If you’re passionate about aliphatic acid C–H functionalization, you absolutely must check out this paper! A truly exciting and insightful contribution showcasing elegant strategy, mechanistic depth, and powerful synthetic applications. Must see: https://t.co/LR8IaWtkZN
Enantioselective Nickel-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Alkenes toward Skipped Enones | Journal of the American Chemical Society https://t.co/IMzwrGOUsA
Enantioconvergent Decarboxylative Arylation of Serine and Isoserine Derivatives with Aryl Halides: Modular Access to Chiral 1,2-Amino Alcohols | Journal of the American Chemical Society https://t.co/HJATjEowsQ
Bioinspired Schenck-ene/Hock/Aldol Cascade Reaction Enables Concise Synthesis of Natural Products Alstoscholarinoid A, Masterpenoid D, Leontogenin, and Marsformoxide B https://t.co/5PnWvnMiRc
#chemistry#openaccess#science#chemtwitter
Researchers in Science report a kilogram-scale synthesis of enlicitide, a peptide drug for lowering low-density cholesterol that is in a Phase 3 clinical trial.
This new synthesis route leverages engineered enzymes and crystallization of key intermediates, substantially cutting down the number of reaction steps while improving yield. Learn more in a new #SciencePerspective: https://t.co/2g5nUA7d9G
Asymmetric Radical Allylic Cyanation of Electron-Deficient Alkenes with a Low Copper Catalyst Loading: Development and Mechanism | Journal of the American Chemical Society https://t.co/J7NSKqBdUM
Role of 2-Hydroxyimines in Chiral Phosphoric Acid-Catalyzed Mannich-Type Reactions: Enhancing Reactivity and Selectivity via Dimerization | Journal of the American Chemical Society https://t.co/34FFWNMqKO
Stereoreversed C–O Activation Unlocks All-Carbon Tetrasubstituted Z-Alkene Synthesis | Journal of the American Chemical Society https://t.co/RIaoI2Q5VA
In @NatureCatalysis we report the integration of photoredox radical generation and metal-carbenoid chemistry to achieve a formal metal carbenoid-radical coupling with enzymatic stereocontrol: https://t.co/WTy1CVxgXk