Mike Lin

🧬 Genome informatics R&D 🧬

[Crémieux @cremieuxrecueil]

Commencement speech, America: 'You can do anything, and you're going to do great!'

Commencement speech, Taiwan: 'Consider suicide if you make a mistake.'

[Hunter Biden @HunterBiden]

@iamno1s2hold He is a recovering crack addict that has now found a new addiction- it’s apparently called shit posting.

[Dominik Peters @DominikPeters]

I think people underestimate the effect GPT-5.x is already having on research in mathematical fields. 5.5 Pro has been proving many theorems for me, but I don’t talk about it much because I want to publish those results with my name on it and that’ll take time to write up.

[The Lincoln Project @ProjectLincoln]

Happy 1 year anniversary to this tweet.

[Jeremy Konyndyk @JeremyKonyndyk]

DOGE didn't make a dent in the deficit, but it did bring back screwworm and enable a historically large new Ebola outbreak, so it's not like they didn't achieve *anything*

[Jay in Kyiv @JayinKyiv]

All hell has broken loose at Putin's Economic Forum after Steven Seagal has reportedly eaten several members of the Chinese delegation.

Here, hurriedly waddling from the scene of the crime.

@sseagalofficial

[Hunter Biden @HunterBiden]

@mark_slapinski And I feel bad about that. I meant to say he is a sadistic, infantile ugly fuck.

[Hunter Biden @HunterBiden]

@Cactuscali19912 Stephen Miller is an ugly fuck.

[Alex Cole @acnewsitics]

Trump's health must be really bad for them to lie so obviously about it.

[Michael A. Cohen (NOT TRUMP’S FORMER FIXER) @speechboy71]

To sum up:

"After only three months, the war has cost the United States at least $29 billion in direct costs and the U.S. economy hundreds of billions in indirect costs.

It has killed and wounded U.S. servicemembers, damaged U.S. bases, depleted scarce munitions, raised energy prices, strained relations with partners, and left Washington scrambling to restore the status quo it disrupted. Even if there were tangible benefits to the war, the costs would more than outweigh them.

Even worse, the war could leave Iran’s nuclear capacity broadly unchanged, its missile force largely intact, its hard-liners empowered, its leverage over the Strait of Hormuz enhanced, and U.S. stockpiles depleted. This is worse than a failure. It is a strategic calamity."

[Noah Smith 🐇🇺🇸🇺🇦🇹🇼 @Noahpinion]

Trump started a war with Iran, lost the war, and is now sitting around pouting and hoping it'll just go away

[Boston Smalls @smalls2672]

Trump has lost in iran. They are fully in control. Global inventories are running out. Energy crisis about to hit that will make 2022 seem like a breeze. Asia, which is where roughly 40% of the world's manufacturing takes place is going to take the biggest hit first then Europe. We wont run out of gas or oil, whether you'llbe able to afford it is a different subject. Maga has literally made everyone's life in the entire world shittier other than the epstein pedo billionaire class they support. The world is being held hostage by the dumbest sacks of shit in our society. This is by far the worst strategic mistake of my lifetime and the repercussions will be felt for at least a generation. You cannot hate these ppl enough. Their stupidity has ruined us.

[The Shallow State @OurShallowState]

It almost looks to me as if Iran is mocking Trump. It looks to me as if Iran understands how to exploit his hyperbole. It looks to me as if Iran understands strategy and posture better than him. It looks to me as if Iran doesn't yet want to give him an exit.
Trump cannot stop bloviating- it's pathological. He needs to project grandiosity or he'll melt. He keeps mixing falsity with threats. He keeps saying Iran is diminished and has no cards.
Iran controls the Strait of Hormuz. That's a card.
Iran has enriched uranium. That's a card.
Iran took the US' best punch, and still fires missiles and drones. That's a card.
Iran still has its regime intact. That's a card.
Iran knows Trump is under political pressure before midterms and only cares about himself. That's a big card.
Iran knows Trump doesn't really speak for Netanyahu, who has used him as a patsy, so they can put it on Israeli attacks in Lebanon. That's a very big card.
Iran knows - Trump is a trapped moron. That's the biggest card of all.

[Itamar Golan 🤓 @ItakGol]

Men in their 40s used to have cool midlife crises… now they just have agentic workflows.

Bought a Claude subscription instead of a Porsche lmao.

[carl feynman @carl_feynman]

TLDR: a nice paper for the excessively mathematical ML engineer.

I used to worry about search getting caught in local minima, before 2015 or so. Since then, it has been pounded into me by experience that local minima are rare: in high dimensions, almost all critical points are saddles. So I believe it, but didn't feel like I had a good theoretical justification. I noodled around with the math, but didn't come up with a good model. This paper satisfied my theoretical unease. It shows that the probability of a random critical point being a local minimum goes as exp(-N^2), for dimension N, under a plausible random field model. I don't think it's original; I just didn't know about it because I don't keep up with the literature. But it is short, clearly written, and nicely explained.

[Angry Staffer @Angry_Staffer]

FYI this is the test Trump is bragging about “acing” 4 times

It’s a fucking embarrassment that his handlers are still letting him gloat about this like it’s some extreme act of intellect

[Adam Kinzinger (Slava Ukraini) 🇺🇸🇺🇦 @AdamKinzinger]

The US lost in Iran not because of the military.

Because of terrible leadership and lack of will

[kache @yacineMTB]

There is an autism lottery. Either you're autistic about something totally monetarily useless like sonic speedrunning, or you are autistic about something that makes a fuck ton of money like GPU schedulers

[Andrea Junker @Strandjunker]

No snark, I genuinely don’t get it. Trump is one of the least masculine, most juvenile public figures out there. He’s needy, whiny, defensive, terrified of strong women, and visibly intimidated by powerful men.

How does his base spin this into the ultimate “strongman” image?

[scary lawyerguy @scarylawyerguy]

All Trump wants is a piece of paper he can wave in the air and call it a "deal" so he can focus on the important matters of state like the UFC fight he's hosting at the White House in two weeks. He doesn't give a shit about the details or the damage he's done.