David Shechter

Epigenetically engineering a kosher pig

or

how I stopped worrying and learned to love charge, grease, and intrinsic disorder

Opinions are my own

[David Shechter @DShechter]

Why can’t cells live without PRMT5? Our new transformative work inspired and led by @JacobRoth13 shows that this arginine methyltransferase is critical for histone production and genome stability.

Full story: https://t.co/KzdnInZcEV
1/5

[Joe Walsh @WalshFreedom]

I don’t care that Platner is a sex addict who’s cheated on his wife. I care that he’s an antisemite who knowingly had a Nazi tattoo for 18yrs, and when caught, he lied about it. I care that his entire “working class” persona is a lie. And that’s just a start. He’s a really bad, dishonest guy. If I lived in Maine, I wouldn’t vote for him or Susan Collins.

[David Shechter @DShechter]

6/ The work also points to GNMT S9ph as a feedback tuning mechanism. Because this modification is enriched in aged mouse liver, these findings may have implications for age-associated changes in one-carbon metabolism and methylation homeostasis. https://t.co/cfgICKt3cy

[David Shechter @DShechter]

1/ New preprint from the lab, led by MSTP student @isaackraz: https://t.co/cfgICKt3cy
SAM (S-adenosylmethionine) is the universal methyl donor used for DNA, RNA, protein, and metabolite methylation. Maintaining SAM homeostasis is essential - but how is it regulated?

[David Shechter @DShechter]

5/ Overall, these findings position the GNMT N-terminus as a key regulatory element linking folate status to cellular methylation potential

[Juliet Moses @JulietMosesNZ]

During the Spanish Inquisition, Jews could ostensibly redeem themselves by converting to Christianity and conforming to the prevailing orthodoxy.
During this one, Jews can ostensibly redeem themselves by renouncing Israel’s existence and conforming to the prevailing orthodoxy.
No serious person looking back at the Spanish Inquisition would argue that Jews were not persecuted, just because they had the chance to opt-out by excising a fundamental part of their identity.
And no serious person should argue it now.

[Alex גדעון בן װעלװל @JewishWonk]

This is a thread on the state of American Jewry in light of unabetted growth in American antisemitism on the right and left. What's going right, what's going wrong, and some options in front of us.

[Jeffrey Goldberg @JeffreyGoldberg]

"What’s most incredible is not that Platner would attempt to spin something that is obviously disqualifying. It’s that the leaders of his party are accepting that spin." -- @mikenelson586:
https://t.co/bmqXgCvFAm

[Joe Walsh @WalshFreedom]

Well done, MAGA. Well done, Trump followers. Well done, all my former Republican congressional colleagues. Well done, all my former right wing media colleagues. Your cowardice, your fear, your caring only about ratings/audience/votes/getting elected/staying in power, your placing party over country, your abandonment of all principle, your cultish devotion to a corrupt, lawless sociopath brought us here. Well done. Hope you’re proud.👇

[Joe Walsh @WalshFreedom]

Trump is looting the country on an unprecedented scale and the lesson/reason is because we don’t have a legislative branch. The past 16 months is what America looks like without a Congress.

[Derek Thompson @DKThomp]

Within one 24 hour period, Trump:

- got out of a $100 million IRS fine
- secured "immunity" from all future tax investigations for his family and friends
- created a $1.8 billion slush fund for lawbreaking supporters
- was reported for likely insider trading worth nearly $1 billion

All of the obvious things to say about this are true. It's bad. Nobody even tries to defend it. The closest thing to a defense you get is something about how "but Democrats suck" and "woke was also bad," which is not a defense, but rather a kind of moral blank check made out to the administration to give them the right to do anything.

But what I'm most curious about is whether this sort of lurid corruption creates a countermovement that successfully returns government to rule of law or whether it's establishing a norm of executive imperialism that every future administration will use to achieve its ends, which can always be justified by the moral blank check of "the other side is worse, so let us do whatever we want."

[The Lincoln Project @ProjectLincoln]

Absolutely insane levels of corruption happening right before your eyes.

[Sonny Bunch @SonnyBunch]

I'm sorry, this $1.8 billion Trump slush fund designed to reward people who broke the law on Trump's behalf that will be administered entirely by Trump is COMPLETELY AND UTTERLY INSANE. There's really no other way to describe it. https://t.co/FbjzxHRkK9

[Jeremiah Johnson 🌐 @JeremiahDJohns]

Trump looting almost $2 billion from the government coffers to pay his supporters is one of the largest scandals in US history.

But our press is so beaten down and the public has become so fatigued by his constant criminality that it's barely a news story.

[Barbara Comstock @BarbaraComstock]

👀The top lawyer at the Treasury Dept stepped down on Monday in the wake of the creation of a $1.8 billion “anti-weaponization fund” that could soon make payments to President Trump’s political allies, according to 3 people familiar with the move.
Brian Morrissey, the Treasury’s general counsel, resigned from the position 7 months after he was confirmed to it by the Senate and just hours after the Trump administration announced the fund on Monday.
Mr. Morrissey did not respond to requests for comment.

[Marco Foster @MarcoFoster_]

Don Lemon: “If Barack Obama had sued his own government, settled with himself in secret, created a billion dollar fund with no congressional oversight to pay his political allies. What if he did that? They would’ve had him in chains before sundown. The National Guard would have been called in. Impeachment articles would have been filed. Can you imagine Fox News?”

[Omri @OVisionIL]

Israel has more Muslim citizens than the number of Jews in the ENTIRE CONTINENT OF EUROPE

[Eylon Levy @EylonALevy]

Pretty sick of the countries that are boycotting Eurovision because the Jews are competing. Before you say “don’t conflate!”, these are countries that expelled their Jews (Spain), or refused to welcome Holocaust refugees (Ireland), or where most Jews were genocided (Netherlands). Europe liquidated its Jewish population in living memory and the survivors built new lives in Israel. Now these entitled, hateful broadcasters are boycotting the show in solidarity with the territorist armies that tried to kill those survivors. It’s so fucked up.