Cryonics and Cryopreservation Research Network

Group of UK scientists and international advisors aiming to advance research in cryobiology and cryonics. Our goal is to use technology to defeat death.

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

Cryonics: fantasy or a bridge to the future? #TEDtalks @imperialcollege @jpsenescence @TEDx https://t.co/ph3RBauVEq

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

How plausible is future revival after cryopreservation?

In a survey of US physicians, the median estimated probability that cryopreservation could retain sufficient neural information for future patient revival was 25.5%.

https://t.co/W7m0q2As4w

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@cremieuxrecueil @danielsil44 Great post! Have you considered biostasis?

[João Pedro de Magalhães @jpsenescence]

Gene expression can be used to predict age and mortality 🚨

Impressive study from @gladyshev_lab @harvardmed using RNA-seq data to develop accurate transcriptomic clocks across mammalian species (inc. humans) and tissues to predict age, lifespan and mortality. A great example of the power of big data in aging research.

Major processes changing with age include inflammation, mitochondrial function, epigenetic regulation, cell cycle (inc. markers of cellular senescence) and extracellular matrix remodeling.

These clocks will have applications in personalised medicine, drug discovery and clinical trials. They also suggest some degree of coordination of aging changes.

However, many questions remains. Are age-related transcriptomic changes drivers of aging or merely passengers? In other words, if we normalized these aging changes back to youthful levels, would this be beneficial, detrimental, or have no effect?

And with so many aging clocks now available, how will researchers determine which ones are most biologically meaningful and clinically useful?

Link to original paper:
https://t.co/S7Cu17YqCu

My thoughts on the study:
https://t.co/xYAguwvsiu

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

Electric fields for warming cryopreserved tissue
https://t.co/T1A4To9BXT

[João Pedro de Magalhães @jpsenescence]

This is all solid advice on sleep, diet, exercise and lifestyle. I encourage folks to follow it.

But we're not going to sleep our way to 150 years. We need interventions that target the biology of aging to make real progress in longevity.

[Andrei Panferov @andreypnfrv]

Biogerontology will not save most people alive today. Even in an optimistic scenario, it will likely deliver gradual therapies: less inflammation, better immunity, less frailty, some organ improvements, maybe +5–15 years for some people. But not mass rescue from death.

There are around 8.2 billion people in the world today. Global life expectancy is around 73 years; as the population ages, the number of deaths will rise. WHO gives global life expectancy as 71.3 years in 2021; the UN gives 73.3 years in 2024.

Replacement is hard to scale and will not rejuvenate everything — for example, the blood vessels of the brain.

Without a radical change in strategy, several billion people alive today will die before true negligible-senescence medicine arrives. Five billion deaths is my lower estimate. Realistically, it will be more.

This leads to an unpleasant conclusion:

We need not only biogerontology, but a strategy for survival through death.

Without cryonics, immortalism is effectively agreeing to write off almost everyone who will not live long enough to reach radical medicine.

Do we want death for our parents and for 80% of everyone we know?

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@andreypnfrv 💯

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@VraserX He's working on combining interventions, which is interesting but not better than caloric restriction.
https://t.co/213PVJPZ6G

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@Ausbones https://t.co/ph3RBauVEq

[João Pedro de Magalhães @jpsenescence]

Ageing isn't one disease, it's a network.

Excited to share our latest study exploring the genetic links between ageing and age-related diseases 🧬

We show how shared pleiotropic genes connect disease clusters, revealing two distinct genetic architectures: one driven by ageing-related pathways and another by immune processes.

Using machine learning, we also predict new candidate ageing genes associated with intracellular signalling and programmed cell death.

Fantastic work by PhD student Gustavo Magdaleno 👏

https://t.co/v3z1aOffQe

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@biogerontology Cool! It may be worthwhile to collaborate with @cryodao and Oxford Cryo as they are also working on AI-guided cryopreservation methods.

[Anders Sandberg @anderssandberg]

This is what it looks like when a “future question” becomes a real one. Cryonics is already being discussed in terms of responsibility, law and institutions — not just technology.

[Nikola Danaylov Ⓥ @singularityblog]

"Being frozen is horrible. The alternative is worse." — David Ettinger, son of #cryonics founder Robert Ettinger.

I interviewed him 12 years ago on cryonics, vitrification & betting on life vs death. Still one of my best conversations.

🎙️ https://t.co/jPD1gCP3AB

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

@thecurioustales For more details on cryonics please see this @TEDx talk:
https://t.co/ph3RBauVEq

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

Here’s why some people choose cryonics to store their bodies and brains after death
https://t.co/4sK6WNOuRj

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

The Executive Who Sells Cryonics to the Ultra-Wealthy Chasing Immortality
https://t.co/VMhw3U5Pfh

[Cryonics and Cryopreservation Research Network @CryonicsNetwork]

This scientist rewarmed and studied pieces of his friend’s cryopreserved brain
https://t.co/2EVJQQ9n47

[Society for Technological Advancement @sotalikesfuture]

Letter to SoTA: Defeating Entropy Hackathon & SoTA Debate.

On 20th-22nd March, the Society for Technological Advancement (SoTA) and @LonLongevity are organising a debate on whole brain emulation and the Defeating Entropy Hackathon focused on radical life extension technologies.

The “Defeating Entropy” Hackathon (21–22nd March, London) will explore frontier approaches to defeating ageing, focusing on:
• Replacement — technologies to replace ageing cells, tissues, and organs (tissue engineering, neural replacement, biohybrid systems, advanced surgical tech).
• Biostasis / Cryobiology — technologies to slow or pause biological processes, with applications ranging from improved organ preservation to reproductive medicine to space exploration.

The SoTA Debate (20th March) will be centered on the motion:

“Can Whole Brain Emulation Deliver Radical Life Extension?”

Debaters:
@calarsenc (@netholabs )
@danburonline (@eightsixscience, @synconeticsorg)

Thank you to our partners who make this possible:
@pillar_vc , @angelversetti, Klona Biotech, @fiftyyears, @tomorrowbio

Read our letter (linked in the comments below) to learn more.

[João Pedro de Magalhães @jpsenescence]

“If nobody builds it, everyone dies”

Nick Bostrom’s latest piece on artificial superintelligence makes the point that, given we are all on course for dying in (by and large) the next few decades, developing a transformative technology like AGI is worth the risk.