Cuylen Lab

[Yuki Hayashi @YH_YukiBio]

(1/8)

I’m excited to share that our work is now published in The EMBO Journal!

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties

A short summary is in the thread below, or you can jump straight to the paper here.

https://t.co/NRIwNVhvIV

[EMBL Events @EMBLEvents]

How can you tackle emerging questions in cellular organisation, adaptation, and robustness? Let's find out together! This is your reminder to register for the EMBO | EMBL Symposium 'Cellular mechanisms driven by phase separation'! 🧬🦠

The meeting will bring together scientists from cell biology, biophysics, biochemistry, molecular biology, structural biology, developmental biology, polymer physics, and soft matter physics to study condensates in biology and disease. #EESPhaseSeparation

Whether you are returning or new to the community, we hope you can join us next year!

📅 19 – 22 May 2026
📍 Heidelberg and Virtual
👉 Submit your abstract by 10 Feb 2026: https://t.co/fTLejjgTdf

[EMBL Events @EMBLEvents]

How to tackle emerging questions in cellular organisation, adaptation, and robustness? To find out, join the EMBO | EMBL Symposium 'Cellular mechanisms driven by phase separation'! 🧬🦠

The meeting will bring together scientists from cell biology, biophysics, biochemistry, molecular biology, structural biology, developmental biology, polymer physics, and soft matter physics to study condensates in biology and disease. #EESPhaseSeparation

Whether you are returning, or new to the community, we hope you can join us next year!

📅 19 – 22 May 2026
📍 Heidelberg and Virtual
👉 Submit your abstract by 10 Feb 2026: https://t.co/fTLejjgTdf

[PRX Life @PRX_Life]

RNA bridges between charged regions on chromosome surfaces drive long-range attraction and clustering, revealing a condensate-like mechanism tunable by charge patterns.

Read more: https://t.co/JXsx3cSyx5

[Cuylen Lab @CuylenLab]

🎉 Big congrats to @v_sorichetti and @SaricLab!
Their simulations reveal how Ki-67’s charge distribution drives chromosomes to cluster together.
Grateful to have contributed from @EMBL, with a special shout-out to our alumni PhD student @AHA_Alberto.
📖 https://t.co/Z8U5KBP0rP

[bioRxiv Cell Biology @biorxiv_cellbio]

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties https://t.co/XecO5AuRhm #biorxiv_cellbio

[Cuylen Lab @CuylenLab]

For more detail, check out this great thread from one of the first authors @YH_YukiBio explaining the findings:

[Yuki Hayashi @YH_YukiBio]

Excited to share our new preprint on @biorxivpreprint from our great team @EMBL!
https://t.co/JaeFubrQWd

If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells?
What controls the nucleolar shape?
#PhaseSeparation #Nucleolus

[Cuylen Lab @CuylenLab]

Ever wondered why nucleoli often have such complex shapes—despite behaving like liquids?
If liquids tend to form spheres, why don’t nucleoli?
What shapes them? We explore this in our latest preprint @embl.

Great work led by Daja Schichler & @YH_YukiBio!
https://t.co/Gtu72hUkOc

[Cuylen Lab @CuylenLab]

Interested in rapid imaging-based screening or sorting of rare cell populations? A new era of cell sorting has begun! Check out our latest review in @TrendCellBio on novel flow cytometers with imaging capabilities. Congrats, @terrabyte21!
https://t.co/51R7BEXGXm

[EMBL @embl]

EMBL Heidelberg researchers found how chromosomes switch from repelling each other to becoming sticky during cell division.

They saw that protein Ki-67 turn chromosomes’ surface into a liquid-like glue that helps in the formation of daughter nuclei.

🔛 https://t.co/IlwwRqHaRK

[Alberto Hernandez-Armendariz @AHA_Alberto]

Extremely happy to see our story out in @MolecularCell!
https://t.co/ntxVkcGizM

We show how Ki-67 & pre-rRNA phase separate, gluing mitotic #chromosomes together!
🧼🧬🧲

@EMBL @EMBLHeidelberg @UniHeidelberg @ISTAustria @CuylenLab @SaricLab @EllenbergLab

[Cuylen Lab @CuylenLab]

Our latest paper is out today @MolecularCell! Led by a @AHA_Alberto and with important contributions from @SaricLab & @EllenbergLab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here:
https://t.co/nXRWXkgJRc

[Cuylen Lab @CuylenLab]

@ralf_e_jansen @AHA_Alberto @embl @SaricLab @EllenbergLab Thanks! It has been shown that pre-RNAs are bound by Ki-67. We do not yet know whether other RNAs also bind to Ki-67.

[Cuylen Lab @CuylenLab]

Our new preprint describing how Ki-67 switches from a chromosome surfactant to a chromosome glue is online! Fantastic work lead by @AHA_Alberto @embl. Many thanks to our great collaborators from @SaricLab and @EllenbergLab.
https://t.co/7wFuowAfTJ

[Cuylen Lab @CuylenLab]

@manuelalonsoya1 @AHA_Alberto @embl @SaricLab @EllenbergLab Thank you, Manuel!

[Alberto Hernandez-Armendariz @AHA_Alberto]

I am extremely happy to share my @biorxivpreprint of my PhD work @EMBL! 🔬👨🏽‍🎓

A liquid-like coat mediates chromosome clustering during mitotic exit https://t.co/FjukpI7XBu

[EMBL @embl]

The EIPOD-LinC postdoctoral programme is open for applications!

Are you interested in self-designed interdisciplinary research on projects exploring life in context?

Then take a look at our fellowship programme:

https://t.co/HGUgfAGSJv

[Cuylen Lab @CuylenLab]

Excited to share our collaborative work with the Mahamid, Müller and @EllenbergLab! This has been a fantastic team effort @embl led by Herman Fung, @yukicosmos239 and @VeijoS.

[Nature Methods @naturemethods]

Exciting new work on genetically encoded multimeric tags for subcellular protein localization in cryo-EM from the Cuylen-Haering & Mahamid labs. https://t.co/3sDWPlYpkR

[EMBL @embl]

Image-enabled cell sorting (ICS) – a next-generation cell sorting method – is helping EMBL researchers gain new insights into cellular function in health and disease, as well as to explore other innovative applications.

https://t.co/8TaCEdFKfW

[Nature Methods @naturemethods]

Out today and freely available, a tool many in the image analysis community have been waiting for!

PyImageJ: A library for integrating ImageJ and Python

@EliceiriK @UWMadisonLOCI @ctrueden @CiminiLab @DrAnneCarpenter

https://t.co/2sjWSfJJ8n