Patients with central sensitization not only had a much higher symptom burden, but also demonstrated reduced cerebral blood flow on standing and higher IL-6 levels, linking their symptoms to objective physiological abnormalities rather than subjective complaints alone. 2/
COVID-19 may occasionally leave behind more than fatigue and brain fog—it can trigger striking focal neurological syndromes.
➡️ Researchers describe a woman who developed painful tonic spasms—sudden, severe, involuntary posturing attacks—just two weeks after COVID-19. MRI revealed a solitary inflammatory lesion in the right cerebral peduncle, a key motor pathway in the brainstem. 1/
Scientists may have discovered a hidden network inside the human body that had gone unnoticed for decades.
In 2018, researchers described a widespread system of fluid filled spaces found throughout the body and suggested it could qualify as a newly recognized organ called the interstitium.
The structure is located beneath the skin, surrounding muscles, lining organs such as the lungs and digestive tract, and wrapping around blood vessels and the urinary system. For years, these layers were thought to be made mostly of dense connective tissue.
But when scientists examined living tissue using a laser imaging method known as probe based confocal laser endomicroscopy, they found something unexpected.
Instead of tightly packed solid tissue, they observed interconnected pockets filled with fluid and supported by a flexible network of collagen and connective fibers.
Researchers believe the structure had been missed for so long because of the way tissue samples are traditionally prepared for microscopes. Standard preparation methods involve chemically fixing tissue before examination, a process that drains the fluid and causes the spaces to collapse, making them appear solid.
In living tissue, however, the channels remain open and connected.
Scientists think the interstitium may help move fluid through the body and could influence inflammation, tissue aging, and even the spread of cancer.
Some researchers suspect these fluid pathways may help explain how certain cancers spread so quickly. Once cancer cells enter the network, the channels may allow them to travel into the lymphatic system and reach other parts of the body more easily.
The structure may also play a role in wrinkles and the stiffening of tissue that occurs with age.
Not all scientists agree that the interstitium should officially be classified as its own organ, and debate continues within the scientific community. Even so, the discovery has changed how many researchers think about human anatomy.
Read the study:
“Structure and Distribution of an Unrecognized Interstitium in Human Tissues.” Scientific Reports.
🚨MIT researchers have mathematically proven that ChatGPT’s built-in sycophancy creates a phenomenon they call “delusional spiraling.”
You ask it something, it agrees. You ask again, and it agrees even harder until you end up believing things that are flat-out false and you can’t tell it’s happening.
The model is literally trained on human feedback that rewards agreement.
Real-world fallout includes one man who spent 300 hours convinced he invented a world-changing math formula, and a UCSF psychiatrist who hospitalized 12 patients for chatbot-linked psychosis in a single year.
Source: @heynavtoor
Not all LongCOVID is the same.
➡️ Patients stratified using:
• GFAP
• Neurofilament light chain (NFL)
• IFN-β
➡️ Distinct biomarker-defined subgroups with different pathogenic pathways.
Proteome-wide profiling reveals:
➡️ Subgroup-specific autoantibody signatures
➡️ Persistent over time
➡️ Independently validated
Supports biological heterogeneity rather than a single syndrome. 2/
This high school student just built a water filter that removes 96% of microplastics, without expensive equipment.
In Warrington, Virginia, Mia Heller has built a filtration system that removes more than 95% of microplastics from drinking water. Her approach uses a magnetic liquid, ferrofluid, to pull tiny plastic particles out of the flow, without relying on traditional filter membranes.
🚨 Itchy Skin… But Nothing’s There?
What if the itch you feel isn’t coming from your skin at all?For many people with fibromyalgia, the scratching never seems to help. That’s because scientists believe the real cause may be hidden deep in the nervous system. The brain can send powerful itch signals—even when the skin looks completely normal.
It sounds strange… but your body might be creating sensations that aren’t really https://t.co/wxNPRdHaKP next time your skin feels like it’s crawling, ask yourself…Is it your skin—or your nerves playing tricks on you?
Source
Oaklander, A. L., Herzog, Z. D., Downs, H. M., & Klein, M. M. (2013). Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. *Pain*, 154(11),
Advanced brain imaging shows widespread white-matter neuroinflammation in ME/CFS, with tissue swelling, immune cell infiltration & nerve fiber reorganization across key brain pathways correlated with greater disability, even when standard MRIs look normal. https://t.co/6GKnohd3lN
Advanced brain imaging shows widespread white-matter neuroinflammation in ME/CFS, with tissue swelling, immune cell infiltration & nerve fiber reorganization across key brain pathways correlated with greater disability, even when standard MRIs look normal. https://t.co/6GKnohd3lN
Our potential future US surgeon general.
Her focus on healing is spot on. Bringing Americans and great institutions together is an important step towards progress.
@Neuroscope_mp@BrandonLuuMD Thats why it is better when a specialist Doctor who knows a lot about the ME/CFS dysautonomia gives tips. Only MD Specialist Doctors should give treatment advice and not anyone else https://t.co/WEvYuuq9K3
Important point: patients are not voluntarily hyperventilating or breathing abnormally. Patients have dysfunctional breathing and hyperventilation BECAUSE of cardiac preload failure and cerebral hypoperfusion.
#MECFS#POTS#LongCOVID#Dysautonomia
@JanetDafoe@DeryaTR_@BhupeshPrusty@ahandvanish
Can Metyrosine be explored in CFS patients in a "hyperadrenergic state"?
Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment
https://t.co/vpM9wFmnaf
BREAKING: Case Western just discovered the hidden protein interaction driving Parkinson's
They found alpha-synuclein attacks mitochondria (brain's power plants), cutting off energy. Then designed a drug that blocks this interaction
Restored movement in animal models ⚡
https://t.co/19i6kNacee
https://t.co/vOqmioTdjZ
My diagram with all the things I did in case it helps anyone else . I did self inject b12 and B1 every other day, but I’m not promoting this as self injecting carries risk . I also won’t be able to answer any questions about doing this as it’s not under nice guidelines 1/
"This research provides molecular validation for what ME/CFS patients have long known—that their bodies respond abnormally to exertion. The recovery phase in ME/CFS is characterized by prolonged, maladaptive molecular responses rather than a healthy return to baseline." #MECFS
A potential new direction for treating #LongCOVID and ME/CFS.
➡️ A NEW study suggests that IgG antibodies—and even their Fab fragments—from patients with ME/CFS, including those who developed the condition after COVID-19, can directly affect human endothelial cells.
➡️ The researchers found that these antibodies can alter mitochondrial structure and function, leading to mitochondrial fragmentation and changes in cellular energy metabolism. 1/