus being retroperitoneal. It is more of an extraperitoneal structure apart from the little area below diaphragm which is intraperitoneal.
@VPrasadMDMPH No we should not. Slop gets identified quite easily if u have a keen eye (which im sure most of PDs do). Even if you research for the sake of it in your initial med school days, u learn something and that learning exposure is enough to pursue what u’d love to explore later on.
@Zeeshan_Ghani24 Enac channels stuck on in Liddle syndrome. GOF auto dominant mutation.
Additionally, licorice poisoning that inhibits 11B hydroxysteroid dehydrogenase can lead to similar symptoms as well.
@Ssonali124@DrKamleshDarji1 Increased gfr happens after your efferent arteriole has undergone hyaline arteriolosclerosis and there is mesangial expansion around the filtration barrier. Aftermath is increased gfr alongside microalbuminuria