CuezvaLab

The role of mitochondria in human pathology. At @CBMSO_CSIC_UAM @CIBERER.

[CuezvaLab @CuezvaLab]

In this study, we have investigated the alterations caused by ablation of IF1 in the colon. We demonstrated that ablation of IF1 promotes mitochondrial and Ca2+ dysfunction, activates futile ATP hydrolysis and promotes an adenosine-mediated inflammation. https://t.co/Gr4efmUyXG

[CuezvaLab @CuezvaLab]

Thanks to all the colleagues that participated in the project.

[Cristina Nuevo-Tapioles @CNuevoTapioles]

I’m very happy to share the last project I had the chance to participate in @CuezvaLab at @CBMSO_CSIC_UAM! "Analysis of the metabolic proteome of lung adenocarcinomas by RPPA emphasizes mitochondria as targets for therapy" https://t.co/bFEs0GsIxH (1/5)

[Cristina Nuevo-Tapioles @CNuevoTapioles]

We were very excited to see that this therapeutic approach provided better welfare to mice than cisplatin treatments, which, might result in an effective and less toxic therapeutic option for LUAD patients. Thank you @CuezvaLab and all the collaborators! @esparza_pau (5/5)

[Cristina Nuevo-Tapioles @CNuevoTapioles]

Indeed, treatment with a fatty acid assimilation or oxidation inhibitors in combination with the recently described OXPHOS inhibitor nebivolol (see https://t.co/pWVVP91QDn) significantly extended the lifespan of mice bearing lung adenocarcinomas (4/5)

[Cristina Nuevo-Tapioles @CNuevoTapioles]

steady-state levels of mitochondrial proteins of fatty acid oxidation, oxidative phosphorylation and of the antioxidant response are independent predictors of survival and/or of disease recurrence in LUAD patients. (3/5)

[Cristina Nuevo-Tapioles @CNuevoTapioles]

We used Reverse Phase Protein Arrays to quantify the changes in key metabolic enzymes in 128 tumors and paired non-tumor adjacent tissue of lung adenocarcinomas to profile the proteome of metabolism showing that (2/5)

[Cristina Nuevo-Tapioles @CNuevoTapioles]

I’m very happy to share the last project I had the chance to participate in @CuezvaLab at @CBMSO_CSIC_UAM! "Analysis of the metabolic proteome of lung adenocarcinomas by RPPA emphasizes mitochondria as targets for therapy" https://t.co/bFEs0GsIxH (1/5)

[CuezvaLab @CuezvaLab]

@CNuevoTapioles @hmg_journal Congratulations SuperYoli

[CuezvaLab @CuezvaLab]

@esparza_pau Congratulations Pau. It has been a big challenge that you have solved outstandingly. I have learned a lot with your imput. Thanks a lot

[genoxphos_lab @GenoxphosLab]

We are very proud to present the work: Na+ controls hypoxic signalling by the mitochondrial respiratory chain. And congratulations to Pablo Hernansanz-Agustín and all the colleges who collaborate with us. https://t.co/6Pbs2STHzl #mitochondria
#hypoxia #redox #SodiumMatters

[UAI_imas12 @UAI_imas12]

Investigadores del Instituto i+12 han demostrado que el bloqueo coordinado de la actividad mitocondrial y de la angiogénesis por el nebivolol frena el crecimiento de los tumores de mama y colon. NatureCommunications
https://t.co/aqtFZbwBfc @Itemas

[CuezvaLab @CuezvaLab]

Great idea @CNuevoTapioles

[Cristina Nuevo-Tapioles @CNuevoTapioles]

So happy to share a great part of my PhD work published in @NatureComms today. We propose to target mitochondrial metabolism and angiogenesis by inhibiting beta1-adrenergic cascade to arrest tumor growth. @CuezvaLab 1/6
https://t.co/pWVVP91iNP

[UCCUAM @UCCUAM]

📣 Un fármaco frena el crecimiento de los tumores de mama y colon

📌 Un estudio publicado en @NatureComms prueba que un fármaco anti-hipertensivo evita el crecimiento de este tipo de tumores, abriendo las puertas a una nueva terapia contra el #cáncer

▶️ https://t.co/Ps9aeiO31H

[PhD in Biomedical Sciences - UNIPD @PhD_DSB_UniPD]

A brand new @CellPressNews #paper from our former #PhDstudent Giulia Di Marco. In collaboration with @Novartis she identified new compounds that decrease #mitochondrial #calcium influx through #MICU1.
Read the full paper here⬇️

https://t.co/ESMKOcIPyo

[Cristina Nuevo-Tapioles @CNuevoTapioles]

Hoy @CuezvaLab estaremos en la sesión de resultados 4 en #RACIBERER2020 @CIBERER hablando sobre la estrategia del reposicionamiento de fármacos en la búsqueda de terapias para pacientes de Charcot-Marie-Tooth. #CMT #mitochondria