Bernat Crosas

Biomedical researcher at the Institute of Molecular Biology of Barcelona. Our discoveries could help people

[Bernat Crosas @CrosasLab]

Well done, sister!

[Mercè Crosas @mercecrosas]

Thanks @CODATANews community! I look forward to working with all of you to help improve access and use of data for better science.

[Bernat Crosas @CrosasLab]

Extraordinary mechanistic dissection of proteasome activities and definition of roles of ubiquitin beyond substrate recruitment. Always @AndyMartinLab !
https://t.co/fWFLGQxS7S

[Zuzana Hodakova @ZHodakova]

Our paper describing the 3Å #cryoEM structure and chain-elongating function of UBR5, one of the largest HECT E3 ligases, is now out! at https://t.co/dy9kMqKBqj

[Bernat Crosas @CrosasLab]

If you're interested in degrading the "undruggable", you should pay close attention to what aptamers can do for you. #TPD https://t.co/ti3soaX7P2

[Bernat Crosas @CrosasLab]

@biomiko @matthias_muhar It has been fantastic to participate to the #TPD webinar today, with great colleagues and audience!!

[Mikołaj Słabicki @biomiko]

Join us next week for #DegradoZoom on July 6th, 12pm EST:
Bernat Crosas @CrosasLab IBMB: Development of proteolytic chimeras based on direct 26S proteasome targeting
Muhar Matthias @matthias_muhar ETH Zürich: A chemical degron marks C-terminally modified proteins for degradation

[Ateneu Barcelonès @AteneuBCN]

Sala plena en el retorn de @CienciaAteneu!

📊 De què parlem quan parlem de dades? Realitats, Mites i Futurs

Amb Pau Garcia, de @domesticstream i @mercecrosas, del @BSC_CNS

[Mikołaj Słabicki @biomiko]

July 6th, 12pm EST
Bernat Crosas @CrosasLab (IBMB) 26S proteasome PROTACs.
@matthias_muhar (ETH Zürich) C-terminal chemical degron.

[Ingo Hartung @HartungIngo]

Certain MEK inhibitors induce a complex between #MEK & difficult-to-degrade #cRAF. This allows bystander degradation of recalcitrant cRAF w/ #PROTACs targeting MEK. Excellent study by the Duncan & Jin labs @FoxChaseCancer @IcahnMountSinai @biorxivpreprint https://t.co/cE8i5lUsw7

[Bernat Crosas @CrosasLab]

Fascinating parallel architecture and functioning of Npl4-Ufd1-CDC48 and 19S Proteasome complexes. The same evolutionary solution put together twice in the same pathway: Ubiquitin recognition, MPN domains and ATPase engine. #TPD
https://t.co/wQX7Hmzrsi https://t.co/wLSEDi93rP

[Bernat Crosas @CrosasLab]

Can allostery be decoded? the complexity of allosteric regulation, essential to understand cell biology and pharmacology, approached from different standpoints in two outstanding papers:
https://t.co/QF29OfIDiE
https://t.co/j09FI4iBaV

[Bernat Crosas @CrosasLab]

Let's be clear: this is beauty.
(historical picture of Ordesa valley, #MontePerdido presiding, at the heart of Pirineo de Huesca)

[Bernat Crosas @CrosasLab]

Spectacular tuning effect of Usp14 mediated by 3 allosteric checkpoints that make the 26S proteasome even more sophisticated. Thanks Y. Mao, D. Finley and all contributors. Retain in memory.
https://t.co/581v4lId4f

[Bernat Crosas @CrosasLab]

The 26S proteasome is this fantastic machine that nature has created to achieve homeostatic control of intracellular protein content in a timely and perfectly regulated manner. Most of the strategies used in the #TPD field rely on that. #Proteindegradation

[Bernat Crosas @CrosasLab]

@monteiro_dalmo In principle it could be feasible, as long as you have good ligand(s) of the non-functional protein, adaptable chemistry and then a good experimental model.

[Bernat Crosas @CrosasLab]

If we have to have northern lights, let’s have northern lights.

[Joan Roig @Nek967]

https://t.co/Eiryf71T6Q

In where we show that dynein adaptors, like most things in life, are also regulated by phosphorylation.

Featuring: BICD2 and PLK1. You heard that right: no NEKs this time (but, of course, just wait).

[Ventura's Lab @PPMC_UAB]

Today we have received the Narcís #Monturiol medal from #conseller @quimnadal @recercauniscat
This wouldn’t have been possible without an amazing Team 🔝🔝
and the continued support of @UABBarcelona @IBB_UAB @Biociencies_UAB
Thanks ☺️

[Dr. Rebecca Wallings @RebeccaWallings]

I dont want to be part of a system that is so horrifically broken and serves to benefit the few 🧵5/5

[Bernat Crosas @CrosasLab]

@a_m_mastroianni outstanding end!